Entity Details

Primary name M3K1_HUMAN
Entity type UniProt
Source Source Link

Details

AccessionQ13233
EntryNameM3K1_HUMAN
FullNameMitogen-activated protein kinase kinase kinase 1
TaxID9606
Evidenceevidence at protein level
Length1512
SequenceStatuscomplete
DateCreated1997-11-01
DateModified2021-06-02

Ontological Relatives

GenesMAP3K1

GO terms

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GOName
GO:0002755 MyD88-dependent toll-like receptor signaling pathway
GO:0004672 protein kinase activity
GO:0004674 protein serine/threonine kinase activity
GO:0004709 MAP kinase kinase kinase activity
GO:0005524 ATP binding
GO:0005829 cytosol
GO:0006468 protein phosphorylation
GO:0008270 zinc ion binding
GO:0019901 protein kinase binding
GO:0038095 Fc-epsilon receptor signaling pathway
GO:0071260 cellular response to mechanical stimulus
GO:0106310 protein serine kinase activity
GO:0106311 protein threonine kinase activity

Subcellular Location

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Domains

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DomainNameCategoryType
IPR000719 Protein kinase domainDomainDomain
IPR001841 Zinc finger, RING-typeDomainDomain
IPR007527 Zinc finger, SWIM-typeDomainDomain
IPR008271 Serine/threonine-protein kinase, active siteSiteActive site
IPR011009 Protein kinase-like domain superfamilyFamilyHomologous superfamily
IPR011989 Armadillo-like helicalFamilyHomologous superfamily
IPR013083 Zinc finger, RING/FYVE/PHD-typeFamilyHomologous superfamily
IPR016024 Armadillo-type foldFamilyHomologous superfamily
IPR017441 Protein kinase, ATP binding siteSiteBinding site

Diseases

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Drugs

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DrugNameSourceType
DB06061 AZD-8330Drugbanksmall molecule
DB11967 BinimetinibDrugbanksmall molecule
DB12010 FostamatinibDrugbanksmall molecule

