Entity Details

Primary name CDKN2A
Entity type gene
Source Source Link

Details

PrimaryID1029
RefseqGeneNG_007485
SymbolCDKN2A
Namecyclin dependent kinase inhibitor 2A
Chromosome9
Location9p21.3
TaxID9606
Statuslive
SourceGenomegenomic
SourceOriginnatural
CreationDate1998-08-05
ModificationDate2021-06-20

Ontological Relatives

GO terms

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GOName
GO:0000082 G1/S transition of mitotic cell cycle
GO:0000209 protein polyubiquitination
GO:0000422 autophagy of mitochondrion
GO:0001953 negative regulation of cell-matrix adhesion
GO:0002039 p53 binding
GO:0003677 DNA binding
GO:0003723 RNA binding
GO:0004861 cyclin-dependent protein serine/threonine kinase inhibitor activity
GO:0005634 nucleus
GO:0005654 nucleoplasm
GO:0005730 nucleolus
GO:0005737 cytoplasm
GO:0005739 mitochondrion
GO:0005759 mitochondrial matrix
GO:0005829 cytosol
GO:0006364 rRNA processing
GO:0006469 negative regulation of protein kinase activity
GO:0006919 activation of cysteine-type endopeptidase activity involved in apoptotic process
GO:0007265 Ras protein signal transduction
GO:0008134 transcription factor binding
GO:0008285 negative regulation of cell population proliferation
GO:0008637 apoptotic mitochondrial changes
GO:0010389 regulation of G2/M transition of mitotic cell cycle
GO:0010628 positive regulation of gene expression
GO:0019789 SUMO transferase activity
GO:0019901 protein kinase binding
GO:0030308 negative regulation of cell growth
GO:0030889 negative regulation of B cell proliferation
GO:0031647 regulation of protein stability
GO:0031648 protein destabilization
GO:0032088 negative regulation of NF-kappaB transcription factor activity
GO:0032991 protein-containing complex
GO:0033088 negative regulation of immature T cell proliferation in thymus
GO:0033235 positive regulation of protein sumoylation
GO:0034393 positive regulation of smooth muscle cell apoptotic process
GO:0035985 senescence-associated heterochromatin focus
GO:0035986 senescence-associated heterochromatin focus assembly
GO:0042326 negative regulation of phosphorylation
GO:0043065 positive regulation of apoptotic process
GO:0043517 positive regulation of DNA damage response, signal transduction by p53 class mediator
GO:0045736 negative regulation of cyclin-dependent protein serine/threonine kinase activity
GO:0045892 negative regulation of transcription, DNA-templated
GO:0045893 positive regulation of transcription, DNA-templated
GO:0045944 positive regulation of transcription by RNA polymerase II
GO:0046825 regulation of protein export from nucleus
GO:0048103 somatic stem cell division
GO:0050821 protein stabilization
GO:0051059 NF-kappaB binding
GO:0051444 negative regulation of ubiquitin-protein transferase activity
GO:0051882 mitochondrial depolarization
