Entity Details

Primary name NCOA2_HUMAN
Entity type UniProt
Source Source Link

Details

AccessionQ15596
EntryNameNCOA2_HUMAN
FullNameNuclear receptor coactivator 2
TaxID9606
Evidenceevidence at protein level
Length1464
SequenceStatuscomplete
DateCreated2001-02-21
DateModified2021-06-02

Ontological Relatives

GenesNCOA2

GO terms

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GOName
GO:0000122 negative regulation of transcription by RNA polymerase II
GO:0000785 chromatin
GO:0000978 RNA polymerase II cis-regulatory region sequence-specific DNA binding
GO:0001162 RNA polymerase II intronic transcription regulatory region sequence-specific DNA binding
GO:0003682 chromatin binding
GO:0003713 transcription coactivator activity
GO:0005634 nucleus
GO:0005654 nucleoplasm
GO:0005737 cytoplasm
GO:0006355 regulation of transcription, DNA-templated
GO:0010906 regulation of glucose metabolic process
GO:0015721 bile acid and bile salt transport
GO:0016604 nuclear body
GO:0016922 nuclear receptor binding
GO:0017162 aryl hydrocarbon receptor binding
GO:0019216 regulation of lipid metabolic process
GO:0019904 protein domain specific binding
GO:0030374 nuclear receptor coactivator activity
GO:0032570 response to progesterone
GO:0032870 cellular response to hormone stimulus
GO:0032922 circadian regulation of gene expression
GO:0032991 protein-containing complex
GO:0045475 locomotor rhythm
GO:0045944 positive regulation of transcription by RNA polymerase II
GO:0046983 protein dimerization activity
GO:0060765 regulation of androgen receptor signaling pathway
GO:1904017 cellular response to Thyroglobulin triiodothyronine

Subcellular Location

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Subcellular Location
Nucleus

Domains

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DomainNameCategoryType
IPR000014 PAS domainDomainDomain
IPR009110 Nuclear receptor coactivator, interlockingFamilyHomologous superfamily
IPR010011 Nuclear receptor coactivator, DUF1518DomainDomain
IPR011598 Myc-type, basic helix-loop-helix (bHLH) domainDomainDomain
IPR013767 PAS foldDomainDomain
IPR014920 Nuclear receptor coactivator, Ncoa-type, interlockingDomainDomain
IPR014935 Nuclear receptor coactivator, receptor-binding domainDomainDomain
IPR017426 Nuclear receptor coactivatorFamilyFamily
IPR028822 Nuclear receptor coactivator 2FamilyFamily
IPR032565 Domain of unknown function DUF4927DomainDomain
IPR035965 PAS domain superfamilyFamilyHomologous superfamily
IPR036638 Helix-loop-helix DNA-binding domain superfamilyFamilyHomologous superfamily
IPR037077 Nuclear receptor coactivator, Ncoa-type, interlocking domain superfamilyFamilyHomologous superfamily