Interactions

207 interactions

InteractorPartnerSourcesPublicationsLink
M3K1_HUMAN1433E_HUMANBioGRID, IntAct, MINT14743216 9452471 details
M3K1_HUMANM4K2_HUMANBioGRID, IntAct11784851 9712898 details
M3K1_HUMANM3K1_HUMANBioGRID, IntAct11784851 12624112 14743216 details
M3K1_HUMANDCAF7_HUMANBioGRID, IntAct, MINT14743216 20940704 25342745 details
M3K1_HUMANMP2K4_HUMANBioGRID, IntAct10713157 12228228 14500727 14581471 15299005 15866172 16472679 27806347 9808624 details
M3K1_HUMANESR1_HUMANMINT15556606 details
M3K1_HUMANIKKB_HUMANBioGRID, IntAct11057907 16286467 9819420 details
M3K1_HUMANBRAF_HUMANMINT16810323 16888650 details
M3K1_HUMANTRAF2_HUMANBioGRID, IntAct10346818 16636664 25241761 25260751 32041822 details
M3K1_HUMANMP2K7_HUMANBioGRID, MINT14500727 15866172 17110930 details
M3K1_HUMANUB2D1_HUMANBioGRID, IntAct19690564 details
M3K1_HUMANUB2D2_HUMANBioGRID, IntAct19690564 details
M3K1_HUMANUB2D3_HUMANBioGRID, IntAct19690564 details
M3K1_HUMANUB2D4_HUMANBioGRID, IntAct19690564 details
M3K1_HUMANUB2E1_HUMANBioGRID, IntAct19690564 details
M3K1_HUMANUB2L6_HUMANBioGRID, IntAct19690564 details
M3K1_HUMANUBE2W_HUMANBioGRID, IntAct19690564 details
M3K1_HUMANMK08_HUMANBioGRID, IntAct12228228 14500727 15299005 21152872 25241761 9405400 details
M3K1_HUMANMK03_HUMANBioGRID, IntAct24135036 25241761 details
M3K1_HUMANACM5_HUMANBioGRID, MINT28298427 details
M3K1_HUMANUBC9_HUMANBioGRID21336309 9563508 details
M3K1_HUMANRAF1_HUMANBioGRID, HPRD10969079 details
M3K1_HUMANMK01_HUMANBioGRID, HPRD10969079 14500727 14581471 24135036 details
M3K1_HUMANGRB2_HUMANBioGRID15192046 9733714 details
M3K1_HUMANDTX1_HUMANBioGRID15684388 details
M3K1_HUMANRHOA_HUMANBioGRID14581471 21129722 24135036 details
M3K1_HUMANACTN1_HUMANBioGRID14581471 details
M3K1_HUMANRHG04_HUMANBioGRID14581471 details
M3K1_HUMANMK09_HUMANBioGRID12228228 14581471 details
M3K1_HUMANIKKA_HUMANBioGRID16286467 9689078 9819420 details
M3K1_HUMANP53_HUMANBioGRID20923779 26018553 details
M3K1_HUMANIKBA_HUMANBioGRID14500727 details
M3K1_HUMANNR4A1_HUMANBioGRID16434970 details
M3K1_HUMANJUN_HUMANBioGRID12796506 26237449 details
M3K1_HUMANGSK3B_HUMANBioGRID12584189 details
M3K1_HUMANCRTC1_HUMANBioGRID18784253 details
M3K1_HUMANPAK1_HUMANBioGRID12228228 details
M3K1_HUMANBRCA1_HUMANBioGRID22990118 details
M3K1_HUMANBAP1_HUMANBioGRID25260751 details
M3K1_HUMANFKBP6_HUMANBioGRID25260751 details
M3K1_HUMANNPL4_HUMANBioGRID25260751 details
M3K1_HUMANASCC2_HUMANBioGRID25260751 details
M3K1_HUMANUB2V1_HUMANBioGRID25260751 details
M3K1_HUMANUBAC1_HUMANBioGRID25260751 details
M3K1_HUMANDNJB6_HUMANBioGRID25260751 details
M3K1_HUMANTM1L2_HUMANBioGRID25260751 details
M3K1_HUMANCUED1_HUMANBioGRID25260751 details
M3K1_HUMANHBS1L_HUMANBioGRID25260751 details
M3K1_HUMANDP13A_HUMANBioGRID25260751 details
M3K1_HUMANZFAN5_HUMANBioGRID25260751 details
M3K1_HUMANTOM1_HUMANBioGRID25260751 details
M3K1_HUMANRD23A_HUMANBioGRID25260751 details
M3K1_HUMANSTAM1_HUMANBioGRID25260751 details
M3K1_HUMANHG2A_HUMANBioGRID25260751 details
M3K1_HUMANHIP1_HUMANBioGRID25260751 details
M3K1_HUMANUBXN7_HUMANBioGRID25260751 details
M3K1_HUMANHGS_HUMANBioGRID25260751 details
M3K1_HUMANILRUN_HUMANBioGRID25260751 details
M3K1_HUMANR3GEF_HUMANBioGRID25260751 details
M3K1_HUMANUBS3B_HUMANBioGRID25260751 details
