Entity Details

Primary name PAK1
Entity type gene
Source Source Link

Details

PrimaryID5058
RefseqGeneNG_029900
SymbolPAK1
Namep21 (RAC1) activated kinase 1
Chromosome11
Location11q13.5-q14.1
TaxID9606
Statuslive
SourceGenomegenomic
SourceOriginnatural
CreationDate1998-05-28
ModificationDate2021-06-11

Ontological Relatives

UniProt IDsPAK1_HUMAN

GO terms

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GOName
GO:0001666 response to hypoxia
GO:0001726 ruffle
GO:0001934 positive regulation of protein phosphorylation
GO:0002223 stimulatory C-type lectin receptor signaling pathway
GO:0004672 protein kinase activity
GO:0004674 protein serine/threonine kinase activity
GO:0005518 collagen binding
GO:0005524 ATP binding
GO:0005654 nucleoplasm
GO:0005694 chromosome
GO:0005737 cytoplasm
GO:0005829 cytosol
GO:0005884 actin filament
GO:0005886 plasma membrane
GO:0005911 cell-cell junction
GO:0005925 focal adhesion
GO:0006338 chromatin remodeling
GO:0006468 protein phosphorylation
GO:0006887 exocytosis
GO:0006915 apoptotic process
GO:0006974 cellular response to DNA damage stimulus
GO:0008284 positive regulation of cell population proliferation
GO:0010763 positive regulation of fibroblast migration
GO:0014704 intercalated disc
GO:0016310 phosphorylation
GO:0016477 cell migration
GO:0019901 protein kinase binding
GO:0021549 cerebellum development
GO:0030010 establishment of cell polarity
GO:0030018 Z disc
GO:0030027 lamellipodium
GO:0030335 positive regulation of cell migration
GO:0030424 axon
GO:0030425 dendrite
GO:0031098 stress-activated protein kinase signaling cascade
GO:0031116 positive regulation of microtubule polymerization
GO:0031295 T cell costimulation
GO:0031532 actin cytoskeleton reorganization
GO:0031965 nuclear membrane
GO:0032147 activation of protein kinase activity
GO:0032587 ruffle membrane
GO:0032869 cellular response to insulin stimulus
GO:0032991 protein-containing complex
GO:0033138 positive regulation of peptidyl-serine phosphorylation
GO:0033148 positive regulation of intracellular estrogen receptor signaling pathway
GO:0038095 Fc-epsilon receptor signaling pathway
GO:0038096 Fc-gamma receptor signaling pathway involved in phagocytosis
GO:0042060 wound healing
GO:0042802 identical protein binding
GO:0043015 gamma-tubulin binding
GO:0043507 positive regulation of JUN kinase activity
GO:0045773 positive regulation of axon extension
GO:0046628 positive regulation of insulin receptor signaling pathway
GO:0046777 protein autophosphorylation
GO:0048012 hepatocyte growth factor receptor signaling pathway
GO:0048013 ephrin receptor signaling pathway
GO:0048754 branching morphogenesis of an epithelial tube
GO:0048812 neuron projection morphogenesis
GO:0050770 regulation of axonogenesis
GO:0050852 T cell receptor signaling pathway
GO:0051496 positive regulation of stress fiber assembly
GO:0060244 negative regulation of cell proliferation involved in contact inhibition
GO:0061052 negative regulation of cell growth involved in cardiac muscle cell development
GO:0090063 positive regulation of microtubule nucleation
GO:0090314 positive regulation of protein targeting to membrane
GO:0106310 protein serine kinase activity
GO:0106311 protein threonine kinase activity
GO:1904707 positive regulation of vascular associated smooth muscle cell proliferation
GO:1904754 positive regulation of vascular associated smooth muscle cell migration