GO:0055105 ubiquitin-protein transferase inhibitor activity
GO:0060260 regulation of transcription initiation from RNA polymerase II promoter
GO:0070534 protein K63-linked ubiquitination
GO:0090398 cellular senescence
GO:0090399 replicative senescence
GO:0097193 intrinsic apoptotic signaling pathway
GO:0097371 MDM2/MDM4 family protein binding
GO:0097718 disordered domain specific binding
GO:1900182 positive regulation of protein localization to nucleus
GO:1901796 regulation of signal transduction by p53 class mediator
GO:1901798 positive regulation of signal transduction by p53 class mediator
GO:1902510 regulation of apoptotic DNA fragmentation
GO:1903051 negative regulation of proteolysis involved in cellular protein catabolic process
GO:1903214 regulation of protein targeting to mitochondrion
GO:1904667 negative regulation of ubiquitin protein ligase activity
GO:1990000 amyloid fibril formation
GO:1990948 ubiquitin ligase inhibitor activity
GO:2000059 negative regulation of ubiquitin-dependent protein catabolic process
GO:2000111 positive regulation of macrophage apoptotic process
GO:2000134 negative regulation of G1/S transition of mitotic cell cycle
GO:2000435 negative regulation of protein neddylation
GO:2000774 positive regulation of cellular senescence

Diseases

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Interactions

296 interactions

InteractorPartnerSourcesPublicationsLink
CDKN2ACDK6BioGRID, HPRD, IntAct10022865 10491434 11556834 11739795 15232106 17881001 17909018 17955473 23602568 24855949 26186194 28205554 28514442 8805225 9380698 9751050 details
CDKN2ACDK4BioGRID, DIP, HPRD, IntAct, MINT10022865 10491434 10580009 10585280 10719365 11556834 11900540 12529334 15065884 15232106 17353931 17517622 17881001 17909018 17955473 23455922 23602568 24855949 24981860 26186194 26496610 28042499 28205554 28218424 28514442 8259215 8805225 9228064 9529249 details
CDKN2AGMNNBioGRID, HPRD, IntAct15232106 27229929 details
CDKN2AORC4BioGRID, HPRD, IntAct15232106 details
CDKN2ACDC6BioGRID, HPRD, IntAct15232106 details
CDKN2AORC5IntAct15232106 details
CDKN2ACDC45BioGRID, HPRD, IntAct15232106 details
CDKN2ACDC7BioGRID, HPRD, IntAct15232106 details
CDKN2AMCM2BioGRID, HPRD, IntAct15232106 details
CDKN2AMCM10BioGRID, HPRD, IntAct15232106 details
CDKN2AMCM5BioGRID, HPRD, IntAct15232106 details
CDKN2ASLC4A1BioGRID, HPRD, MINT15811326 details
CDKN2AHUWE1BioGRID, HPRD, IntAct, UniProt15989956 22561347 26212014 26496610 28193319 details
CDKN2ANPM1BioGRID, DIP, MINT, UniProt14636574 15989956 16679321 16957780 18259216 20308430 22561347 23851489 24769896 25600590 29283500 details
CDKN2AVHLBioGRID, IntAct17353931 21942715 26211615 7604013 details
