Entity Details

Primary name MAPK8
Entity type gene
Source Source Link

Details

PrimaryID5599
RefseqGeneNG_029053
SymbolMAPK8
Namemitogen-activated protein kinase 8
Chromosome10
Location10q11.22
TaxID9606
Statuslive
SourceGenomegenomic
SourceOriginnatural
CreationDate1999-09-08
ModificationDate2021-06-11

Ontological Relatives

UniProt IDsMK08_HUMAN

GO terms

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GOName
GO:0004674 protein serine/threonine kinase activity
GO:0004705 JUN kinase activity
GO:0004707 MAP kinase activity
GO:0005524 ATP binding
GO:0005634 nucleus
GO:0005654 nucleoplasm
GO:0005737 cytoplasm
GO:0005739 mitochondrion
GO:0005829 cytosol
GO:0006302 double-strand break repair
GO:0006468 protein phosphorylation
GO:0006979 response to oxidative stress
GO:0007254 JNK cascade
GO:0007258 JUN phosphorylation
GO:0009411 response to UV
GO:0009612 response to mechanical stimulus
GO:0010628 positive regulation of gene expression
GO:0016241 regulation of macroautophagy
GO:0018105 peptidyl-serine phosphorylation
GO:0018107 peptidyl-threonine phosphorylation
GO:0019899 enzyme binding
GO:0030424 axon
GO:0031281 positive regulation of cyclase activity
GO:0031343 positive regulation of cell killing
GO:0032091 negative regulation of protein binding
GO:0032880 regulation of protein localization
GO:0034198 cellular response to amino acid starvation
GO:0034614 cellular response to reactive oxygen species
GO:0035033 histone deacetylase regulator activity
GO:0035556 intracellular signal transduction
GO:0038095 Fc-epsilon receptor signaling pathway
GO:0042752 regulation of circadian rhythm
GO:0042826 histone deacetylase binding
GO:0043065 positive regulation of apoptotic process
GO:0043066 negative regulation of apoptotic process
GO:0045202 synapse
GO:0048511 rhythmic process
GO:0051090 regulation of DNA-binding transcription factor activity
GO:0051247 positive regulation of protein metabolic process
GO:0051403 stress-activated MAPK cascade
GO:0071222 cellular response to lipopolysaccharide
GO:0071260 cellular response to mechanical stimulus
GO:0071276 cellular response to cadmium ion
GO:0071345 cellular response to cytokine stimulus
GO:0090045 positive regulation of deacetylase activity
GO:0097441 basal dendrite
GO:0106310 protein serine kinase activity
GO:0106311 protein threonine kinase activity
GO:1900740 positive regulation of protein insertion into mitochondrial membrane involved in apoptotic signaling pathway
GO:1902595 regulation of DNA replication origin binding

