Entity Details

Primary name AT2B3_HUMAN
Entity type UniProt
Source Source Link

Details

AccessionQ16720
EntryNameAT2B3_HUMAN
FullNamePlasma membrane calcium-transporting ATPase 3
TaxID9606
Evidenceevidence at protein level
Length1220
SequenceStatuscomplete
DateCreated1997-11-01
DateModified2021-06-02

Ontological Relatives

GenesATP2B3

GO terms

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GOName
GO:0005388 P-type calcium transporter activity
GO:0005516 calmodulin binding
GO:0005524 ATP binding
GO:0005886 plasma membrane
GO:0005887 integral component of plasma membrane
GO:0006874 cellular calcium ion homeostasis
GO:0015085 calcium ion transmembrane transporter activity
GO:0019829 ATPase-coupled cation transmembrane transporter activity
GO:0030165 PDZ domain binding
GO:0034220 ion transmembrane transport
GO:0043231 intracellular membrane-bounded organelle
GO:0046872 metal ion binding
GO:0051480 regulation of cytosolic calcium ion concentration
GO:0098793 presynapse
GO:0098978 glutamatergic synapse
GO:0098982 GABA-ergic synapse
GO:1903561 extracellular vesicle
GO:1903779 regulation of cardiac conduction
GO:1905056 P-type calcium transporter activity involved in regulation of presynaptic cytosolic calcium ion concentration
GO:1990034 calcium ion export across plasma membrane

Subcellular Location

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Subcellular Location
Cell junction
Cell membrane

Domains

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DomainNameCategoryType
IPR001757 P-type ATPaseFamilyFamily
IPR004014 Cation-transporting P-type ATPase, N-terminalDomainDomain
IPR006068 Cation-transporting P-type ATPase, C-terminalDomainDomain
IPR006408 P-type ATPase, subfamily IIBFamilyFamily
IPR008250 P-type ATPase, A domain superfamilyFamilyHomologous superfamily
IPR018303 P-type ATPase, phosphorylation sitePTMPTM
IPR022141 Plasma membrane calcium transporting P-type ATPase, C-terminalDomainDomain
IPR023214 HAD superfamilyFamilyHomologous superfamily
IPR023298 P-type ATPase, transmembrane domain superfamilyFamilyHomologous superfamily
IPR023299 P-type ATPase, cytoplasmic domain NFamilyHomologous superfamily
IPR036412 HAD-like superfamilyFamilyHomologous superfamily
IPR044492 P-type ATPase, haloacid dehalogenase domainDomainDomain

Diseases

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Disease IDSourceNameDescription
302500 OMIMSpinocerebellar ataxia, X-linked 1 (SCAX1)Spinocerebellar ataxia is a clinically and genetically heterogeneous group of cerebellar disorders. Patients show progressive incoordination of gait and often poor coordination of hands, speech and eye movements, due to degeneration of the cerebellum with variable involvement of the brainstem and spinal cord. SCAX1 is characterized by hypotonia at birth, delayed motor development, gait ataxia, difficulty standing, dysarthria, and slow eye movements. Brain MRI shows cerebellar ataxia. The disease is caused by variants affecting the gene represented in this entry.

Drugs

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DrugNameSourceType
DB01159 HalothaneDrugbanksmall molecule
DB01189 DesfluraneDrugbanksmall molecule

Interactions

3 interactions