M3K1_HUMANTAB1_HUMANBioGRID25260751 details
M3K1_HUMANDNJB2_HUMANBioGRID25260751 details
M3K1_HUMANRN141_HUMANBioGRID25260751 details
M3K1_HUMANMINY3_HUMANBioGRID25260751 details
M3K1_HUMANUBAP1_HUMANBioGRID25260751 details
M3K1_HUMANDCNL1_HUMANBioGRID25260751 details
M3K1_HUMANNEK10_HUMANBioGRID25260751 details
M3K1_HUMANSTAM2_HUMANBioGRID25260751 details
M3K1_HUMANGRAP1_HUMANBioGRID25260751 details
M3K1_HUMANEPHA1_HUMANBioGRID25260751 details
M3K1_HUMANRAD18_HUMANBioGRID25260751 details
M3K1_HUMANHOIL1_HUMANBioGRID25260751 details
M3K1_HUMANIMPCT_HUMANBioGRID25260751 details
M3K1_HUMANPSMD4_HUMANBioGRID25260751 details
M3K1_HUMANSPART_HUMANBioGRID25260751 details
M3K1_HUMANZFAN3_HUMANBioGRID25260751 details
M3K1_HUMANEPN1_HUMANBioGRID25260751 details
M3K1_HUMANRN114_HUMANBioGRID25260751 details
M3K1_HUMANUB2G1_HUMANBioGRID25260751 details
M3K1_HUMANDCNL2_HUMANBioGRID25260751 details
M3K1_HUMANUCHL5_HUMANBioGRID25260751 details
M3K1_HUMANCREL1_HUMANBioGRID25260751 details
M3K1_HUMANATX3_HUMANBioGRID25260751 details
M3K1_HUMANFAF2_HUMANBioGRID25260751 details
M3K1_HUMANCEP85_HUMANBioGRID25260751 details
M3K1_HUMANUFD1_HUMANBioGRID25260751 details
M3K1_HUMANUBE2K_HUMANBioGRID25260751 details
M3K1_HUMANUBP28_HUMANBioGRID25260751 details
M3K1_HUMANF184A_HUMANBioGRID25260751 details
M3K1_HUMANGGA2_HUMANBioGRID25260751 details
M3K1_HUMANPKHB2_HUMANBioGRID25260751 details
M3K1_HUMANKRT36_HUMANBioGRID25260751 details
M3K1_HUMANRN126_HUMANBioGRID25260751 details
M3K1_HUMANAPEX2_HUMANBioGRID25260751 details
M3K1_HUMANODFP2_HUMANBioGRID25260751 details
M3K1_HUMANDEN6B_HUMANBioGRID25260751 details
M3K1_HUMANCAR14_HUMANBioGRID25260751 details
M3K1_HUMANUBQL1_HUMANBioGRID25260751 details
M3K1_HUMANCCD69_HUMANBioGRID25260751 details
M3K1_HUMANRABE2_HUMANBioGRID25260751 details
M3K1_HUMANR51A1_HUMANBioGRID25260751 details
M3K1_HUMANTNIP1_HUMANBioGRID25260751 details
M3K1_HUMANMBP_HUMANBioGRID12624112 details
M3K1_HUMANCSN6_HUMANBioGRID26237449 details
M3K1_HUMANNOTC1_HUMANBioGRID27806347 details
M3K1_HUMANBAALC_HUMANBioGRID26050649 details
M3K1_HUMANBAG2_HUMANIntAct14743216 details
M3K1_HUMANAIFM1_HUMANIntAct14743216 details
M3K1_HUMANTCPQ_HUMANIntAct14743216 details
M3K1_HUMANHS71L_HUMANBioGRID, IntAct14743216 25241761 details
M3K1_HUMANBIP_HUMANIntAct14743216 details
M3K1_HUMANHSP7C_HUMANIntAct14743216 details
M3K1_HUMANRS27L_HUMANIntAct14743216 details
M3K1_HUMANADT2_HUMANIntAct14743216 details
M3K1_HUMANBAG5_HUMANIntAct14743216 details
M3K1_HUMANGRP75_HUMANIntAct14743216 details
M3K1_HUMANSYMC_HUMANIntAct14743216 details
M3K1_HUMANRLA2_HUMANIntAct14743216 details
M3K1_HUMANRUVB2_HUMANIntAct14743216 details
M3K1_HUMANTCPE_HUMANIntAct14743216 details
M3K1_HUMANEPIPL_HUMANIntAct14743216 details
M3K1_HUMANHSP76_HUMANIntAct14743216 details
M3K1_HUMANDNJA1_HUMANIntAct14743216 details
M3K1_HUMANEF1A2_HUMANIntAct14743216 details
M3K1_HUMANDHE3_HUMANIntAct14743216 details
M3K1_HUMANTCPA_HUMANIntAct14743216 details
M3K1_HUMANSSRD_HUMANIntAct14743216 details
M3K1_HUMANAAAT_HUMANIntAct14743216 details
M3K1_HUMANMYH10_HUMANIntAct14743216 details
M3K1_HUMANPYR1_HUMANIntAct14743216 details
M3K1_HUMANIRS4_HUMANIntAct14743216 details
M3K1_HUMANACTG_HUMANIntAct14743216 details
M3K1_HUMANRS6_HUMANIntAct14743216 details
M3K1_HUMANRL3_HUMANIntAct14743216 details