CDKN2AMDM2BioGRID, HPRD, IntAct, MINT, UniProt10801444 10822382 10871849 11223036 12085228 12167711 12630860 12740913 14612427 15355988 16107876 16173922 16702947 17116689 17426254 17909018 18418067 18467333 18541670 18583933 18813780 19049976 19166854 20395212 20713054 21133853 22120712 22467867 24769896 25809483 28205554 29057323 9529248 9529249 9653180 9724636 details
CDKN2ATP53BioGRID, IntAct, MINT12446718 12740913 14612427 20395212 22348305 22467867 22653443 28205554 28218424 9529249 9653180 9724636 details
CDKN2APPP1CCBioGRID, IntAct17274640 details
CDKN2APPP1CBBioGRID, IntAct17274640 details
CDKN2APCNABioGRID, IntAct17955473 details
CDKN2AMCM6BioGRID, IntAct17955473 details
CDKN2ASNRPABioGRID, IntAct17955473 details
CDKN2ATUBA1CBioGRID, IntAct17955473 details
CDKN2AUSP26BioGRID, IntAct17955473 details
CDKN2AHSPA9BioGRID, IntAct17955473 19049976 details
CDKN2ASNRPBBioGRID, IntAct17955473 details
CDKN2ATUBA1ABioGRID, IntAct17955473 details
CDKN2ATUBB4BBioGRID, IntAct17955473 details
CDKN2ATUBBBioGRID, IntAct17955473 details
CDKN2AUBE4BBioGRID, IntAct17955473 details
CDKN2AMYL12ABioGRID, IntAct17955473 details
CDKN2AHNRNPA2B1BioGRID, IntAct17955473 details
CDKN2AMMRN1BioGRID, IntAct17955473 details
CDKN2ARUVBL2BioGRID, IntAct17955473 details
CDKN2AHSPA4BioGRID, IntAct17955473 details
CDKN2APDCD6BioGRID, IntAct17955473 details
CDKN2AEPHA3BioGRID, IntAct17955473 details
CDKN2AEEF2BioGRID, IntAct17955473 details
CDKN2AMTRBioGRID, IntAct17955473 details
CDKN2AACTBBioGRID, IntAct17955473 details
CDKN2AHSPA8BioGRID, IntAct17955473 details
CDKN2AACLYBioGRID, IntAct17955473 details
CDKN2ARIN2BioGRID, IntAct17955473 details
CDKN2AACTN4BioGRID, IntAct17955473 details
CDKN2AHSP90AA1BioGRID, IntAct17955473 details
CDKN2AHNRNPCBioGRID, IntAct17955473 details
CDKN2AHSP90AB1BioGRID, HPRD, IntAct16582619 17955473 details
CDKN2AACTG1BioGRID, IntAct17955473 22863883 details
CDKN2AGAPDHBioGRID, IntAct17955473 details
CDKN2ADAXXBioGRID, UniProt18583933 details
CDKN2AEGR1BioGRID, HPRD, MINT19057511 details
CDKN2AZNF420BioGRID, MINT20713054 25691462 details
CDKN2APRKCABioGRID, IntAct21988832 details
CDKN2AFN1BioGRID, IntAct21988832 details
CDKN2AHNRNPUBioGRID, IntAct21988832 details
CDKN2ADEAF1BioGRID, IntAct21988832 details
CDKN2ATDRD7BioGRID, IntAct21988832 details
CDKN2ACRELD2BioGRID, IntAct21988832 details
CDKN2ABAATBioGRID, MINT24412244 details
CDKN2AALDOBBioGRID, MINT24412244 details
CDKN2AAOPEPBioGRID, MINT24412244 details
CDKN2ACDC14BBioGRID, MINT24412244 details
CDKN2ACTSVBioGRID, MINT24412244 details
CDKN2ACYLC2BioGRID, MINT24412244 details
CDKN2AFRAT2BioGRID, MINT24412244 details
CDKN2AHRASBioGRID, MINT24412244 details
CDKN2AGALNT12BioGRID, MINT24412244 details
CDKN2AMAP2K1BioGRID, MINT24412244 details
CDKN2ACCDC180BioGRID, MINT24412244 details
CDKN2AMAPKAPK3MINT24412244 details
CDKN2ARASA1BioGRID, MINT24412244 details
CDKN2ASEC61BBioGRID, MINT24412244 details
CDKN2ATGFB1BioGRID, MINT24412244 details