Diseases

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Interactions

237 interactions

InteractorPartnerSourcesPublicationsLink
PAK1CDC42BioGRID, DIP, HPRD, IntAct, mbinfo, MINT10360579 10684602 10802735 11157984 12606577 12650940 12879077 15548653 16678097 18057010 18426980 19596003 20936779 21029865 21048135 21167153 23175184 23455922 24276241 25150978 31478661 7744004 8107774 9535855 9705280 unassigned1271 details
PAK1CDK11BHPRD, IntAct, MINT12624090 16413544 details
PAK1RAC1BioGRID, DIP, HPIDb, HPRD, InnateDB, IntAct, MINT, UniProt10706722 10802735 11030651 11130076 11134022 11950930 12650940 12879077 15075243 15143066 15212766 15548653 15673687 15688026 16002993 16492808 16551621 16678097 17245428 17389360 18426980 19270716 19277120 19327867 19596003 19693014 19732720 19961560 20810653 20936779 21029865 21167153 21454543 21474670 22117219 22581261 24056087 24172987 24625804 24792722 25150978 25468898 25819133 25843002 26175416 29615491 7744004 8107774 9535855 details
PAK1RHOUBioGRID, HPRD, IntAct, mbinfo, MINT14521508 15350535 15556869 18086875 26598620 details
PAK1ARHGEF7BioGRID, HPRD, IntAct, MINT10330411 11157752 16101281 16407834 16492808 16628223 20936779 23455922 26264872 28514442 29997244 31980649 32203420 32814053 details
PAK1RAF1BioGRID, HPRD, MINT10205168 11733498 12551923 17097642 9234708 9823899 details
PAK1CTTNMINT18344974 details
PAK1DYRK1BBioGRID, IntAct20936779 details
PAK1HSP90AA1BioGRID, IntAct20936779 details
PAK1ZNF823BioGRID, IntAct20936779 details
PAK1PAK1BioGRID, DIP, HPRD, IntAct10805734 10975528 11278486 11382770 11804587 16204230 16278681 17389360 18586681 20936779 22153498 31980649 9032240 details
PAK1MYNNBioGRID, IntAct20936779 details
PAK1YWHAGBioGRID, HPRD, IntAct15324660 20936779 details
PAK1YWHAZBioGRID, IntAct20936779 details
PAK1ZC3H7ABioGRID, IntAct20936779 details
PAK1ZBTB18BioGRID, IntAct20936779 details
PAK1ZNF418BioGRID, IntAct20936779 details
PAK1CPLANE1BioGRID, IntAct20936779 details
PAK1ZNF83BioGRID, IntAct20936779 details
PAK1DYNLL1BioGRID, DIP, HPRD, IntAct15193260 17389360 21988832 32814053 details
PAK1DYNLL2BioGRID, IntAct21988832 details
PAK1ARHGEF6BioGRID, HPRD, IntAct, MINT15688026 21900206 23455922 28514442 31980649 32203420 9659915 details
PAK1TGM2BioGRID, MINT21900206 details
PAK1NCK2BioGRID, HPRD, IntAct10026169 11557983 23455922 25416956 26186194 28514442 30886144 31515488 31980649 32296183 details
PAK1LIMK1BioGRID, HPRD, mbinfo10559936 10652353 11340065 details
PAK1RHOJBioGRID, HPRD, IntAct, mbinfo10967094 14521508 28514442 32814053 details
PAK1AKT1BioGRID, HPRD, IntAct12138087 14749719 23397142 24886428 details
PAK1EGFRBioGRID, HPRD, IntAct12522133 24658140 25402006 31980649 details
PAK1PCBP1DIP17389360 details
PAK1HNRNPABDIP17389360 details
PAK1RPL27ADIP17389360 details
PAK1EIF3EDIP17389360 details
PAK1PGM1DIP17389360 details
PAK1RPL7ADIP17389360 details
PAK1SRSF2DIP17389360 details
PAK1TBCBDIP17389360 details
PAK1SRSF5DIP17389360 details
PAK1FLNADIP, HPRD12198493 17389360 details
PAK1RIT1IntAct29734338 details
PAK1TSACCIntAct32814053 details
PAK1RFFLIntAct32814053 details
PAK1ZHX1-C8orf76IntAct32814053 details
PAK1SPSB1IntAct32814053 details
PAK1SEMA4GIntAct32814053 details
PAK1TEX12IntAct32814053 details
PAK1ZNF444IntAct32814053 details
PAK1TTC12IntAct32814053 details
PAK1C11orf54IntAct32814053 details
PAK1KLHL20IntAct32814053 details
PAK1PNKDIntAct32814053 details
PAK1SYNCRIPIntAct32814053 details
PAK1NOD1IntAct32814053 details
PAK1TIMM17BIntAct32814053 details
PAK1STX11IntAct32814053 details