M3K1_HUMANECHB_HUMANIntAct14743216 details
M3K1_HUMANTIM50_HUMANIntAct14743216 details
M3K1_HUMANLG3BP_HUMANIntAct14743216 details
M3K1_HUMANRS11_HUMANIntAct14743216 details
M3K1_HUMANRS14_HUMANIntAct14743216 details
M3K1_HUMANFAS_HUMANIntAct14743216 details
M3K1_HUMANTCPG_HUMANIntAct14743216 details
M3K1_HUMANTCPZ_HUMANIntAct14743216 details
M3K1_HUMANGEMI4_HUMANIntAct14743216 details
M3K1_HUMANRCN2_HUMANIntAct14743216 details
M3K1_HUMANRL35A_HUMANIntAct14743216 details
M3K1_HUMANRL7_HUMANIntAct14743216 details
M3K1_HUMANTBB2B_HUMANIntAct14743216 details
M3K1_HUMANECHA_HUMANIntAct14743216 details
M3K1_HUMANTBB6_HUMANIntAct14743216 details
M3K1_HUMANRL14_HUMANIntAct14743216 details
M3K1_HUMANHPBP1_HUMANIntAct14743216 details
M3K1_HUMANCALM2_HUMANIntAct14743216 details
M3K1_HUMANTBB8_HUMANIntAct14743216 details
M3K1_HUMANTBB5_HUMANIntAct14743216 details
M3K1_HUMANTBB4A_HUMANIntAct14743216 details
M3K1_HUMANRS27_HUMANIntAct14743216 details
M3K1_HUMANRLA0L_HUMANIntAct14743216 details
M3K1_HUMANDNJA3_HUMANIntAct14743216 details
M3K1_HUMANFLNA_HUMANIntAct14743216 details
M3K1_HUMANDHX9_HUMANIntAct14743216 details
M3K1_HUMANRL18_HUMANIntAct14743216 details
M3K1_HUMANRL37A_HUMANIntAct14743216 details
M3K1_HUMANVIME_HUMANIntAct14743216 details
M3K1_HUMANUBB_HUMANIntAct14743216 details
M3K1_HUMANH4_HUMANIntAct14743216 details
M3K1_HUMANRS8_HUMANIntAct14743216 details
M3K1_HUMANNOP2_HUMANIntAct14743216 details
M3K1_HUMANADT3_HUMANIntAct14743216 details
M3K1_HUMANRS4X_HUMANIntAct14743216 details
M3K1_HUMANNUCL_HUMANIntAct14743216 details
M3K1_HUMANRS23_HUMANIntAct14743216 details
M3K1_HUMANRL35_HUMANIntAct14743216 details
M3K1_HUMANDDB1_HUMANIntAct14743216 details
M3K1_HUMANHS105_HUMANIntAct14743216 details
M3K1_HUMANTBA3C_HUMANIntAct14743216 details
M3K1_HUMANTBA3D_HUMANIntAct14743216 details
M3K1_HUMANRL13_HUMANIntAct14743216 details
M3K1_HUMANHNRPM_HUMANIntAct14743216 details
M3K1_HUMANRL10A_HUMANIntAct14743216 details
M3K1_HUMANRL10_HUMANIntAct14743216 details
M3K1_HUMANTCPD_HUMANIntAct14743216 details
M3K1_HUMANRL24_HUMANIntAct14743216 details
M3K1_HUMANRUXF_HUMANIntAct14743216 details
M3K1_HUMANHS90B_HUMANIntAct14743216 details
M3K1_HUMANUSP9X_HUMANIntAct14743216 details
M3K1_HUMANRS9_HUMANIntAct14743216 details
M3K1_HUMANRS16_HUMANIntAct14743216 details
M3K1_HUMANMYLK2_HUMANIntAct14743216 details
M3K1_HUMANMYO1D_HUMANIntAct14743216 details
M3K1_HUMANTBA1A_HUMANIntAct14743216 details
M3K1_HUMANHS90A_HUMANIntAct14743216 details
M3K1_HUMANUBC_HUMANMINT16845370 details
M3K1_HUMANMP2K1_HUMANBioGRID, MINT10969079 14500727 17110930 details
M3K1_HUMANFLNB_HUMANBioGRID, MINT19270716 details
M3K1_HUMANAXIN1_HUMANBioGRID, IntAct10829020 11884395 20128690 22682247 24135036 details
M3K1_HUMANM4K4_HUMANBioGRID9135144 details
M3K1_HUMANDVL2_HUMANBioGRID10829020 details
M3K1_HUMANJIP3_HUMANBioGRID10523642 details
M3K1_HUMANALK_HUMANBioGRID14968112 details
M3K1_HUMANGSTP1_HUMANBioGRID16636664 details
M3K1_HUMAN1433T_HUMANBioGRID21152872 details
M3K1_HUMAN1433G_HUMANBioGRID21152872 details
M3K1_HUMANSTK38_HUMANBioGRID17906693 29969578 details
M3K1_HUMANTRIM5_HUMANBioGRID21512573 details
M3K1_HUMANKAT5_HUMANBioGRID16469706 details
M3K1_HUMANFRAT1_HUMANBioGRID24135036 details
M3K1_HUMANTNR5_HUMANBioGRID32041822 details