Entity Details

Primary name 5HT4R_HUMAN
Entity type UniProt
Source Source Link

Details

AccessionQ13639
EntryName5HT4R_HUMAN
FullName5-hydroxytryptamine receptor 4
TaxID9606
Evidenceevidence at protein level
Length388
SequenceStatuscomplete
DateCreated1997-11-01
DateModified2021-06-02

Ontological Relatives

GenesHTR4

GO terms

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GOName
GO:0002862 negative regulation of inflammatory response to antigenic stimulus
GO:0004993 G protein-coupled serotonin receptor activity
GO:0005737 cytoplasm
GO:0005768 endosome
GO:0005886 plasma membrane
GO:0005887 integral component of plasma membrane
GO:0007186 G protein-coupled receptor signaling pathway
GO:0007187 G protein-coupled receptor signaling pathway, coupled to cyclic nucleotide second messenger
GO:0007198 adenylate cyclase-inhibiting serotonin receptor signaling pathway
GO:0007268 chemical synaptic transmission
GO:0016020 membrane
GO:0030425 dendrite
GO:0030594 neurotransmitter receptor activity
GO:0032098 regulation of appetite
GO:0045202 synapse
GO:0051378 serotonin binding

Subcellular Location

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Subcellular Location
Cell membrane
Endosome

Domains

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DomainNameCategoryType
IPR000276 G protein-coupled receptor, rhodopsin-likeFamilyFamily
IPR001520 5-Hydroxytryptamine 4 receptorFamilyFamily
IPR017452 GPCR, rhodopsin-like, 7TMDomainDomain

Diseases

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Drugs

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DrugNameSourceType
DB00604 CisaprideDrugbanksmall molecule
DB00715 ParoxetineDrugbanksmall molecule
DB00904 OndansetronDrugbanksmall molecule
DB01049 Ergoloid mesylateDrugbanksmall molecule
DB01079 TegaserodDrugbanksmall molecule
DB01233 MetoclopramideDrugbanksmall molecule
DB01239 ChlorprothixeneDrugbanksmall molecule
DB04873 PiboserodDrugbanksmall molecule
DB04917 RenzaprideDrugbanksmall molecule
DB05542 NaronaprideDrugbanksmall molecule
DB05905 TD-2749Drugbanksmall molecule
DB06422 TicaloprideDrugbanksmall molecule
DB06480 PrucaloprideDrugbanksmall molecule
DB08810 CinitaprideDrugbanksmall molecule
DB09304 SetiptilineDrugbanksmall molecule
DB11273 DihydroergocornineDrugbanksmall molecule
DB12141 GilteritinibDrugbanksmall molecule
DB12702 VelusetragDrugbanksmall molecule
DB13025 TiaprideDrugbanksmall molecule
DB13345 DihydroergocristineDrugbanksmall molecule