PAK1TCAPIntAct32814053 details
PAK1MAPK11IntAct32814053 details
PAK1OTX2IntAct32814053 details
PAK1LASP1IntAct32814053 details
PAK1GRB10IntAct32814053 details
PAK1ADD1IntAct32814053 details
PAK1ACP2IntAct32814053 details
PAK1FAAP20IntAct32814053 details
PAK1TCP10LIntAct32814053 details
PAK1ARHGEF2BioGRID, HPRD14970201 details
PAK1ARPC1BBioGRID, HPRD14749719 details
PAK1CDK11ABioGRID12624090 details
PAK1ABI3BioGRID, HPRD11956071 details
PAK1PLCG1BioGRID, HPRD12085993 details
PAK1PAK1IP1BioGRID, HPRD11371639 details
PAK1CDK5BioGRID, HPRD11604394 details
PAK1HGSBioGRID, HPRD11397816 details
PAK1NCK1BioGRID, HPRD10026169 10330411 10372803 11157752 11278241 11557983 8824201 9851874 details
PAK1MYLKBioGRID, HPRD10092231 details
PAK1BAIAP2BioGRID11130076 details
PAK1BMXBioGRID, HPRD11382770 details
PAK1H4C1BioGRID, HPRD15864311 details
PAK1ELF3BioGRID17491012 details
PAK1MAP3K1BioGRID12228228 details
PAK1MYO6BioGRID9852149 details
PAK1TGFBR1BioGRID, HPRD15761153 details
PAK1TGFBR2BioGRID, HPRD15761153 details
PAK1APPBioGRID21832049 details
PAK1CHORDC1BioGRID19910486 details
PAK1ESR1BioGRID, HPRD12374744 16452229 details
PAK1BADBioGRID, HPRD10611223 15784622 15849194 16413544 19667065 details
PAK1H3C1BioGRID12151336 details
PAK1BRSK1BioGRID22669945 details
PAK1PPM1ABioGRID18586681 details
PAK1PPP2CABioGRID18586681 details
PAK1PPP1CABioGRID18586681 details
PAK1HACE1BioGRID29362425 details
PAK1GRB2BioGRID, HPRD12522133 details
PAK1OXSR1HPRD14707132 details
PAK1GIT1BioGRID, IntAct, MINT16628223 23455922 25852190 31980649 details
PAK1GIT2BioGRID, HPRD, IntAct, MINT11157752 16628223 25852190 31980649 details
PAK1ATG5IntAct17353931 details
PAK1IKBKEIntAct17353931 details
PAK1SH3KBP1BioGRID, MINT16407834 details
PAK1PLK1MINT20869364 details
PAK1NF2HPRD, IntAct11719502 14580336 21481793 details
PAK1RAC2mbinfo14521508 details
PAK1RAC3mbinfo14521508 details
PAK1RHOQmbinfo14521508 details
PAK1CIB1mbinfo16061695 details
PAK1PYCARDBioGRID, IntAct25402006 details
PAK1PXNBioGRID, HPRD, IntAct10330411 31980649 details
PAK1ERBB2BioGRID, HPRD9774445 details
PAK1PKLRBioGRID12006652 details
PAK1GNB1BioGRID12887923 details
PAK1RELABioGRID26036343 details
PAK1MAPK14BioGRID18586681 details
PAK1WDR26BioGRID27835684 details
PAK1ARHGDIABioGRID27835684 details
PAK1MAP2K1HPRD9351825 details
PAK1CDK5R1HPRD11604394 details
PAK1PDPK1HPRD10995762 details
PAK1FOXL2HPRD12560069 details
PAK1PPM1FHPRD11864573 details
PAK1CSNK2A1HPRD10938077 details
PAK1CSNK2A2HPRD10938077 details
PAK1MAPK1HPRD15542607 details
PAK1ACVR1HPRD15761153 details
PAK1BMPR1BHPRD15761153 details
PAK1SMAD1HPRD15761153 details
PAK1SMAD2HPRD15761153 details
PAK1SMAD4HPRD15761153 details
PAK1SMURF1HPRD15761153 details
PAK1SYN1HPRD12237306 details
PAK1DSCAMHPRD15169762 details
PAK1COL1A1HPRD10772928 details
PAK1PRKCDHPRD16033904 details
PAK1ACTA1HPRD9298982 details
PAK1MBPHPRD14579272 details
PAK1NCF1HPRD12855698 details
PAK1FRS2HPRD12154000 details
PAK1SORBS2HPRD15784622 details
PAK1SHC1HPRD15688026 details
PAK1FOXO1HPRD10358014 12560069 details
PAK1CASP1HPRD15561713 details
PAK1SNW1BioGRID, MINT20467437 details
PAK1SRGAP2UniProt20810653 details
PAK1PAK2BioGRID, IntAct23455922 31980649 details
PAK1FBXO28BioGRID, IntAct23455922 28514442 details
PAK1LRRK2IntAct21454543 details
PAK1H2AXBioGRID, IntAct25852190 details
PAK1CAV1HPIDb24625804 details
PAK1TNFRSF10BIntAct25843002 details
PAK1TNFSF10IntAct25843002 details
PAK1PIK3CBIntAct25843002 details
PAK1PRKCZIntAct23175184 unassigned1271 details
PAK1RPS6KB1IntAct23175184 unassigned1271 details
