Entity Details

Primary name GPNMB_HUMAN
Entity type UniProt
Source Source Link

Details

AccessionQ14956
EntryNameGPNMB_HUMAN
FullNameTransmembrane glycoprotein NMB
TaxID9606
Evidenceevidence at protein level
Length572
SequenceStatuscomplete
DateCreated1997-11-01
DateModified2021-06-02

Ontological Relatives

GenesGPNMB

GO terms

Show/Hide Table
GOName
GO:0001818 negative regulation of cytokine production
GO:0001934 positive regulation of protein phosphorylation
GO:0005178 integrin binding
GO:0005886 plasma membrane
GO:0005887 integral component of plasma membrane
GO:0007155 cell adhesion
GO:0007165 signal transduction
GO:0007267 cell-cell signaling
GO:0008201 heparin binding
GO:0008285 negative regulation of cell population proliferation
GO:0016021 integral component of membrane
GO:0030335 positive regulation of cell migration
GO:0031901 early endosome membrane
GO:0031954 positive regulation of protein autophosphorylation
GO:0033162 melanosome membrane
GO:0034103 regulation of tissue remodeling
GO:0042056 chemoattractant activity
GO:0042130 negative regulation of T cell proliferation
GO:0045545 syndecan binding
GO:0045765 regulation of angiogenesis
GO:0048018 receptor ligand activity
GO:0050868 negative regulation of T cell activation
GO:0050918 positive chemotaxis
GO:0070374 positive regulation of ERK1 and ERK2 cascade
GO:1901215 negative regulation of neuron death
GO:2000134 negative regulation of G1/S transition of mitotic cell cycle

Subcellular Location

Show/Hide Table
Subcellular Location
Cell membrane
Early endosome membrane
Melanosome membrane

Domains

Show/Hide Table
DomainNameCategoryType
IPR000601 PKD domainDomainDomain
IPR013783 Immunoglobulin-like foldFamilyHomologous superfamily
IPR022409 PKD/Chitinase domainDomainDomain
IPR035986 PKD domain superfamilyFamilyHomologous superfamily

Diseases

Show/Hide Table

Drugs

Show/Hide Table
DrugNameSourceType
DB05996 Glembatumumab vedotinDrugbankbiotech