Entity Details

Primary name MRE11
Entity type gene
Source Source Link

Details

PrimaryID4361
RefseqGeneNG_007261
SymbolMRE11
NameMRE11 homolog, double strand break repair nuclease
Chromosome11
Location11q21
TaxID9606
Statuslive
SourceGenomegenomic
SourceOriginnatural
CreationDate1997-10-10
ModificationDate2021-06-13

Ontological Relatives

UniProt IDsMRE11_HUMAN

GO terms

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GOName
GO:0000014 single-stranded DNA endodeoxyribonuclease activity
GO:0000019 regulation of mitotic recombination
GO:0000723 telomere maintenance
GO:0000724 double-strand break repair via homologous recombination
GO:0000729 DNA double-strand break processing
GO:0000781 chromosome, telomeric region
GO:0003690 double-stranded DNA binding
GO:0004518 nuclease activity
GO:0004520 endodeoxyribonuclease activity
GO:0005634 nucleus
GO:0005654 nucleoplasm
GO:0005657 replication fork
GO:0005737 cytoplasm
GO:0005829 cytosol
GO:0006260 DNA replication
GO:0006281 DNA repair
GO:0006302 double-strand break repair
GO:0006303 double-strand break repair via nonhomologous end joining
GO:0006310 DNA recombination
GO:0006974 cellular response to DNA damage stimulus
GO:0007004 telomere maintenance via telomerase
GO:0007062 sister chromatid cohesion
GO:0007095 mitotic G2 DNA damage checkpoint signaling
GO:0007129 homologous chromosome pairing at meiosis
GO:0007131 reciprocal meiotic recombination
GO:0008022 protein C-terminus binding
GO:0008283 cell population proliferation
GO:0008296 3'-5'-exodeoxyribonuclease activity
GO:0008408 3'-5' exonuclease activity
GO:0008409 5'-3' exonuclease activity
GO:0016032 viral process
GO:0016605 PML body
GO:0030145 manganese ion binding
GO:0030870 Mre11 complex
GO:0031573 mitotic intra-S DNA damage checkpoint signaling
GO:0031860 telomeric 3' overhang formation
GO:0031954 positive regulation of protein autophosphorylation
GO:0032206 positive regulation of telomere maintenance
GO:0032481 positive regulation of type I interferon production
GO:0032508 DNA duplex unwinding
GO:0033674 positive regulation of kinase activity
GO:0035861 site of double-strand break
GO:0042138 meiotic DNA double-strand break formation
GO:0042802 identical protein binding
GO:0043066 negative regulation of apoptotic process
GO:0045296 cadherin binding
GO:0097552 mitochondrial double-strand break repair via homologous recombination
GO:0110025 DNA strand resection involved in replication fork processing
GO:1901796 regulation of signal transduction by p53 class mediator