PAK1ICAM1BioGRID, IntAct28514442 details
PAK1SLC25A41BioGRID, IntAct26186194 28514442 details
PAK1FGBBioGRID, IntAct28514442 details
PAK1SOX2BioGRID, IntAct28514442 details
PAK1FSD1BioGRID, IntAct28514442 details
PAK1TAS2R41BioGRID, IntAct26186194 28514442 details
PAK1SETXBioGRID, IntAct28514442 details
PAK1OR2K2BioGRID, IntAct28514442 details
PAK1LPXNBioGRID, IntAct28514442 details
PAK1RIOK1BioGRID, IntAct31980649 details
PAK1SLC25A6BioGRID, IntAct31980649 details
PAK1SLC25A4BioGRID, IntAct31980649 details
PAK1HSPA6BioGRID, IntAct31980649 details
PAK1CADBioGRID, IntAct31980649 details
PAK1DNAJA1BioGRID, IntAct31980649 details
PAK1ARL1BioGRID, IntAct31980649 details
PAK1SLC25A1BioGRID, IntAct31980649 details
PAK1TMEM33BioGRID, IntAct31980649 details
PAK1PRPS1BioGRID, IntAct31980649 details
PAK1TUBA1BBioGRID, IntAct31980649 details
PAK1TUBB4BBioGRID, IntAct31980649 details
PAK1SLC25A3BioGRID, IntAct31980649 details
PAK1SLC7A5BioGRID, IntAct31980649 details
PAK1AKAP12BioGRID, IntAct31980649 details
PAK1SLC25A11BioGRID, IntAct31980649 details
PAK1ASPHBioGRID, IntAct31980649 details
PAK1SCRIBBioGRID, IntAct31980649 details
PAK1RCN2BioGRID, IntAct31980649 details
PAK1PRPSAP1BioGRID, IntAct31980649 details
PAK1DDB1BioGRID, IntAct31980649 details
PAK1DBN1BioGRID, IntAct31980649 details
PAK1TUBB8BioGRID, IntAct31980649 details
PAK1HSD17B12BioGRID, IntAct31980649 details
PAK1TUBA1ABioGRID, IntAct31980649 details
PAK1TUBA3EBioGRID, IntAct31980649 details
PAK1SLC39A7BioGRID, IntAct31980649 details
PAK1GCN1BioGRID, IntAct31980649 details
PAK1PGAM5BioGRID, IntAct31980649 details
PAK1MMS19BioGRID, IntAct31980649 details
PAK1TUBA1CBioGRID, IntAct31980649 details
PAK1TUBB6BioGRID, IntAct31980649 details
PAK1SLC25A22BioGRID, IntAct31980649 details
PAK1PDP1BioGRID, IntAct31980649 details
PAK1ACSL5BioGRID, IntAct31980649 details
PAK1RUVBL2BioGRID, IntAct31980649 details
PAK1HIGD1ABioGRID, IntAct31980649 details
PAK1HIGD1CBioGRID, IntAct31980649 details
PAK1RUVBL1BioGRID, IntAct31980649 details
PAK1IVNS1ABPBioGRID, IntAct31980649 details
PAK1XPO1BioGRID, IntAct31980649 details
PAK1PRPSAP2BioGRID, IntAct31980649 details
PAK1DPM1BioGRID, IntAct31980649 details
PAK1DNAJA2BioGRID, IntAct31980649 details
PAK1UBR5BioGRID, IntAct31980649 details
PAK1AIFM1BioGRID, IntAct31980649 details
PAK1HSPB1BioGRID, IntAct31980649 details
PAK1SLC25A5BioGRID, IntAct31980649 details
PAK1TUBBBioGRID, IntAct31980649 details
PAK1PSAPBioGRID, IntAct31980649 details
PAK1SLC3A2BioGRID, IntAct31980649 details
PAK1CYC1BioGRID, IntAct31980649 details
PAK1MGST1BioGRID, IntAct31980649 details
PAK1HSPA8BioGRID, IntAct31980649 details
PAK1PRPS2BioGRID, IntAct31980649 details
PAK1SLC16A3BioGRID, IntAct31980649 details
PAK1HLA-ABioGRID, IntAct31980649 details
PAK1HLA-CBioGRID, IntAct31980649 details
PAK1GSNBioGRID, IntAct31980649 details
PAK1HLA-BBioGRID, IntAct31980649 details
PAK1POLR2BBioGRID, IntAct31980649 details
PAK1CPT1ABioGRID, IntAct31980649 details
PAK1VAT1BioGRID, IntAct31980649 details
PAK1ARPC5LBioGRID, IntAct31980649 details
PAK1TUBB2BBioGRID, IntAct31980649 details
PAK1FANCD2BioGRID, IntAct31980649 details
PAK1TMEM161ABioGRID, IntAct31980649 details
PAK1TECRBioGRID, IntAct31980649 details
PAK1LIMA1BioGRID, IntAct31980649 details
PAK1LYNBioGRID23503679 details
PAK1ILKAPBioGRID26344197 details
PAK1PPATBioGRID26344197 details
PAK1HDAC4BioGRID27684187 details
PAK1PLEKHA4BioGRID31091453 details
PAK1TUBA3CBioGRID31980649 details
PAK1HSPA1ABioGRID, IntAct31980649 details
PAK1HSPA1BIntAct31980649 details