CDKN2ASFRP4BioGRID, MINT24412244 details
CDKN2ATMOD1BioGRID, MINT24412244 details
CDKN2AMSANTD3-TMEFF1MINT24412244 details
CDKN2ATMEFF1BioGRID, MINT24412244 details
CDKN2AANGPTL4BioGRID, MINT25640309 details
CDKN2ACASC3BioGRID, MINT25640309 details
CDKN2ANAT2BioGRID, MINT25640309 details
CDKN2ANSD3BioGRID, MINT25640309 details
CDKN2ACCND1BioGRID, IntAct10580009 17420273 24855949 26496610 28042499 details
CDKN2ATRIP12BioGRID, DIP20208519 22561347 23034180 24769896 27323397 details
CDKN2ASP1BioGRID, DIP21555589 details
CDKN2APPP1R9BBioGRID, HPRD11278317 details
CDKN2ACCND2BioGRID11900540 15065884 28205554 details
CDKN2ASERTAD1BioGRID, HPRD10580009 15065884 details
CDKN2ARPL11BioGRID14612427 22467867 details
CDKN2AE4F1BioGRID, HPRD12446718 details
CDKN2ACCNG1BioGRID, HPRD12556559 details
CDKN2AMDM4BioGRID11297540 28205554 details
CDKN2APSMC3BioGRID, HPRD14665636 17334400 details
CDKN2ASMARCA4BioGRID19149898 details
CDKN2AKAT5BioGRID16705183 details
CDKN2AYY1BioGRID15210108 details
CDKN2AH2BU1BioGRID21846774 details
CDKN2AHDAC1BioGRID21846774 details
CDKN2AARFIP2BioGRID11792819 details
CDKN2AGGA1BioGRID11792819 details
CDKN2AWRNBioGRID, HPRD15355988 details
CDKN2ATP63BioGRID15367673 details
CDKN2ANCLBioGRID, HPRD14636574 16582619 details
CDKN2ACOMMD1BioGRID18305112 details
CDKN2ACDK5RAP3BioGRID16173922 23028987 28027003 details
CDKN2ACTBP2BioGRID16508011 details
CDKN2AMYCBioGRID, HPRD15361884 16410719 17289033 20308430 23277542 28205554 details
CDKN2AGGA3BioGRID21517092 details
CDKN2ACDKN2AIPBioGRID, HPRD12154087 12581788 17460193 details
CDKN2ANMIBioGRID23034180 details
CDKN2AHIF1ABioGRID, HPRD11382768 28205554 details
CDKN2AE2F1BioGRID, HPRD11314038 16135794 20106982 details
CDKN2ASIVA1BioGRID23462994 details
CDKN2ACDC5LBioGRID, HPRD15232106 details
CDKN2AMAPK8BioGRID16007099 details
CDKN2AMAPK10BioGRID16007099 details
CDKN2AGNL3BioGRID24769896 details
CDKN2ABCL2L1BioGRID19049976 details
CDKN2ABECN1BioGRID19049976 28205554 details
CDKN2AZBTB17BioGRID19901969 details
CDKN2ATRIM28BioGRID26055329 details
CDKN2ANOP53BioGRID27323397 details
CDKN2AUBCBioGRID28190767 details
CDKN2AANKRA2BioGRID27229929 details
CDKN2AASPRV1BioGRID27229929 details
CDKN2AAZIN1BioGRID27229929 details
CDKN2AANAPC15BioGRID27229929 details
CDKN2AZGRF1BioGRID27229929 details
CDKN2ACCNDBP1BioGRID27229929 details
CDKN2ACENPABioGRID27229929 details
CDKN2AEFHC2BioGRID27229929 details
CDKN2AEXOC2BioGRID27229929 details
CDKN2AHLA-DOBBioGRID27229929 details
CDKN2AMAF1BioGRID27229929 details
CDKN2APTP4A3BioGRID27229929 details
CDKN2ARBM26BioGRID27229929 details
CDKN2ASIX2BioGRID27229929 details
CDKN2AUBL7BioGRID27229929 details
CDKN2AVAMP1BioGRID27229929 details
CDKN2AZNF687BioGRID27229929 details
CDKN2AZUP1BioGRID27229929 details
CDKN2ACDKN2ABioGRID, HPRD28205554 29283500 8755727 8910511 details
CDKN2AISOC2BioGRID17658461 details
