Entity Details

Primary name E2F2_HUMAN
Entity type UniProt
Source Source Link

Details

AccessionQ14209
EntryNameE2F2_HUMAN
FullNameTranscription factor E2F2
TaxID9606
Evidenceevidence at protein level
Length437
SequenceStatuscomplete
DateCreated1997-11-01
DateModified2021-06-02

Ontological Relatives

GenesE2F2

GO terms

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GOName
GO:0000785 chromatin
GO:0000978 RNA polymerase II cis-regulatory region sequence-specific DNA binding
GO:0000981 DNA-binding transcription factor activity, RNA polymerase II-specific
GO:0000987 cis-regulatory region sequence-specific DNA binding
GO:0001228 DNA-binding transcription activator activity, RNA polymerase II-specific
GO:0003677 DNA binding
GO:0003700 DNA-binding transcription factor activity
GO:0005654 nucleoplasm
GO:0006357 regulation of transcription by RNA polymerase II
GO:0006367 transcription initiation from RNA polymerase II promoter
GO:0007049 cell cycle
GO:0008134 transcription factor binding
GO:0043565 sequence-specific DNA binding
GO:0045944 positive regulation of transcription by RNA polymerase II
GO:0046983 protein dimerization activity
GO:0051726 regulation of cell cycle
GO:0072332 intrinsic apoptotic signaling pathway by p53 class mediator
GO:0090575 RNA polymerase II transcription regulator complex
GO:1903671 negative regulation of sprouting angiogenesis
GO:1990086 lens fiber cell apoptotic process
GO:1990837 sequence-specific double-stranded DNA binding

Subcellular Location

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Subcellular Location
Nucleus

Domains

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DomainNameCategoryType
IPR003316 E2F/DP family, winged-helix DNA-binding domainDomainDomain
IPR015633 E2F FamilyFamilyFamily
IPR032198 E2F transcription factor, CC-MB domainDomainDomain
IPR036388 Winged helix-like DNA-binding domain superfamilyFamilyHomologous superfamily
IPR036390 Winged helix DNA-binding domain superfamilyFamilyHomologous superfamily
IPR037241 E2F-DP heterodimerization regionFamilyHomologous superfamily

Diseases

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Interactions

26 interactions

InteractorPartnerSourcesPublicationsLink
E2F2_HUMANBCAR1_HUMANBioGRID, HPRD, IntAct16169070 details
E2F2_HUMANRB_HUMANBioGRID, HPRD, IntAct, MINT12502741 16360038 17380128 24981860 31130363 7739537 8246996 8657117 8832394 details
E2F2_HUMANGIT2_HUMANBioGRID, IntAct21988832 details
E2F2_HUMANGNB5_HUMANBioGRID, IntAct21988832 details
E2F2_HUMANTFDP1_HUMANBioGRID, HPRD, IntAct, MINT20211142 24981860 27705803 31130363 7739537 8755520 8832394 details
E2F2_HUMANTFDP2_HUMANBioGRID, HPRD, IntAct26186194 28514442 7739537 8755520 details
E2F2_HUMANSPIB_HUMANBioGRID12748276 details
E2F2_HUMANRYBP_HUMANBioGRID, HPRD12411495 details
E2F2_HUMANKMT5A_HUMANBioGRID, HPRD12411495 details
E2F2_HUMANR144A_HUMANBioGRID12411495 details
E2F2_HUMANFHL2_HUMANBioGRID12411495 details
E2F2_HUMANATAD2_HUMANBioGRID20855524 details
E2F2_HUMANGRB2_HUMANBioGRID25814554 details
E2F2_HUMANUCHL5_HUMANBioGRID26396186 details
E2F2_HUMANTYY1_HUMANHPRD12411495 details
E2F2_HUMANMCPH1_HUMANMINT18660752 details
E2F2_HUMANLMBL3_HUMANDIP17517653 details
E2F2_HUMANRBL1_HUMANBioGRID, IntAct20040599 8657117 details
E2F2_HUMANBRD2_HUMANBioGRID, HPRD10965846 12145330 details
E2F2_HUMANKMT2A_HUMANBioGRID16951254 details
E2F2_HUMANKMT2D_HUMANBioGRID16951254 details
E2F2_HUMANARI3A_HUMANBioGRID, HPRD15017387 details
E2F2_HUMANMYCN_HUMANBioGRID28209620 details
E2F2_HUMANCCNF_HUMANBioGRID31130363 details
E2F2_HUMANSP1_HUMANHPRD8657141 8657142 9694791 details
E2F2_HUMANCDK3_HUMANHPRD11733001 8846921 details