Entity Details

Primary name M3K12_HUMAN
Entity type UniProt
Source Source Link

Details

AccessionQ12852
EntryNameM3K12_HUMAN
FullNameMitogen-activated protein kinase kinase kinase 12
TaxID9606
Evidenceevidence at protein level
Length859
SequenceStatuscomplete
DateCreated2001-09-26
DateModified2021-06-02

Ontological Relatives

GenesMAP3K12

GO terms

Show/Hide Table
GOName
GO:0004672 protein kinase activity
GO:0004674 protein serine/threonine kinase activity
GO:0004706 JUN kinase kinase kinase activity
GO:0005524 ATP binding
GO:0005737 cytoplasm
GO:0005829 cytosol
GO:0005886 plasma membrane
GO:0006468 protein phosphorylation
GO:0007254 JNK cascade
GO:0007256 obsolete activation of JNKK activity
GO:0007257 obsolete activation of JUN kinase activity
GO:0016020 membrane
GO:0016572 histone phosphorylation
GO:0018105 peptidyl-serine phosphorylation
GO:0018107 peptidyl-threonine phosphorylation
GO:0019901 protein kinase binding
GO:0030426 growth cone
GO:0035556 intracellular signal transduction
GO:0042803 protein homodimerization activity
GO:0045893 positive regulation of transcription, DNA-templated
GO:0046777 protein autophosphorylation
GO:0070374 positive regulation of ERK1 and ERK2 cascade
GO:0106310 protein serine kinase activity
GO:0106311 protein threonine kinase activity
GO:2000672 negative regulation of motor neuron apoptotic process

Subcellular Location

Show/Hide Table
Subcellular Location
Cell membrane
Cytoplasm

Domains

Show/Hide Table
DomainNameCategoryType
IPR000719 Protein kinase domainDomainDomain
IPR001245 Serine-threonine/tyrosine-protein kinase, catalytic domainDomainDomain
IPR008271 Serine/threonine-protein kinase, active siteSiteActive site
IPR011009 Protein kinase-like domain superfamilyFamilyHomologous superfamily
IPR017419 Mitogen-activated protein kinase kinase kinase 12/13FamilyFamily
IPR027257 Mitogen-activated protein kinase kinase kinase 12FamilyFamily

Diseases

Show/Hide Table

Drugs

Show/Hide Table
DrugNameSourceType
DB12010 FostamatinibDrugbanksmall molecule