Entity Details

Primary name SIRT4
Entity type gene
Source Source Link

Details

PrimaryID23409
RefseqGene
SymbolSIRT4
Namesirtuin 4
Chromosome12
Location12q24.23-q24.31
TaxID9606
Statuslive
SourceGenomegenomic
SourceOriginnatural
CreationDate2001-03-22
ModificationDate2021-06-11

Ontological Relatives

UniProt IDsSIR4_HUMAN

GO terms

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GOName
GO:0000820 regulation of glutamine family amino acid metabolic process
GO:0003950 NAD+ ADP-ribosyltransferase activity
GO:0005739 mitochondrion
GO:0005743 mitochondrial inner membrane
GO:0005759 mitochondrial matrix
GO:0006471 protein ADP-ribosylation
GO:0006541 glutamine metabolic process
GO:0006974 cellular response to DNA damage stimulus
GO:0007005 mitochondrion organization
GO:0008270 zinc ion binding
GO:0010667 negative regulation of cardiac muscle cell apoptotic process
GO:0034983 peptidyl-lysine deacetylation
GO:0046322 negative regulation of fatty acid oxidation
GO:0046676 negative regulation of insulin secretion
GO:0046889 positive regulation of lipid biosynthetic process
GO:0047708 biotinidase activity
GO:0061690 lipoamidase activity
GO:0070403 NAD+ binding
GO:0071456 cellular response to hypoxia
GO:0072350 tricarboxylic acid metabolic process
GO:1903217 negative regulation of protein processing involved in protein targeting to mitochondrion
GO:1904182 regulation of pyruvate dehydrogenase activity

Diseases

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Interactions

113 interactions

InteractorPartnerSourcesPublicationsLink
SIRT4SKP2BioGRID, IntAct22770219 details
SIRT4PDHXIntAct25525879 details
SIRT4DLATIntAct25525879 details
SIRT4PTENBioGRID30649986 details
SIRT4IDEBioGRID, IntAct17715127 25525879 30649986 details
SIRT4SLC25A5BioGRID, IntAct17715127 details
SIRT4BCAT2BioGRID32467562 details
SIRT4SLC25A6BioGRID, IntAct17715127 details
SIRT4SIRT3BioGRID, IntAct17715127 details
SIRT4GPX1IntAct25525879 details
SIRT4VWA8IntAct25525879 details
SIRT4TUFMIntAct25525879 details
SIRT4TRAP1IntAct25525879 details
SIRT4TOMM40IntAct25525879 details
SIRT4THNSL1IntAct25525879 details
SIRT4TBRG4IntAct25525879 details
SIRT4SUCLG2IntAct25525879 details
SIRT4SUCLA2IntAct25525879 details
SIRT4STOML2IntAct25525879 details
SIRT4SHMT2IntAct25525879 details
SIRT4SHC1IntAct25525879 details
SIRT4SARS2IntAct25525879 details
SIRT4RARS2IntAct25525879 details
SIRT4PYCR2IntAct25525879 details
SIRT4PYCR1IntAct25525879 details
SIRT4PTCD3IntAct25525879 details
SIRT4PRDX5IntAct25525879 details
SIRT4PRDX3IntAct25525879 details
SIRT4PPA2IntAct25525879 details
SIRT4PMPCBIntAct25525879 details
SIRT4PMPCAIntAct25525879 details
SIRT4PITRM1IntAct25525879 details
SIRT4PDP1IntAct25525879 details
SIRT4PDHBIntAct25525879 details
SIRT4PDE12IntAct25525879 details
SIRT4PCK2IntAct25525879 details
SIRT4PCCAIntAct25525879 details
SIRT4PCIntAct25525879 details
SIRT4OGDHIntAct25525879 details
SIRT4NT5DC3IntAct25525879 details
SIRT4NT5DC2IntAct25525879 details
SIRT4NLRX1IntAct25525879 details
SIRT4NIT1IntAct25525879 details
SIRT4NDUFV1IntAct25525879 details
SIRT4NDUFS2IntAct25525879 details
SIRT4NDUFS1IntAct25525879 details
SIRT4NADK2IntAct25525879 details
SIRT4MTHFD1LIntAct25525879 details
SIRT4MRPS9IntAct25525879 details
SIRT4MRPS30IntAct25525879 details
SIRT4MRPS23IntAct25525879 details
SIRT4MRPS22IntAct25525879 details
SIRT4MRPS18BIntAct25525879 details
SIRT4MRPL44IntAct25525879 details
SIRT4MRPL39IntAct25525879 details
SIRT4MRPL37IntAct25525879 details
SIRT4MRPL28IntAct25525879 details
SIRT4MRPL1IntAct25525879 details
SIRT4MMAAIntAct25525879 details
SIRT4MLYCDIntAct25525879 details
SIRT4MIPEPIntAct25525879 details
SIRT4ME2IntAct25525879 details
SIRT4MCCC2IntAct25525879 details
SIRT4MCCC1IntAct25525879 details
SIRT4LRPPRCIntAct25525879 details
SIRT4LONP1IntAct25525879 details
SIRT4IVDIntAct25525879 details
SIRT4IDH2IntAct25525879 details
SIRT4IBA57IntAct25525879 details
SIRT4IARS2IntAct25525879 details
SIRT4HSPD1BioGRID, IntAct25525879 26186194 28514442 details
SIRT4HSD17B10IntAct25525879 details
SIRT4HMGCLIntAct25525879 details
SIRT4HDAC6IntAct25525879 details
SIRT4HADHAIntAct25525879 details
SIRT4GPT2IntAct25525879 details
SIRT4GLUD1IntAct25525879 details
SIRT4GCDHIntAct25525879 details
SIRT4GARS1IntAct25525879 details
SIRT4FLAD1IntAct25525879 details
SIRT4FASTKD5IntAct25525879 details
SIRT4ETHE1IntAct25525879 details
SIRT4ETFAIntAct25525879 details
SIRT4ECHS1IntAct25525879 details
SIRT4ECH1IntAct25525879 details
SIRT4DNPEPIntAct25525879 details
SIRT4DLSTIntAct25525879 details
SIRT4DLDIntAct25525879 details
SIRT4DHX30IntAct25525879 details
SIRT4DBTIntAct25525879 details
SIRT4DAP3IntAct25525879 details
SIRT4CYB5R1IntAct25525879 details
SIRT4CPOXIntAct25525879 details
SIRT4CNPIntAct25525879 details
SIRT4CLPXIntAct25525879 details
SIRT4HDHD5IntAct25525879 details
SIRT4C17orf80IntAct25525879 details
SIRT4BCKDHAIntAct25525879 details
SIRT4ALDH2IntAct25525879 details
SIRT4ALDH1L2IntAct25525879 details
SIRT4ALDH1L1IntAct25525879 details
SIRT4ALDH18A1IntAct25525879 details
SIRT4ALAS1IntAct25525879 details
SIRT4ACSF3IntAct25525879 details
SIRT4MRPL38IntAct25525879 details
SIRT4ACSF2IntAct25525879 details
SIRT4ACOT9IntAct25525879 details
SIRT4ACAT1IntAct25525879 details
SIRT4ACADVLIntAct25525879 details
SIRT4ACAD9IntAct25525879 details
SIRT4AARS2IntAct25525879 details
SIRT4SNX3BioGRID, IntAct26186194 28514442 details
SIRT4FANCABioGRID28215707 details