Diseases

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Interactions

194 interactions

InteractorPartnerSourcesPublicationsLink
MRE11NEK1BioGRID, HPRD, IntAct14690447 details
MRE11NBNBioGRID, DIP, HPRD, MINT, UniProt10426999 10783165 11062235 11238951 12419185 12447395 12607003 12679336 12750284 12861053 15734743 15758953 17500065 17612497 18458108 19244116 19270065 21884979 22078559 22231403 22464731 22939629 22941933 23530059 24413181 24981860 26455393 28363998 28369484 30179224 30440001 9705271 details
MRE11MDC1BioGRID, MINT, UniProt12607003 12607005 14519663 18583988 29656893 30179224 details
MRE11FANCD2BioGRID, HPRD, MINT12447395 19609304 31180492 details
MRE11RBBP8BioGRID, DIP, MINT21052091 22231403 25349192 25558984 26387952 26807646 27561354 31636387 details
MRE11HTTIntAct17500595 details
MRE11MAPK8IP2BioGRID, IntAct25814554 details
MRE11MRE11BioGRID, DIP15734743 22078559 22231403 details
MRE11BRCA1BioGRID, UniProt10426999 10783165 11353843 11504724 16391231 17349954 23530059 24413181 25184681 29656893 details
MRE11XRCC6BioGRID, HPRD10508516 26344197 30585729 details
MRE11ATMBioGRID, HPRD10608806 10783165 15758953 details
MRE11ATRBioGRID10608806 details
MRE11PRKDCBioGRID10608806 details
MRE11LIG1BioGRID, HPRD8530104 details
MRE11RECQL5BioGRID19270065 details
MRE11SUMO2BioGRID19394292 32786267 details
MRE11BRIP1BioGRID16391231 23530059 details
MRE11SPOPBioGRID28805822 details
MRE11DYNLL1BioGRID30464262 details
MRE11CDK2BioGRID22231403 details
MRE11SUMO1BioGRID32786267 details
MRE11H2AXBioGRID, DIP, HPRD, IntAct, MINT, UniProt12419185 15201865 16377563 18583988 19234442 22157895 31501894 details
MRE11CCNE1BioGRID, HPRD, UniProt12607005 details
MRE11RAD50BioGRID, DIP, HPRD, IntAct, MINT, UniProt10508516 10783165 10888888 11062235 11504724 12607003 12750284 15734743 16163361 16391231 17500065 17694070 19197236 19270065 22939629 23530059 24413181 24651726 24981860 26215093 26344197 26455393 27173435 28363998 28369484 30179224 30733337 31501894 8756642 9705271 unassigned1312 details
MRE11ATRXBioGRID, UniProt23329831 24651726 27171262 details
MRE11RAD17MINT24534091 details
MRE11CFAP161BioGRID, IntAct27173435 unassigned1312 details
MRE11TERF2BioGRID, DIP10888888 18212065 19287395 22939629 details
MRE11H3-4BioGRID, IntAct25823024 30021884 details
MRE11BLMBioGRID, IntAct10783165 28506294 29523790 details
MRE11MLH1BioGRID10783165 details
MRE11MSH2BioGRID10783165 details
MRE11MSH6BioGRID10783165 details
MRE11RFC1BioGRID10783165 details
MRE11TERF2IPBioGRID15100233 15383534 22939629 details
MRE11DDX1BioGRID18710941 22863883 details
MRE11ATF2BioGRID15916964 details
MRE11PRMT1BioGRID18285453 details
MRE11NLRP2BioGRID18285453 28345663 details
MRE11PAXIP1BioGRID17500065 details
MRE11DCLRE1BBioGRID18469862 details
MRE11KAT5BioGRID20070254 details
MRE11EP300BioGRID, HPRD16051665 details
MRE11BARD1BioGRID16391231 details
MRE11SKP2BioGRID22464731 details
MRE11MDM2BioGRID15734743 details
MRE11DCLRE1CBioGRID, HPRD15456891 31900314 details
MRE11TRRAPBioGRID23318449 details
MRE11RNF8BioGRID23115235 details
MRE11RPA1BioGRID18936170 24332808 30179224 details
MRE11MDM4BioGRID24608433 details
MRE11SLX4BioGRID25533185 details
MRE11USP4BioGRID26455393 details
MRE11SPTA1BioGRID16889989 details
MRE11HDAC6BioGRID24882211 details
MRE11TXNIPBioGRID27437069 details
MRE11MCM9BioGRID26215093 details
MRE11BIRC2BioGRID28363998 details
MRE11RNF169BioGRID30104380 details
MRE11USP7BioGRID30179224 details
MRE11RECQL4BioGRID29229926 details
MRE11TP53BioGRID15806145 24981860 details
MRE11TRIM29BioGRID26095369 details
MRE11ZNF365BioGRID23966166 details
MRE11PPARGBioGRID30699358 details
MRE11UBQLN4BioGRID30612738 details
MRE11CCNA2BioGRID22231403 details
MRE11PELI1BioGRID30952868 details
MRE11PYHIN1BioGRID25665578 details
MRE11NUPR1BioGRID32780723 details
MRE11TOP2ABioGRID31967940 details
MRE11ERCC6BioGRID31501894 details
MRE11USP11BioGRID, IntAct19615732 details
MRE11PARP1MINT19629035 details
MRE11SNW1BioGRID, MINT20467437 details
MRE11CDC5LBioGRID, MINT20467437 details
MRE11APEX1MINT20808282 details
MRE11ILF2BioGRID, MINT20808282 22863883 details