CDKN2AERBB3BioGRID22261253 details
CDKN2ATFDP1BioGRID16135794 details
CDKN2AARNTBioGRID28205554 details
CDKN2ACCNE1BioGRID28205554 details
CDKN2AEPHA2BioGRID28205554 details
CDKN2ASTK11BioGRID28205554 details
CDKN2ACDKN2BBioGRID24981860 28205554 details
CDKN2AFZR1BioGRID28205554 details
CDKN2AMAP2K5BioGRID28205554 details
CDKN2ARASSF1BioGRID28205554 details
CDKN2ASOX4BioGRID28205554 details
CDKN2AAKT1BioGRID28205554 details
CDKN2ACD44BioGRID28205554 details
CDKN2AFGFR4BioGRID28205554 details
CDKN2ALATS2BioGRID28205554 details
CDKN2AMAP3K5BioGRID28205554 details
CDKN2ATEAD2BioGRID28205554 details
CDKN2ATERTBioGRID28205554 details
CDKN2ATSC1BioGRID28205554 details
CDKN2AGLIS1BioGRID28205554 details
CDKN2AGLIS2BioGRID28205554 details
CDKN2AHGFBioGRID28205554 details
CDKN2AMAPK14BioGRID28205554 details
CDKN2APDGFRABioGRID28205554 details
CDKN2ARAF1BioGRID28205554 details
CDKN2ASOX3BioGRID28205554 details
CDKN2AMAPK3BioGRID24412244 details
CDKN2ACDC42BioGRID31478661 details
CDKN2ARPS7HPRD16582619 details
CDKN2ATBRG1HPRD16582619 details
CDKN2ACCDC183HPRD16582619 details
CDKN2AANKRD12HPRD16582619 details
CDKN2AZNF227HPRD16582619 details
CDKN2APEX19HPRD16582619 details
CDKN2AZFP91HPRD16582619 details
CDKN2ATPI1HPRD16582619 details
CDKN2AAHNAKHPRD16582619 details
CDKN2ACARFHPRD12154087 details
CDKN2AZNF410HPRD12370286 details
CDKN2AATG5IntAct17353931 details
CDKN2AFTSJ1IntAct17353931 details
CDKN2AEIF1BIntAct17353931 details
CDKN2AMCCIntAct17353931 details
CDKN2AACTR3BIntAct17353931 details
CDKN2AHLA-BIntAct17353931 details
CDKN2AIKBKEIntAct17353931 details
CDKN2AEPB41IntAct17353931 details
CDKN2APMLBioGRID, IntAct12740913 26578773 details
CDKN2AMYCNBioGRID, MINT17289033 details
CDKN2ASUMO2MINT18259216 details
CDKN2AC1QBPBioGRID, UniProt17486078 19049976 details
CDKN2ARANIntAct24855949 details
CDKN2AMTA1DIP21555589 details
CDKN2AUBE2ABioGRID, HPRD12640129 details
CDKN2AFKBP2BioGRID12606707 details
CDKN2AING4BioGRID18775696 details
CDKN2ATOP1BioGRID12673200 15361825 18004878 details
CDKN2APSME3BioGRID17588519 31565481 details
CDKN2AING1BioGRID19085961 details
CDKN2AUCHL1BioGRID20395212 details
CDKN2ATTF1BioGRID22383580 details
CDKN2ATRADDBioGRID22561347 details
CDKN2AUBE2IBioGRID15876874 25691462 26578773 details
CDKN2ASENP3BioGRID18948745 details
CDKN2ARNF2BioGRID22910419 details
CDKN2APIAS2BioGRID20308430 details
CDKN2ABRCA1BioGRID18703154 details
CDKN2AIKBKBBioGRID20152798 details
CDKN2AATRBioGRID15775976 details
CDKN2ARELABioGRID25331947 details
CDKN2APA2G4BioGRID19946338 details
CDKN2AKAT2BBioGRID28042499 details
CDKN2AARBioGRID23449888 details
CDKN2ACDKN1CBioGRID20106982 details
CDKN2ABACH1BioGRID22348305 details
CDKN2ACOPS6BioGRID31565481 details
CDKN2ACDKN2CBioGRID, HPRD24981860 8259215 details
CDKN2AAURKABioGRID, IntAct17353931 details
