Entity Details

Primary name RPGF1_HUMAN
Entity type UniProt
Source Source Link

Details

AccessionQ13905
EntryNameRPGF1_HUMAN
FullNameRap guanine nucleotide exchange factor 1
TaxID9606
Evidenceevidence at protein level
Length1077
SequenceStatuscomplete
DateCreated2002-11-15
DateModified2021-06-02

Ontological Relatives

GenesRAPGEF1

GO terms

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GOName
GO:0000186 obsolete activation of MAPKK activity
GO:0001568 blood vessel development
GO:0005085 guanyl-nucleotide exchange factor activity
GO:0005737 cytoplasm
GO:0005769 early endosome
GO:0005829 cytosol
GO:0007165 signal transduction
GO:0007169 transmembrane receptor protein tyrosine kinase signaling pathway
GO:0007399 nervous system development
GO:0010976 positive regulation of neuron projection development
GO:0017124 SH3 domain binding
GO:0019221 cytokine-mediated signaling pathway
GO:0030670 phagocytic vesicle membrane
GO:0032486 Rap protein signal transduction
GO:0032991 protein-containing complex
GO:0038180 nerve growth factor signaling pathway
GO:0043231 intracellular membrane-bounded organelle
GO:0043547 positive regulation of GTPase activity
GO:0046328 regulation of JNK cascade
GO:0046579 positive regulation of Ras protein signal transduction
GO:0046580 negative regulation of Ras protein signal transduction
GO:0048008 platelet-derived growth factor receptor signaling pathway
GO:0048471 perinuclear region of cytoplasm
GO:0051898 negative regulation of protein kinase B signaling
GO:0061028 establishment of endothelial barrier
GO:0070373 negative regulation of ERK1 and ERK2 cascade
GO:0070374 positive regulation of ERK1 and ERK2 cascade
GO:0071320 cellular response to cAMP
GO:0090090 negative regulation of canonical Wnt signaling pathway
GO:0090630 activation of GTPase activity
GO:0098609 cell-cell adhesion
GO:1901888 regulation of cell junction assembly
GO:1905451 positive regulation of Fc-gamma receptor signaling pathway involved in phagocytosis
GO:1990090 cellular response to nerve growth factor stimulus
GO:2000178 negative regulation of neural precursor cell proliferation

Subcellular Location

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Subcellular Location
Early endosome

Domains

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DomainNameCategoryType
IPR000651 Ras-like guanine nucleotide exchange factor, N-terminalDomainDomain
IPR001895 Ras guanine-nucleotide exchange factors catalytic domainDomainDomain
IPR008937 Ras-like guanine nucleotide exchange factorFamilyFamily
IPR019804 Ras guanine-nucleotide exchange factor, conserved siteSiteConserved site
IPR023578 Ras guanine nucleotide exchange factor domain superfamilyFamilyHomologous superfamily
IPR036964 Ras guanine-nucleotide exchange factor, catalytic domain superfamilyFamilyHomologous superfamily

Diseases

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Interactions

25 interactions

InteractorPartnerSourcesPublicationsLink
RPGF1_HUMANCRK_HUMANBioGRID, DIP, HPRD, IntAct, MINT10464310 11870224 12054111 17474147 17515907 18835194 19001122 19380743 31980649 7512734 7531694 8621483 8943292 9564038 details
RPGF1_HUMANGRB2_HUMANBioGRID, HPRD, IntAct, MINT20936779 7512734 8621483 8943292 details
RPGF1_HUMANABL1_HUMANBioGRID, IntAct, MINT16443220 17474147 details
RPGF1_HUMANSRC_HUMANIntAct17474147 details
RPGF1_HUMANFYN_HUMANIntAct17474147 details
RPGF1_HUMANNCK1_HUMANIntAct17474147 details
RPGF1_HUMANP85A_HUMANIntAct17474147 details
RPGF1_HUMANCRKL_HUMANBioGRID, HPRD, IntAct, MINT10608804 10753869 10907644 11167825 11466412 16443220 18835194 26496610 30480076 8621483 8978305 9129019 9311917 9344843 9374471 9820532 details
RPGF1_HUMANRS15_HUMANBioGRID, IntAct21988832 details
RPGF1_HUMANS20A1_HUMANBioGRID, IntAct21988832 details
RPGF1_HUMANMBIP1_HUMANBioGRID, IntAct21988832 details
RPGF1_HUMANATX1_HUMANBioGRID, IntAct23275563 details
RPGF1_HUMANEGFR_HUMANBioGRID, IntAct24658140 25402006 31980649 details
RPGF1_HUMANRAP1A_HUMANBioGRID, DIP22081014 9266971 details
RPGF1_HUMANBCAR1_HUMANBioGRID, HPRD9748234 details
RPGF1_HUMANHCK_HUMANBioGRID, HPRD10318861 12734187 14551197 details
RPGF1_HUMANRAP2B_HUMANBioGRID9266971 details
RPGF1_HUMANCTLA4_HUMANMINT24396067 details
RPGF1_HUMANCASL_HUMANBioGRID, HPRD9497377 9498705 details
RPGF1_HUMANSHC1_HUMANBioGRID, HPRD9344843 details
RPGF1_HUMANCBL_HUMANBioGRID10608804 18835194 details
RPGF1_HUMANRASH_HUMANBioGRID, HPRD10514505 30639242 details
RPGF1_HUMANRRAS2_HUMANHPRD12384139 details
RPGF1_HUMANRAP1B_HUMANHPRD8524240 details
RPGF1_HUMANRHOQ_HUMANHPRD11309621 details