Entity Details

Primary name IL18_HUMAN
Entity type UniProt
Source Source Link

Details

AccessionQ14116
EntryNameIL18_HUMAN
FullNameInterleukin-18
TaxID9606
Evidenceevidence at protein level
Length193
SequenceStatuscomplete
DateCreated1998-07-15
DateModified2021-06-02

Ontological Relatives

GenesIL18

GO terms

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GOName
GO:0000165 MAPK cascade
GO:0001525 angiogenesis
GO:0005125 cytokine activity
GO:0005576 extracellular region
GO:0005615 extracellular space
GO:0005829 cytosol
GO:0006954 inflammatory response
GO:0007267 cell-cell signaling
GO:0008283 cell population proliferation
GO:0010744 positive regulation of macrophage derived foam cell differentiation
GO:0014068 positive regulation of phosphatidylinositol 3-kinase signaling
GO:0019221 cytokine-mediated signaling pathway
GO:0030101 natural killer cell activation
GO:0030155 regulation of cell adhesion
GO:0030431 sleep
GO:0031663 lipopolysaccharide-mediated signaling pathway
GO:0032148 activation of protein kinase B activity
GO:0032722 positive regulation of chemokine production
GO:0032725 positive regulation of granulocyte macrophage colony-stimulating factor production
GO:0032729 positive regulation of interferon-gamma production
GO:0032736 positive regulation of interleukin-13 production
GO:0032740 positive regulation of interleukin-17 production
GO:0032819 positive regulation of natural killer cell proliferation
GO:0034105 positive regulation of tissue remodeling
GO:0035590 purinergic nucleotide receptor signaling pathway
GO:0035655 interleukin-18-mediated signaling pathway
GO:0042088 T-helper 1 type immune response
GO:0042092 type 2 immune response
GO:0042104 positive regulation of activated T cell proliferation
GO:0042119 neutrophil activation
GO:0042267 natural killer cell mediated cytotoxicity
GO:0042531 positive regulation of tyrosine phosphorylation of STAT protein
GO:0042632 cholesterol homeostasis
GO:0045515 interleukin-18 receptor binding
GO:0045630 positive regulation of T-helper 2 cell differentiation
GO:0045662 negative regulation of myoblast differentiation
GO:0045944 positive regulation of transcription by RNA polymerase II
GO:0048661 positive regulation of smooth muscle cell proliferation
GO:0050729 positive regulation of inflammatory response
GO:0051092 positive regulation of NF-kappaB transcription factor activity
GO:0051142 positive regulation of NK T cell proliferation
GO:0051897 positive regulation of protein kinase B signaling
GO:0070328 triglyceride homeostasis
GO:0071407 cellular response to organic cyclic compound
GO:0120162 positive regulation of cold-induced thermogenesis
GO:0150078 positive regulation of neuroinflammatory response
GO:1901224 positive regulation of NIK/NF-kappaB signaling
GO:2000556 positive regulation of T-helper 1 cell cytokine production

Subcellular Location

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Subcellular Location
Cytoplasm
Secreted

Domains

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DomainNameCategoryType
IPR000975 Interleukin-1 familyFamilyFamily
IPR008996 Cytokine IL1/FGFFamilyHomologous superfamily
IPR015529 Interleukin-18FamilyFamily

Diseases

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