Entity Details

Primary name STIM1_HUMAN
Entity type UniProt
Source Source Link

Details

AccessionQ13586
EntryNameSTIM1_HUMAN
FullNameStromal interaction molecule 1
TaxID9606
Evidenceevidence at protein level
Length685
SequenceStatuscomplete
DateCreated2001-11-02
DateModified2021-06-02

Ontological Relatives

GenesSTIM1

GO terms

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GOName
GO:0002020 protease binding
GO:0002115 store-operated calcium entry
GO:0005246 calcium channel regulator activity
GO:0005509 calcium ion binding
GO:0005513 detection of calcium ion
GO:0005783 endoplasmic reticulum
GO:0005789 endoplasmic reticulum membrane
GO:0005874 microtubule
GO:0005886 plasma membrane
GO:0005887 integral component of plasma membrane
GO:0006874 cellular calcium ion homeostasis
GO:0030176 integral component of endoplasmic reticulum membrane
GO:0032237 activation of store-operated calcium channel activity
GO:0032541 cortical endoplasmic reticulum
GO:0033017 sarcoplasmic reticulum membrane
GO:0042802 identical protein binding
GO:0044853 plasma membrane raft
GO:0045762 positive regulation of adenylate cyclase activity
GO:0045766 positive regulation of angiogenesis
GO:0051010 microtubule plus-end binding
GO:0051924 regulation of calcium ion transport
GO:0070166 enamel mineralization
GO:1903779 regulation of cardiac conduction
GO:2001256 regulation of store-operated calcium entry

Subcellular Location

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Subcellular Location
Cell membrane
Cytoplasm
Endoplasmic reticulum membrane
Sarcoplasmic reticulum

Domains

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DomainNameCategoryType
IPR001660 Sterile alpha motif domainDomainDomain
IPR013761 Sterile alpha motif/pointed domain superfamilyFamilyHomologous superfamily
IPR030463 Stromal interaction molecule 1FamilyFamily
IPR032393 Stromal interaction molecule, Orai1-activating regionDomainDomain
IPR037608 Stromal interaction moleculeFamilyFamily
IPR037609 Stromal interaction molecule 1, SAM domainDomainDomain

Diseases

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Interactions

29 interactions

InteractorPartnerSourcesPublicationsLink
STIM1_HUMANSTIM1_HUMANDIP, HPRD, IntAct, MINT, UniProt11983428 17517596 19249086 20418871 21427704 22451904 24996186 details
STIM1_HUMANKAT5_HUMANIntAct32814053 details
STIM1_HUMANCRCM1_HUMANDIP, IntAct, MINT, UniProt19249086 19706554 20418871 21427704 21876174 22451904 22464749 24954132 24996186 details
STIM1_HUMANEFC4B_HUMANUniProt20418871 details
STIM1_HUMANINGR1_HUMANBioGRID, IntAct32296183 details
STIM1_HUMANPPIB_HUMANIntAct32814053 details
STIM1_HUMANSL7A1_HUMANBioGRID, IntAct32296183 details
STIM1_HUMANFGFR3_HUMANIntAct32814053 details
STIM1_HUMANRASH_HUMANIntAct32814053 details
STIM1_HUMAN1433G_HUMANIntAct32814053 details
STIM1_HUMANINSI2_HUMANBioGRID, IntAct32296183 details
STIM1_HUMANPRAF1_HUMANBioGRID, IntAct32296183 details
STIM1_HUMANUBQL1_HUMANIntAct32814053 details
STIM1_HUMANSETB1_HUMANIntAct32814053 details
STIM1_HUMANOPTN_HUMANIntAct32814053 details
STIM1_HUMANPPIA_HUMANIntAct32814053 details
STIM1_HUMANLMO3_HUMANIntAct32814053 details
STIM1_HUMANPDIA3_HUMANMINT21941299 details
STIM1_HUMANNMDE3_HUMANIntAct32814053 details
STIM1_HUMANORAI3_HUMANDIP19706554 details
STIM1_HUMANSTIM2_HUMANBioGRID, HPRD, IntAct11463338 28514442 34079125 details
STIM1_HUMANMARE1_HUMANBioGRID, IntAct19632184 23698468 34079125 details
STIM1_HUMANSARAF_HUMANIntAct22464749 details
STIM1_HUMANORAI2_HUMANDIP19706554 details
STIM1_HUMANST7_HUMANBioGRID29395067 details
STIM1_HUMANEXOC5_HUMANBioGRID, IntAct27173435 unassigned1312 details
STIM1_HUMANAT2B4_HUMANMINT22246182 details
STIM1_HUMANTRPC1_HUMANDIP19897728 21408196 details
STIM1_HUMANAT2C1_HUMANIntAct20887894 details