Entity Details

Primary name MA2A1_HUMAN
Entity type UniProt
Source Source Link

Details

AccessionQ16706
EntryNameMA2A1_HUMAN
FullNameAlpha-mannosidase 2
TaxID9606
Evidenceevidence at protein level
Length1144
SequenceStatuscomplete
DateCreated1998-07-15
DateModified2021-06-02

Ontological Relatives

GenesMAN2A1

GO terms

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GOName
GO:0000139 Golgi membrane
GO:0001701 in utero embryonic development
GO:0001889 liver development
GO:0004559 alpha-mannosidase activity
GO:0004572 mannosyl-oligosaccharide 1,3-1,6-alpha-mannosidase activity
GO:0005797 Golgi medial cisterna
GO:0005801 cis-Golgi network
GO:0006013 mannose metabolic process
GO:0006486 protein glycosylation
GO:0006491 N-glycan processing
GO:0006517 protein deglycosylation
GO:0007005 mitochondrion organization
GO:0007033 vacuole organization
GO:0007585 respiratory gaseous exchange by respiratory system
GO:0016020 membrane
GO:0016021 integral component of membrane
GO:0016799 hydrolase activity, hydrolyzing N-glycosyl compounds
GO:0019082 viral protein processing
GO:0030246 carbohydrate binding
GO:0042803 protein homodimerization activity
GO:0046872 metal ion binding
GO:0048286 lung alveolus development
GO:0050769 positive regulation of neurogenesis
GO:0060042 retina morphogenesis in camera-type eye
GO:0070062 extracellular exosome

Subcellular Location

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Subcellular Location
Golgi apparatus membrane

Domains

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DomainNameCategoryType
IPR000602 Glycoside hydrolase family 38, N-terminal domainDomainDomain
IPR011013 Galactose mutarotase-like domain superfamilyFamilyHomologous superfamily
IPR011330 Glycoside hydrolase/deacetylase, beta/alpha-barrelFamilyHomologous superfamily
IPR011682 Glycosyl hydrolase family 38, C-terminalDomainDomain
IPR013780 Glycosyl hydrolase, all-betaFamilyHomologous superfamily
IPR015341 Glycoside hydrolase family 38, central domainDomainDomain
IPR027291 Glycoside hydrolase 38, N-terminal domain superfamilyFamilyHomologous superfamily
IPR028995 Glycoside hydrolase families 57/38, central domain superfamilyFamilyHomologous superfamily
IPR037094 Glycoside hydrolase family 38, central domain superfamilyFamilyHomologous superfamily

Diseases

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Drugs

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DrugNameSourceType
DB02034 TridolgosirDrugbanksmall molecule
DB02318 2-deoxy-2-fluoro-alpha-D-mannosyl fluorideDrugbanksmall molecule
DB02492 GhavamiolDrugbanksmall molecule
DB02742 KifunensineDrugbanksmall molecule
DB03008 5-fluoro-beta-L-gulosyl fluorideDrugbanksmall molecule
DB03414 5-Thio-a/B-D-MannopyranosylamineDrugbanksmall molecule
DB03955 1-deoxymannojirimycinDrugbanksmall molecule
DB06984 (1R,2R,3R,4S,5R)-4-(BENZYLAMINO)-5-(METHYLTHIO)CYCLOPENTANE-1,2,3-TRIOLDrugbanksmall molecule
DB08321 (1S,2S,3R,6R)-4-(hydroxymethyl)-6-(octylamino)cyclohex-4-ene-1,2,3-triolDrugbanksmall molecule

Interactions

2 interactions

InteractorPartnerSourcesPublicationsLink
MA2A1_HUMANSC23B_HUMANBioGRID9472029 details
MA2A1_HUMANTMED9_HUMANBioGRID9472029 details