Diseases

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Interactions

219 interactions

InteractorPartnerSourcesPublicationsLink
MAPK8BCL2BioGRID, HPRD, MINT10567572 12039864 15225643 15733859 details
MAPK8BCL2L1BioGRID, HPRD, IntAct, MINT15733859 22617334 25241761 details
MAPK8JUNBioGRID, DIP, HPRD, IntAct, MINT, UniProt10101227 10393177 10398438 10419510 10464310 10747973 10908726 10962563 10987838 11108663 11278395 11479302 11532856 11907583 12052834 12149229 12185592 12228228 12407442 12832416 12963725 13130464 14517282 14557262 14572659 14612408 14633987 14701799 15143066 15289320 15299005 15302935 15590691 15677475 15749833 15894542 15958389 16007099 16142216 16157600 16166642 16291755 16434970 16533805 16549498 16740711 16824735 16983342 17189706 17363973 17875713 18003900 18429822 18922473 18957422 19270716 19527717 19910486 20133937 20514406 20732415 22110360 22904686 23816567 25098452 7527398 8001819 8137421 8224842 8586671 8621542 8654373 8846788 9032244 9575168 9692890 9774977 9808624 9990010 details
MAPK8MAP2K7BioGRID, HPRD, IntAct10713157 11062067 12821118 13130464 16533805 24975362 25241761 25284480 26364603 9207092 details
MAPK8MAP2K4BioGRID, HPRD, IntAct10713157 11062067 11279118 11707464 12391307 12788955 13130464 15998799 16533805 9162092 9661668 9808624 details
MAPK8ATF2BioGRID, HPRD, IntAct11279118 11566021 11865055 12804775 12874243 12958075 15550563 16533805 17875713 21444723 7535770 7737129 7737130 8654373 9162092 9207092 9399639 9405416 details
MAPK8MAPK8IP1BioGRID, HPRD, IntAct, MINT11700324 12756254 15998799 16343492 16533805 16840345 18286207 28514442 9733513 details
MAPK8MAP3K7BioGRID, HPRD, IntAct11865055 17709393 details
MAPK8CBLBioGRID, MINT11944898 16982329 details
MAPK8CRKBioGRID, HPRD, IntAct, MINT11432831 16982329 25241761 details
MAPK8CAMPBioGRID, IntAct21988832 details
MAPK8GARS1BioGRID, IntAct21988832 details
MAPK8GFPT1BioGRID, IntAct21988832 details
MAPK8MKNK2BioGRID, IntAct21988832 details
MAPK8GUCY1A1BioGRID, IntAct21988832 details
MAPK8HSD17B4BioGRID, IntAct21988832 details
MAPK8RAF1BioGRID, IntAct21988832 details
MAPK8RPLP2BioGRID, IntAct21988832 details
MAPK8RPS6KB1BioGRID, HPRD, IntAct11279232 21988832 23816567 details
MAPK8GANABBioGRID, IntAct21988832 details
MAPK8NKAPD1BioGRID, IntAct21988832 details
MAPK8HIVEP1BioGRID, IntAct21988832 details
MAPK8ID2BioGRID, IntAct21988832 details
MAPK8SSU72BioGRID, IntAct21988832 details
MAPK8SCOCBioGRID, IntAct21988832 details
MAPK8BMPR2BioGRID, MINT21900206 details
MAPK8CCDC88CBioGRID, MINT21900206 details
MAPK8DUSP8BioGRID, IntAct, MINT21900206 26186194 27432908 27880917 28514442 details
MAPK8FAM193BBioGRID, MINT21900206 details
MAPK8HSPA8BioGRID, MINT21900206 details
MAPK8PNRC1BioGRID, MINT21900206 details
MAPK8RBM15BioGRID, MINT21900206 details
MAPK8SCAND1BioGRID, MINT21900206 details
MAPK8ZNF219BioGRID, MINT21900206 details
MAPK8DUSP4BioGRID, HPRD, MINT11387337 16038800 19843478 28675297 details
MAPK8MAP3K1BioGRID, IntAct12228228 14500727 15299005 21152872 25241761 9405400 details
MAPK8GSTP1BioGRID, HPRD, IntAct11279197 12646564 16636664 25241761 26429914 details
MAPK8PXNBioGRID, HPRD, IntAct12853963 23397142 30120307 details
MAPK8EGFRBioGRID, IntAct24658140 25402006 31980649 details
MAPK8HNF4AIntAct15550563 details
MAPK8DUSP10BioGRID, HPRD, IntAct10391943 10597297 16166642 28675297 32296183 details
MAPK8DUSP16BioGRID, HPRD, IntAct11489891 27432908 28675297 32296183 details
MAPK8WDR62BioGRID, IntAct19910486 26186194 28514442 details
MAPK8H2AXBioGRID, DIP17145805 19234442 20512932 details