Diseases

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Drugs

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DrugNameSourceType
DB00255 DiethylstilbestrolDrugbanksmall molecule
DB01645 GenisteinDrugbanksmall molecule
DB02998 MetriboloneDrugbanksmall molecule
DB06871 17-METHYL-17-ALPHA-DIHYDROEQUILENINDrugbanksmall molecule
DB06898 4-(2-amino-1-methyl-1H-imidazo[4,5-b]pyridin-6-yl)phenolDrugbanksmall molecule
DB07080 TO-901317Drugbanksmall molecule
DB07086 4-[(1S,2S,5S)-5-(HYDROXYMETHYL)-8-METHYL-3-OXABICYCLO[3.3.1]NON-7-EN-2-YL]PHENOLDrugbanksmall molecule
DB07087 4-[(1S,2S,5S,9R)-5-(HYDROXYMETHYL)-8,9-DIMETHYL-3-OXABICYCLO[3.3.1]NON-7-EN-2-YL]PHENOLDrugbanksmall molecule
DB07195 4-[(1S,2S,5S)-5-(HYDROXYMETHYL)-6,8,9-TRIMETHYL-3-OXABICYCLO[3.3.1]NON-7-EN-2-YL]PHENOLDrugbanksmall molecule
DB07678 (9ALPHA,13BETA,17BETA)-2-[(1Z)-BUT-1-EN-1-YL]ESTRA-1,3,5(10)-TRIENE-3,17-DIOLDrugbanksmall molecule
DB07707 (9BETA,11ALPHA,13ALPHA,14BETA,17ALPHA)-11-(METHOXYMETHYL)ESTRA-1(10),2,4-TRIENE-3,17-DIOLDrugbanksmall molecule
DB07708 3-CHLORO-2-(4-HYDROXYPHENYL)-2H-INDAZOL-5-OLDrugbanksmall molecule
DB07712 3-ETHYL-2-(4-HYDROXYPHENYL)-2H-INDAZOL-5-OLDrugbanksmall molecule
DB07863 2-chloro-5-nitro-N-phenylbenzamideDrugbanksmall molecule
DB07932 dimethyl (1R,4S)-5,6-bis(4-hydroxyphenyl)-7-oxabicyclo[2.2.1]hepta-2,5-diene-2,3-dicarboxylateDrugbanksmall molecule
DB08047 4-[1-allyl-7-(trifluoromethyl)-1H-indazol-3-yl]benzene-1,3-diolDrugbanksmall molecule
DB08048 4-(6-HYDROXY-1H-INDAZOL-3-YL)BENZENE-1,3-DIOLDrugbanksmall molecule
DB08175 (2E,4E)-11-METHOXY-3,7,11-TRIMETHYLDODECA-2,4-DIENOIC ACIDDrugbanksmall molecule
DB08320 DIETHYL (1R,2S,3R,4S)-5,6-BIS(4-HYDROXYPHENYL)-7-OXABICYCLO[2.2.1]HEPT-5-ENE-2,3-DICARBOXYLATEDrugbanksmall molecule
DB08398 2-Amino-1-methyl-6-phenylimidazo(4,5-b)pyridineDrugbanksmall molecule
DB08402 2-[(2,4-DICHLOROBENZOYL)AMINO]-5-(PYRIMIDIN-2-YLOXY)BENZOIC ACIDDrugbanksmall molecule
DB08595 4-[(1S,2R,5S)-4,4,8-TRIMETHYL-3-OXABICYCLO[3.3.1]NON-7-EN-2-YL]PHENOLDrugbanksmall molecule
DB08601 TributyltinDrugbanksmall molecule
DB08773 2-(4-hydroxyphenyl)benzo[b]thiophen-6-olDrugbanksmall molecule
DB13952 Estradiol acetateDrugbanksmall molecule
DB13953 Estradiol benzoateDrugbanksmall molecule
DB13954 Estradiol cypionateDrugbanksmall molecule
DB13955 Estradiol dienanthateDrugbanksmall molecule
DB13956 Estradiol valerateDrugbanksmall molecule