CDKN2AHIPK4BioGRID, IntAct23602568 details
CDKN2ACDK11ABioGRID, IntAct23602568 details
CDKN2ADYRK1BBioGRID, IntAct23602568 details
CDKN2ACOPS5BioGRID, IntAct21145461 details
CDKN2ACUL2BioGRID, IntAct21145461 details
CDKN2AMAPK6BioGRID, IntAct26972000 details
CDKN2AOTUB1IntAct26752685 details
CDKN2AMIS12BioGRID, IntAct26496610 details
CDKN2AMYO1CBioGRID, IntAct26496610 details
CDKN2ACFAP97BioGRID, IntAct26496610 details
CDKN2AIQGAP1BioGRID, IntAct26496610 details
CDKN2ABAG6BioGRID, IntAct26496610 details
CDKN2AKSR1IntAct27086506 details
CDKN2AKSR2IntAct27086506 details
CDKN2ARRP1BIntAct20926688 details
CDKN2AAURKBBioGRID, IntAct29568061 31586073 details
CDKN2AFBLBioGRID, IntAct29568061 details
CDKN2ALMNABioGRID, IntAct29568061 details
CDKN2ARAB5ABioGRID, IntAct29568061 details
CDKN2ATUBG1BioGRID, IntAct29568061 details
CDKN2ACANXBioGRID, IntAct29568061 details
CDKN2AMETTL3BioGRID, UniProt29507755 details
CDKN2AMETTL14BioGRID, UniProt29507755 details
CDKN2APSEN1BioGRID, UniProt25959826 details
CDKN2AARHGAP25BioGRID, IntAct32203420 details
CDKN2AARHGEF6BioGRID, IntAct32203420 details
CDKN2AZDHHC5UniProt31402609 details
CDKN2AKATNIPUniProt26714646 details
CDKN2ASAP25BioGRID16449650 details
CDKN2ACLK2BioGRID23602568 details
CDKN2ABRK1BioGRID22863883 details
CDKN2AACTA1BioGRID22863883 details
CDKN2AACTBL2BioGRID22863883 details
CDKN2ACSTF2BioGRID22863883 details
CDKN2ALSM8BioGRID22863883 details
CDKN2ANCKAP1BioGRID22863883 details
CDKN2ARPP38BioGRID22863883 details
CDKN2ADGCR8BioGRID24778252 details
CDKN2AEGLN3BioGRID26972000 details
CDKN2AZBTB38BioGRID29490077 details
CDKN2AVCPBioGRID29540532 details
CDKN2ARC3H1BioGRID30209976 details
CDKN2ATPT1BioGRID28846114 details
CDKN2ANR2C2BioGRID30463901 details
CDKN2ACLUAP1BioGRID29615496 details
CDKN2ABIRC3BioGRID30948266 details
CDKN2ALMBR1LBioGRID31073040 details
CDKN2AEP300BioGRID30110629 details
CDKN2ALRRK2BioGRID31046837 details
CDKN2APLEKHA4BioGRID31091453 details
CDKN2AZC3H18BioGRID29298432 details
CDKN2ACITBioGRID31586073 details
CDKN2AECT2BioGRID31586073 details
CDKN2AKIF14BioGRID31586073 details
CDKN2APRC1BioGRID31586073 details
CDKN2ABRPF3BioGRID31753913 details
CDKN2ATAF1BioGRID31753913 details
CDKN2AMAFBBioGRID31822558 details
CDKN2AYWHAEBioGRID23472066 details
CDKN2ARIN3BioGRID32552912 details
CDKN2AAK2BioGRID24981860 details
CDKN2ACDKN2DBioGRID24981860 details
CDKN2ACDC37BioGRID24981860 details
CDKN2AMAPK1BioGRID24981860 details
CDKN2AERGIC1BioGRID34079125 details
CDKN2APANX1BioGRID34079125 details
CDKN2APEX3BioGRID34079125 details
CDKN2ATLE1IntAct22439931 details
CDKN2AATF2IntAct22439931 details
CDKN2AEZH2IntAct23238014 details
CDKN2ACUL4BIntAct23238014 details
CDKN2ADDB1IntAct23238014 details
CDKN2ASUZ12IntAct23238014 details
CDKN2AMOV10BioGRID22658674 details
CDKN2ANXF1BioGRID22658674 details
CDKN2AHNRNPH1BioGRID26760575 details