Entity Details

Primary name HCDH_HUMAN
Entity type UniProt
Source Source Link

Details

AccessionQ16836
EntryNameHCDH_HUMAN
FullNameHydroxyacyl-coenzyme A dehydrogenase, mitochondrial
TaxID9606
Evidenceevidence at protein level
Length314
SequenceStatuscomplete
DateCreated1997-11-01
DateModified2021-06-02

Ontological Relatives

GenesHADH

GO terms

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GOName
GO:0003857 3-hydroxyacyl-CoA dehydrogenase activity
GO:0005654 nucleoplasm
GO:0005737 cytoplasm
GO:0005739 mitochondrion
GO:0005759 mitochondrial matrix
GO:0006635 fatty acid beta-oxidation
GO:0016740 transferase activity
GO:0042802 identical protein binding
GO:0050796 regulation of insulin secretion
GO:0070403 NAD+ binding
GO:0120162 positive regulation of cold-induced thermogenesis

Subcellular Location

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Subcellular Location
Mitochondrion matrix

Domains

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DomainNameCategoryType
IPR006108 3-hydroxyacyl-CoA dehydrogenase, C-terminalDomainDomain
IPR006176 3-hydroxyacyl-CoA dehydrogenase, NAD bindingDomainDomain
IPR006180 3-hydroxyacyl-CoA dehydrogenase, conserved siteSiteConserved site
IPR008927 6-phosphogluconate dehydrogenase-like, C-terminal domain superfamilyFamilyHomologous superfamily
IPR013328 6-phosphogluconate dehydrogenase, domain 2FamilyHomologous superfamily
IPR022694 3-hydroxyacyl-CoA dehydrogenaseFamilyFamily
IPR036291 NAD(P)-binding domain superfamilyFamilyHomologous superfamily

Diseases

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Drugs

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DrugNameSourceType
DB00157 NADHDrugbanksmall molecule
DB03059 Acetoacetyl-CoADrugbanksmall molecule
DB03612 3-Hydroxybutyryl-Coenzyme ADrugbanksmall molecule
DB09568 Omega-3-carboxylic acidsDrugbanksmall molecule