Entity Details

Primary name SMAD5
Entity type gene
Source Source Link

Details

PrimaryID4090
RefseqGeneNG_032037
SymbolSMAD5
NameSMAD family member 5
Chromosome5
Location5q31.1
TaxID9606
Statuslive
SourceGenomegenomic
SourceOriginnatural
CreationDate1998-08-12
ModificationDate2021-06-11

Ontological Relatives

UniProt IDsSMAD5_HUMAN

GO terms

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GOName
GO:0000785 chromatin
GO:0000978 RNA polymerase II cis-regulatory region sequence-specific DNA binding
GO:0000981 DNA-binding transcription factor activity, RNA polymerase II-specific
GO:0001227 DNA-binding transcription repressor activity, RNA polymerase II-specific
GO:0001657 ureteric bud development
GO:0001880 Mullerian duct regression
GO:0002051 osteoblast fate commitment
GO:0003161 cardiac conduction system development
GO:0005634 nucleus
GO:0005654 nucleoplasm
GO:0005737 cytoplasm
GO:0005829 cytosol
GO:0006468 protein phosphorylation
GO:0007165 signal transduction
GO:0007179 transforming growth factor beta receptor signaling pathway
GO:0007281 germ cell development
GO:0009653 anatomical structure morphogenesis
GO:0009880 embryonic pattern specification
GO:0017151 DEAD/H-box RNA helicase binding
GO:0030154 cell differentiation
GO:0030218 erythrocyte differentiation
GO:0030509 BMP signaling pathway
GO:0030514 negative regulation of BMP signaling pathway
GO:0031625 ubiquitin protein ligase binding
GO:0032991 protein-containing complex
GO:0045669 positive regulation of osteoblast differentiation
GO:0045893 positive regulation of transcription, DNA-templated
GO:0046872 metal ion binding
GO:0051216 cartilage development
GO:0060048 cardiac muscle contraction
GO:0060348 bone development
GO:0060395 SMAD protein signal transduction
GO:0070411 I-SMAD binding
GO:0071141 SMAD protein complex
GO:0071144 heteromeric SMAD protein complex
GO:0071407 cellular response to organic cyclic compound
GO:1901522 positive regulation of transcription from RNA polymerase II promoter involved in cellular response to chemical stimulus
GO:1990837 sequence-specific double-stranded DNA binding

Diseases

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Interactions

78 interactions

InteractorPartnerSourcesPublicationsLink
SMAD5SMURF2BioGRID, HPRD, IntAct, MINT15221015 15231748 20484049 28514442 details
SMAD5SMURF1BioGRID, MINT11278251 12857866 15221015 15231748 16516194 17676934 18641638 19914168 20484049 22670624 details
SMAD5CXXC5BioGRID, HPRD, MINT15231748 details
SMAD5SOX7BioGRID, HPRD, MINT15231748 details
SMAD5PTPN12BioGRID, HPRD, MINT15231748 details
SMAD5SF3B1BioGRID, HPRD, MINT15231748 details
SMAD5MTMR10BioGRID, HPRD, MINT15231748 details
SMAD5PNKPBioGRID, HPRD, MINT15231748 details
SMAD5SFPQBioGRID, HPRD, MINT15231748 details
SMAD5SNRPABioGRID, HPRD, MINT15231748 details
SMAD5PSMD11BioGRID, HPRD, MINT15231748 details
SMAD5U2AF2BioGRID, HPRD, MINT15231748 details
SMAD5SOX5BioGRID, HPRD, MINT15231748 details
SMAD5HBG2BioGRID, HPRD, MINT15231748 details
SMAD5RBM4BioGRID, HPRD, MINT15231748 details
SMAD5RYR2BioGRID, HPRD, MINT15231748 details
SMAD5RNF103-CHMP3MINT15231748 details
SMAD5CHMP3BioGRID, HPRD, MINT15231748 details
SMAD5BCAT1BioGRID, HPRD, MINT15231748 details
SMAD5PPIL4BioGRID, HPRD, MINT15231748 details
SMAD5SNRNP70BioGRID, HPRD, MINT15231748 details
SMAD5ANKRD13ABioGRID, MINT15231748 details
SMAD5WWP1BioGRID, HPRD, MINT15221015 15231748 details
SMAD5NEDD4BioGRID, MINT15231748 details
SMAD5SMAD4BioGRID, HPRD, MINT10531362 15231748 16516194 details
SMAD5SMAD1BioGRID, HPRD, MINT15231748 details
SMAD5UBA1BioGRID, MINT21900206 details
SMAD5SF3B3BioGRID, MINT21900206 details
SMAD5POU6F2BioGRID, IntAct32296183 details
SMAD5WBP2BioGRID, IntAct32296183 details
SMAD5KLK6IntAct32814053 details
SMAD5LITAFIntAct32814053 details
SMAD5PLEKHO1BioGRID18641638 details
SMAD5EP300BioGRID16516194 16613856 details
SMAD5SUV39H1BioGRID, HPRD15107829 details
SMAD5COPS5BioGRID17133595 details
SMAD5HGSBioGRID16516194 details
SMAD5ZNF8HPRD12370310 details
SMAD5FLNAHPRD11278410 details
SMAD5ZEB2HPRD10400677 12714599 details
SMAD5HOXA13HPRD16087734 details
SMAD5MBD1HPRD15231748 details
SMAD5RUNX2BioGRID, Molecular Connections10531362 22966907 details
SMAD5DDX5DIP18548003 details
SMAD5TOB1BioGRID, HPRD11163184 details
SMAD5RUNX1BioGRID10531362 details
SMAD5RUNX3BioGRID10531362 details
SMAD5ACVR1BioGRID, HPRD10583507 10652350 9748228 details
SMAD5HMGA2BioGRID18425117 details
SMAD5SUV39H2BioGRID, HPRD15107829 details
SMAD5KAT2ABioGRID15009097 details
SMAD5SKIBioGRID14699069 details
SMAD5HDAC1BioGRID14699069 details
SMAD5STUB1BioGRID21454478 details
SMAD5MEN1BioGRID, HPRD12649288 details
SMAD5CDK8BioGRID19914168 details
SMAD5YAP1BioGRID19914168 details
SMAD5SMAD6BioGRID12857866 details
SMAD5PAX6BioGRID17251190 details
SMAD5BMP6HPRD10504300 details
SMAD5GDF6HPRD15246821 details
SMAD5IPPKBioGRID, IntAct28514442 details
SMAD5LSRBioGRID, IntAct28514442 details
SMAD5SSMEM1BioGRID, IntAct28514442 details
SMAD5DROSHADIP18548003 details
SMAD5ENGBioGRID, UniProt31540324 details
SMAD5SMAD2BioGRID18729074 details
SMAD5SMAD3BioGRID18729074 details
SMAD5EPN1BioGRID22939629 details
SMAD5NAA20BioGRID22939629 details
SMAD5HECW2BioGRID24163370 details
SMAD5XPO1BioGRID26673895 details
SMAD5PLEKHA4BioGRID31091453 details
SMAD5TAF12BioGRID27703004 details
SMAD5MED24BioGRID27703004 details
SMAD5MED29BioGRID27703004 details
SMAD5ELAVL1BioGRID19322201 details
SMAD5DDX58BioGRID32513696 details