Entity Details

Primary name TESK1_HUMAN
Entity type UniProt
Source Source Link

Details

AccessionQ15569
EntryNameTESK1_HUMAN
FullNameDual specificity testis-specific protein kinase 1
TaxID9606
Evidenceevidence at protein level
Length626
SequenceStatuscomplete
DateCreated1997-11-01
DateModified2021-06-02

Ontological Relatives

GenesTESK1

GO terms

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GOName
GO:0001934 positive regulation of protein phosphorylation
GO:0004672 protein kinase activity
GO:0004674 protein serine/threonine kinase activity
GO:0004712 protein serine/threonine/tyrosine kinase activity
GO:0004714 transmembrane receptor protein tyrosine kinase activity
GO:0005524 ATP binding
GO:0005634 nucleus
GO:0005737 cytoplasm
GO:0005813 centrosome
GO:0005829 cytosol
GO:0007283 spermatogenesis
GO:0008022 protein C-terminus binding
GO:0019901 protein kinase binding
GO:0030027 lamellipodium
GO:0030036 actin cytoskeleton organization
GO:0031410 cytoplasmic vesicle
GO:0031953 negative regulation of protein autophosphorylation
GO:0032880 regulation of protein localization
GO:0032956 regulation of actin cytoskeleton organization
GO:0042326 negative regulation of phosphorylation
GO:0046872 metal ion binding
GO:0048471 perinuclear region of cytoplasm
GO:0051496 positive regulation of stress fiber assembly
GO:0051650 establishment of vesicle localization
GO:0071901 negative regulation of protein serine/threonine kinase activity
GO:0090521 glomerular visceral epithelial cell migration
GO:0106310 protein serine kinase activity
GO:0106311 protein threonine kinase activity
GO:1900026 positive regulation of substrate adhesion-dependent cell spreading
GO:1900182 positive regulation of protein localization to nucleus
GO:1902018 negative regulation of cilium assembly

Subcellular Location

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Subcellular Location
Cell projection
Cytoplasm

Domains

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DomainNameCategoryType
IPR000719 Protein kinase domainDomainDomain
IPR001245 Serine-threonine/tyrosine-protein kinase, catalytic domainDomainDomain
IPR008266 Tyrosine-protein kinase, active siteSiteActive site
IPR011009 Protein kinase-like domain superfamilyFamilyHomologous superfamily
IPR015782 Dual specificity testis-specific protein kinase 1FamilyFamily
IPR017441 Protein kinase, ATP binding siteSiteBinding site

Diseases

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Drugs

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DrugNameSourceType
DB12010 FostamatinibDrugbanksmall molecule