Entity Details

Primary name TRXR1_HUMAN
Entity type UniProt
Source Source Link

Details

AccessionQ16881
EntryNameTRXR1_HUMAN
FullNameThioredoxin reductase 1, cytoplasmic
TaxID9606
Evidenceevidence at protein level
Length649
SequenceStatuscomplete
DateCreated1997-11-01
DateModified2021-06-02

Ontological Relatives

GenesTXNRD1

GO terms

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GOName
GO:0001650 fibrillar center
GO:0001707 mesoderm formation
GO:0001887 selenium compound metabolic process
GO:0004791 thioredoxin-disulfide reductase activity
GO:0005654 nucleoplasm
GO:0005737 cytoplasm
GO:0005739 mitochondrion
GO:0005829 cytosol
GO:0007165 signal transduction
GO:0008283 cell population proliferation
GO:0015035 protein-disulfide reductase activity
GO:0015949 nucleobase-containing small molecule interconversion
GO:0019222 regulation of metabolic process
GO:0034599 cellular response to oxidative stress
GO:0045454 cell redox homeostasis
GO:0050660 flavin adenine dinucleotide binding
GO:0070062 extracellular exosome

Subcellular Location

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Subcellular Location
Cytoplasm
Nucleus

Domains

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DomainNameCategoryType
IPR002109 GlutaredoxinDomainDomain
IPR004099 Pyridine nucleotide-disulphide oxidoreductase, dimerisation domainDomainDomain
IPR006338 Thioredoxin/glutathione reductase selenoproteinFamilyFamily
IPR012999 Pyridine nucleotide-disulphide oxidoreductase, class I, active siteSiteActive site
IPR016156 FAD/NAD-linked reductase, dimerisation domain superfamilyFamilyHomologous superfamily
IPR023753 FAD/NAD(P)-binding domainDomainDomain
IPR036188 FAD/NAD(P)-binding domain superfamilyFamilyHomologous superfamily
IPR036249 Thioredoxin-like superfamilyFamilyHomologous superfamily

Diseases

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Drugs

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DrugNameSourceType
DB00126 Ascorbic acidDrugbanksmall molecule
DB01169 Arsenic trioxideDrugbanksmall molecule
DB02338 NADPHDrugbanksmall molecule
DB03147 Flavin adenine dinucleotideDrugbanksmall molecule
DB03566 SpermidineDrugbanksmall molecule
DB04106 FotemustineDrugbanksmall molecule
DB05428 Motexafin gadoliniumDrugbanksmall molecule
DB05448 PX-12Drugbanksmall molecule
DB11127 Selenious acidSwissprotsmall molecule
DB11135 SeleniumSwissprotsmall molecule