Entity Details

Primary name FLNC_HUMAN
Entity type UniProt
Source Source Link

Details

AccessionQ14315
EntryNameFLNC_HUMAN
FullNameFilamin-C
TaxID9606
Evidenceevidence at protein level
Length2725
SequenceStatuscomplete
DateCreated2003-06-16
DateModified2021-06-02

Ontological Relatives

GenesFLNC

GO terms

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GOName
GO:0003779 actin binding
GO:0005737 cytoplasm
GO:0005829 cytosol
GO:0005856 cytoskeleton
GO:0005886 plasma membrane
GO:0005925 focal adhesion
GO:0008092 cytoskeletal protein binding
GO:0016528 sarcoplasm
GO:0030018 Z disc
GO:0030506 ankyrin binding
GO:0034329 cell junction assembly
GO:0042383 sarcolemma
GO:0042802 identical protein binding
GO:0043034 costamere

Subcellular Location

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Subcellular Location
Cytoplasm
Membrane

Domains

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DomainNameCategoryType
IPR001298 Filamin/ABP280 repeatRepeatRepeat
IPR001589 Actinin-type actin-binding domain, conserved siteSiteConserved site
IPR001715 Calponin homology domainDomainDomain
IPR013783 Immunoglobulin-like foldFamilyHomologous superfamily
IPR014756 Immunoglobulin E-setFamilyHomologous superfamily
IPR017868 Filamin/ABP280 repeat-likeRepeatRepeat
IPR036872 CH domain superfamilyFamilyHomologous superfamily

Diseases

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Interactions

54 interactions

InteractorPartnerSourcesPublicationsLink
FLNC_HUMANSGCD_HUMANBioGRID, HPRD, MINT10629222 14506720 details
FLNC_HUMANSGCG_HUMANBioGRID, HPRD, MINT10629222 14506720 details
FLNC_HUMANMYOZ1_HUMANBioGRID, HPRD, MINT10984498 11171996 11842093 details
FLNC_HUMANADA1A_HUMANHPRD, IntAct15525470 details
FLNC_HUMANADA1D_HUMANHPRD, IntAct15525470 details
FLNC_HUMANADA1B_HUMANHPRD, IntAct15525470 details
FLNC_HUMANMYOTI_HUMANBioGRID, HPRD, IntAct11038172 details
FLNC_HUMANABL1_HUMANIntAct17474147 details
FLNC_HUMANCRK_HUMANIntAct17474147 details
FLNC_HUMANFYN_HUMANIntAct17474147 details
FLNC_HUMANGRB2_HUMANIntAct17474147 details
FLNC_HUMANNCK1_HUMANIntAct17474147 details
FLNC_HUMANP85A_HUMANIntAct17474147 details
FLNC_HUMANPLCG1_HUMANIntAct17474147 details
FLNC_HUMANTRI63_HUMANBioGRID, MINT18157088 details
FLNC_HUMANSMUF2_HUMANMINT18157088 details
FLNC_HUMANMLH1_HUMANIntAct20706999 details
FLNC_HUMANKS6A2_HUMANBioGRID, IntAct21988832 details
FLNC_HUMANDYSF_HUMANBioGRID, IntAct23414517 details
FLNC_HUMANENOA_HUMANBioGRID, IntAct22939629 23414517 details
FLNC_HUMANMYPC2_HUMANBioGRID, IntAct23414517 details
FLNC_HUMANREPS1_HUMANBioGRID, IntAct23414517 details
FLNC_HUMANXIRP1_HUMANBioGRID, IntAct16631741 23115302 details
FLNC_HUMANANK3_HUMANbhf-ucl, BioGRID21223964 details
FLNC_HUMANSYNEM_HUMANMINT25447537 details
FLNC_HUMANMYPC3_HUMANIntAct21569246 details
FLNC_HUMANHSPB2_HUMANbhf-ucl, BioGRID26465331 details
FLNC_HUMANFLNC_HUMANDIP15642266 details
FLNC_HUMANMP2K4_HUMANBioGRID, HPRD9006895 details
FLNC_HUMANCAN3_HUMANBioGRID, HPRD14506720 details
FLNC_HUMANKCND2_HUMANBioGRID, HPRD11102480 details
FLNC_HUMANPHLB2_HUMANBioGRID, HPRD12376540 details
FLNC_HUMANSHIP2_HUMANBioGRID, HPRD11739414 details
FLNC_HUMANUBP25_HUMANBioGRID16501887 details
FLNC_HUMANWNK1_HUMANBioGRID20936779 details
FLNC_HUMANAAKB2_HUMANBioGRID19616115 details
FLNC_HUMANTRI54_HUMANBioGRID17360532 details
FLNC_HUMANFXL22_HUMANBioGRID22972877 details
FLNC_HUMANXIRP2_HUMANBioGRID23115302 details
FLNC_HUMANSYNP2_HUMANBioGRID20554076 details
FLNC_HUMANTRI55_HUMANBioGRID18157088 details
FLNC_HUMANCDC42_HUMANBioGRID31478661 details
FLNC_HUMANFURIN_HUMANHPRD9412467 details
FLNC_HUMANNPHP1_HUMANHPRD12006559 details
FLNC_HUMANKY_HUMANHPRD15385448 details
FLNC_HUMANKPCA_HUMANHPRD12704190 details
FLNC_HUMANHIPK3_HUMANHPRD15231748 details
FLNC_HUMANTFIP8_HUMANIntAct17353931 details
FLNC_HUMANUBC9_HUMANIntAct20936779 details
FLNC_HUMANPAX4_HUMANIntAct28514442 details
FLNC_HUMANMYOZ2_HUMANBioGRID, HPRD11842093 details
FLNC_HUMANMYOZ3_HUMANBioGRID, HPRD11842093 details
FLNC_HUMANATOH1_HUMANBioGRID27542412 details
FLNC_HUMANSIAH2_HUMANBioGRID30063986 details