Interactions

79 interactions

InteractorPartnerSourcesPublicationsLink
NCOA2_HUMANCBP_HUMANBioGRID, HPRD, UniProt11971985 15657427 15987788 9192892 9430642 details
NCOA2_HUMANANDR_HUMANBioGRID, HPRD, IntAct, MINT12588987 12612084 12810069 14593076 14966121 15563469 15684378 9717843 details
NCOA2_HUMANP53_HUMANBioGRID, IntAct20195357 details
NCOA2_HUMANTAF9_HUMANBioGRID, IntAct20195357 details
NCOA2_HUMANESR1_HUMANBioGRID, HPRD, UniProt11014206 11265755 11376110 11937504 12554772 12612084 12630920 12714702 14766010 15657427 16645043 17697320 18499756 19460354 20348541 26487511 9192892 9430642 9774463 details
NCOA2_HUMANPPARA_HUMANBioGRID, IntAct15888456 21775429 details
NCOA2_HUMANPPARD_HUMANBioGRID, IntAct16930961 21775429 details
NCOA2_HUMANRXRA_HUMANBioGRID, DIP, HPRD10748178 11514567 11851396 11981034 12612084 15657427 17947383 21478865 24561505 9430642 details
NCOA2_HUMANRARA_HUMANBioGRID, DIP12503607 12612084 20543827 9192892 9430642 details
NCOA2_HUMANVDR_HUMANBioGRID, DIP, HPRD10748178 11514567 12089346 12612084 12796488 12893883 15919723 21478865 details
NCOA2_HUMANNR5A2_HUMANDIP22504882 details
NCOA2_HUMANTHB_HUMANBioGRID, HPRD11435616 11518802 12612084 9920895 details
NCOA2_HUMANBRCA1_HUMANBioGRID11085509 14578343 16860316 details
NCOA2_HUMANANR11_HUMANBioGRID, HPRD15184363 details
NCOA2_HUMANGCR_HUMANBioGRID, HPRD11266503 12151000 28611094 31182584 9590696 9920895 details
NCOA2_HUMANANM1_HUMANBioGRID, HPRD11050077 details
NCOA2_HUMANAHR_HUMANBioGRID, HPRD12024042 15641800 details
NCOA2_HUMANARNT_HUMANBioGRID, HPRD12024042 26350169 details
NCOA2_HUMANHNF4A_HUMANBioGRID, HPRD9812974 details
NCOA2_HUMANNKX21_HUMANBioGRID, HPRD10617585 details
NCOA2_HUMANLIPA4_HUMANBioGRID11931740 details
NCOA2_HUMANLIPA1_HUMANBioGRID, HPRD11931740 details
NCOA2_HUMANERR2_HUMANBioGRID, HPRD10598588 details
NCOA2_HUMANCCNT1_HUMANBioGRID, HPRD11704662 details
NCOA2_HUMANTRXR2_HUMANBioGRID12612084 details
NCOA2_HUMANCARM1_HUMANBioGRID, HPRD10381882 16923966 18511550 details
NCOA2_HUMANFOS_HUMANBioGRID18511550 details
NCOA2_HUMANMEF2C_HUMANBioGRID, HPRD12130539 details
NCOA2_HUMANCCND3_HUMANBioGRID, HPRD12130539 details
NCOA2_HUMANCDK4_HUMANBioGRID, HPRD12130539 details
NCOA2_HUMANEID1_HUMANBioGRID11964378 details
NCOA2_HUMANESR2_HUMANBioGRID11014206 11376110 11500849 12554772 12630920 details
NCOA2_HUMANPPARG_HUMANBioGRID, HPRD10944516 11500849 11877444 15026545 17513608 19596656 23178929 details
NCOA2_HUMANTHA_HUMANBioGRID11117530 11435616 details
NCOA2_HUMANSTAT6_HUMANBioGRID14757047 details
NCOA2_HUMANMAGAB_HUMANBioGRID19828458 20448036 details
NCOA2_HUMANEP300_HUMANBioGRID, HPRD10490106 15731352 20448036 9920895 details
NCOA2_HUMANNR1I2_HUMANBioGRID23160820 details
NCOA2_HUMANPIAS3_HUMANBioGRID, HPRD12208521 details
NCOA2_HUMANPML_HUMANBioGRID23542129 details
NCOA2_HUMANPSB9_HUMANBioGRID, HPRD16957778 details
NCOA2_HUMANH4_HUMANBioGRID14747462 details
NCOA2_HUMANH31T_HUMANBioGRID14747462 details
NCOA2_HUMANETV1_HUMANBioGRID14747462 details
NCOA2_HUMANCOT1_HUMANBioGRID10652338 details
NCOA2_HUMANFLII_HUMANBioGRID14966289 details
NCOA2_HUMANRORA_HUMANHPRD10478845 details
NCOA2_HUMANKINH_HUMANHPRD11986669 details
NCOA2_HUMANKIF5A_HUMANHPRD11986669 details
NCOA2_HUMANGMEB1_HUMANHPRD10692587 details
NCOA2_HUMANSRCAP_HUMANHPRD14500758 details
NCOA2_HUMANKIF5C_HUMANHPRD11986669 details
NCOA2_HUMANDDX5_HUMANHPRD11250900 details
NCOA2_HUMANDLX2_HUMANHPRD11675124 details
NCOA2_HUMANCTNB1_HUMANHPRD, MINT12588987 details
NCOA2_HUMANNR4A1_HUMANHPRD, IntAct12082103 19095693 details
NCOA2_HUMANNCOA1_HUMANBioGRID11971985 18267973 9751728 9774463 details
NCOA2_HUMANNCOA3_HUMANBioGRID11971985 18267973 details
NCOA2_HUMANUSO1_HUMANBioGRID16051665 details
NCOA2_HUMANUBR5_HUMANBioGRID16051665 details
NCOA2_HUMANPYR1_HUMANBioGRID16051665 details
NCOA2_HUMANWDHD1_HUMANBioGRID16051665 details
NCOA2_HUMANC2D1A_HUMANBioGRID16051665 details
NCOA2_HUMANTBK1_HUMANBioGRID16051665 details
NCOA2_HUMANHSP72_HUMANBioGRID16051665 details
NCOA2_HUMANATR_HUMANBioGRID16051665 details
NCOA2_HUMANPRGR_HUMANBioGRID16728408 29202468 details
NCOA2_HUMANKANK2_HUMANBioGRID17476305 details
NCOA2_HUMANNCOA6_HUMANBioGRID12482968 details
NCOA2_HUMANSMG7_HUMANBioGRID29395067 details
NCOA2_HUMANCPSF1_HUMANBioGRID29395067 details
NCOA2_HUMANACTN2_HUMANHPRD15072553 details
NCOA2_HUMANDLX5_HUMANHPRD11675124 details
NCOA2_HUMAN1433F_HUMANHPRD11266503 details
NCOA2_HUMANSUMO1_HUMANHPRD12060666 details
NCOA2_HUMANSMCE1_HUMANHPRD12145209 details
NCOA2_HUMANHIF1A_HUMANHPRD10594042 details
NCOA2_HUMANJUN_HUMANHPRD11477071 details
NCOA2_HUMANZNT9_HUMANHPRD15988012 details