MRE11SIRT1UniProt17612497 details
MRE11DAXXUniProt24651726 details
MRE11AIM2BioGRID, IntAct25665578 details
MRE11FOXP1BioGRID, MINT25609649 details
MRE11GLI1BioGRID, MINT25609649 details
MRE11JUNMINT25609649 details
MRE11OFD1BioGRID, IntAct26638075 details
MRE11ODF2BioGRID, IntAct26638075 details
MRE11CEP43BioGRID, IntAct26638075 details
MRE11ASH2LUniProt17500065 details
MRE11CELA2BBioGRID, IntAct26186194 28514442 details
MRE11BMP1BioGRID, IntAct28514442 details
MRE11FAM219ABioGRID, IntAct26186194 28514442 details
MRE11SCG3BioGRID, IntAct28514442 details
MRE11RRM2BDIP19015526 details
MRE11EXD2BioGRID, DIP26807646 details
MRE11ANGMINT28777577 details
MRE11TP53BP1BioGRID, UniProt29656893 details
MRE11MKI67BioGRID, IntAct26949251 details
MRE11ESR1BioGRID, IntAct31527615 details
MRE11HMGB1BioGRID, UniProt29721183 details
MRE11BRD1BioGRID, MINT24981860 details
MRE11TDRD7BioGRID, MINT24981860 details
MRE11UBCBioGRID16196087 details
MRE11SIRT7BioGRID22586326 details
MRE11TMPOBioGRID22939629 details
MRE11PAN2BioGRID23398456 details
MRE11LMNABioGRID22412018 details
MRE11ABCF1BioGRID22863883 details
MRE11RTRAFBioGRID22863883 details
MRE11RTCBBioGRID22863883 details
MRE11NELFBBioGRID22863883 details
MRE11YBX3BioGRID22863883 details
MRE11DHX9BioGRID22863883 details
MRE11EIF2B2BioGRID22863883 details
MRE11EIF2B3BioGRID22863883 details
MRE11FLIIBioGRID22863883 details
MRE11HNRNPA2B1BioGRID22863883 details
MRE11HNRNPMBioGRID22863883 details
MRE11HNRNPUBioGRID22863883 details
MRE11IGF2BP3BioGRID22863883 details
MRE11LRRFIP1BioGRID22863883 details
MRE11MAP7BioGRID22863883 details
MRE11NMT1BioGRID22863883 details
MRE11QARS1BioGRID22863883 details
MRE11RFC4BioGRID22863883 details
MRE11RPL26L1BioGRID22863883 details
MRE11RPL27BioGRID22863883 details
MRE11RPA2BioGRID24332808 details
MRE11RPA3BioGRID24332808 details
MRE11CIAO1BioGRID23891004 details
MRE11HUWE1BioGRID25147182 details
MRE11CUL7BioGRID24711643 details
MRE11OBSL1BioGRID24711643 details
MRE11EEDBioGRID24457600 details
MRE11FBXW11BioGRID25515538 details
MRE11AIDABioGRID26344197 details
MRE11CHAMP1BioGRID26344197 details
MRE11DRC1BioGRID26344197 details
MRE11FEN1BioGRID26344197 details
MRE11GCC2BioGRID26344197 details
MRE11HOOK3BioGRID26344197 details
MRE11SMARCC1BioGRID26344197 details
MRE11SMARCC2BioGRID26344197 details
MRE11TACC3BioGRID26344197 details
MRE11TPRBioGRID26344197 details
MRE11NTRK1BioGRID25921289 details
MRE11H3C6BioGRID26527279 details
MRE11AK1BioGRID26496610 details
MRE11RAB32BioGRID26496610 details
MRE11TINF2BioGRID26496610 details
MRE11SENP3BioGRID26511642 details
MRE11PCGF1BioGRID26687479 details
MRE11NANOGBioGRID26687479 details
MRE11POU5F1BioGRID26687479 details
MRE11NFATC2BioGRID27637333 details
MRE11CDH1BioGRID25468996 details
MRE11RGS20BioGRID28514442 details
MRE11UBE2ABioGRID28031328 details
MRE11UHRF2BioGRID27114453 details
MRE11EGLN3BioGRID26972000 details
MRE11PTCH1BioGRID26885983 details
MRE11EFTUD2BioGRID28515276 details
MRE11CHD3BioGRID28977666 details
MRE11CHD4BioGRID28977666 details
MRE11ESR2BioGRID29509190 details
MRE11LARP7BioGRID29845934 details
MRE11RNF123BioGRID29676528 details
MRE11RBBP4BioGRID30179224 details
MRE11SEMG2BioGRID30179224 details
MRE11HAT1BioGRID30179224 details
MRE11EZH2BioGRID27634302 details
MRE11FBXW7BioGRID29346117 details
MRE11MYCBioGRID29467282 details
MRE11H4C1BioGRID27248496 30804502 details
MRE11H2BC3BioGRID27248496 details
MRE11TPT1BioGRID28846114 details
MRE11USP14BioGRID30425250 details
MRE11NR2C2BioGRID30463901 details
MRE11UBQLN2BioGRID30442662 details
MRE11HDAC2BioGRID30737378 details
MRE11GBF1BioGRID31519766 details
MRE11DUSP10BioGRID28675297 details
MRE11BIRC3BioGRID30948266 details
MRE11STAU1BioGRID30948266 details
MRE11TRIM28BioGRID29955894 details
MRE11PLEKHA4BioGRID31091453 details
MRE11PINK1BioGRID31300519 details
MRE11PRC1BioGRID31586073 details
MRE11BRPF3BioGRID31753913 details
MRE11TRIM66BioGRID31753913 details
MRE11SEC62BioGRID32788342 details
MRE11NDNBioGRID32529326 details
MRE11ZNF263BioGRID32051553 details
MRE11BRD4BioGRID32416067 details
MRE11UFL1BioGRID32807901 details