MAPK8HSF1BioGRID, DIP, HPRD10747973 27043084 details
MAPK8IRS1BioGRID, HPRD10722755 11606564 12351658 12417588 details
MAPK8SPIBBioGRID, HPRD8632909 details
MAPK8SPI1BioGRID8632909 details
MAPK8SH3BP5BioGRID, HPRD12167088 details
MAPK8ELP1BioGRID, HPRD12058026 details
MAPK8JUNDBioGRID, HPRD12052834 16264271 details
MAPK8MAPK8IP3BioGRID, HPRD10523642 10629060 12189133 16141199 details
MAPK8PAX2BioGRID, HPRD11700324 details
MAPK8PRKDCBioGRID, HPRD11749722 details
MAPK8TP53BioGRID, HPRD11108663 11283254 12514174 15538975 18813780 19651615 9393873 9724739 9732264 details
MAPK8RELBioGRID, HPRD8621542 details
MAPK8ETV1BioGRID11551945 details
MAPK8ELK1BioGRID, HPRD17875713 8586671 8654373 8846788 details
MAPK8DUSP1BioGRID, HPRD11278799 28675297 details
MAPK8MYCBioGRID, HPRD10551811 1748630 details
MAPK8PDPK1BioGRID10357815 details
MAPK8NR4A1BioGRID14612408 17023523 details
MAPK8CEBPABioGRID16983342 details
MAPK8CDKN1ABioGRID, HPRD12058028 20102411 details
MAPK8SIRT1BioGRID20027304 details
MAPK8HDAC9BioGRID16611996 details
MAPK8TFCP2BioGRID15857981 details
MAPK8NFE2BioGRID19966288 details
MAPK8PIAS2BioGRID19815509 details
MAPK8ZNF605BioGRID21900206 details
MAPK8STAT3BioGRID, HPRD10446219 10521505 11350938 12576423 12763138 14551213 15979846 9343414 9872331 details
MAPK8NCOA3BioGRID15383283 details
MAPK8FZR1BioGRID20581839 details
MAPK8ITCHBioGRID16446428 details
MAPK8RAD18BioGRID22456510 details
MAPK8MAP3K4BioGRID21152872 26496610 details
MAPK8SP1BioGRID19245816 25398907 details
MAPK8MAPK8BioGRID20194509 23602568 31980649 details
MAPK8MAP2K1BioGRID16533805 details
MAPK8MAP2K2BioGRID16533805 details
MAPK8CTNNB1BioGRID19667122 details
MAPK8CDKN1BBioGRID12963725 details
MAPK8APPBioGRID12917434 21832049 details
MAPK8GORASP2BioGRID11408587 details
MAPK8IRF3BioGRID19153595 details
MAPK8AIMP1BioGRID20510162 details
MAPK8ELK4BioGRID9020136 details
MAPK8BCL2L11BioGRID, HPRD12591950 12818176 details
MAPK8BMFBioGRID, HPRD12591950 details
MAPK8JKAMPBioGRID, HPRD16166642 details
MAPK8MAPKAP1BioGRID15722200 details
MAPK8NFATC4BioGRID17875713 details
MAPK8NFATC3BioGRID17875713 details
MAPK8CASP3BioGRID12821118 details
MAPK8PKMYT1BioGRID19204086 details
MAPK8SERPINB3BioGRID16549498 details
MAPK8SERPINB4BioGRID16549498 details
MAPK8CDKN2ABioGRID16007099 details
MAPK8CDKN2CBioGRID16007099 details
MAPK8WWOXBioGRID, HPRD12514174 18371080 details
MAPK8MAPTBioGRID15228592 9199504 details
MAPK8APLP2BioGRID12917434 details
MAPK8GEMIN5BioGRID17541429 details
MAPK8NFE2L2BioGRID24704364 31945188 details
MAPK8YWHAZBioGRID, HPRD15696159 details
MAPK8EP300BioGRID11278389 details
MAPK8AKT1BioGRID20186153 details
MAPK8MBPBioGRID10978313 details
MAPK8APBB2BioGRID17567906 details
MAPK8METTL3BioGRID33217317 details
MAPK8PIK3R1HPRD, IntAct, MINT16982329 25284480 7642542 details
MAPK8CRKLMINT16982329 details
MAPK8FLNBBioGRID, MINT19270716 details
MAPK8FASBioGRID, IntAct15659383 25241761 details
MAPK8FASLGBioGRID, IntAct15659383 25241761 details
MAPK8RHOABioGRID, IntAct15659383 25241761 details
MAPK8SMAD3BioGRID, HPRD, IntAct10601313 25241761 details
MAPK8BADHPRD, IntAct14967141 23397142 details
MAPK8APBB1DIP19234442 details
MAPK8RPTORBioGRID, DIP22493283 27043084 details
MAPK8TNFRSF10BBioGRID15659383 details
MAPK8FADDBioGRID15659383 details
MAPK8BIDBioGRID15659383 details
MAPK8EZRBioGRID15659383 details
MAPK8ARHGDIABioGRID15659383 details
MAPK8MSNBioGRID15659383 details
MAPK8CASP10BioGRID15659383 details
MAPK8CASP8BioGRID15659383 details
MAPK8TNFRSF1ABioGRID15659383 details
MAPK8PRKD1BioGRID, HPRD11948398 details
MAPK8SPAG9BioGRID, HPRD12391307 details
MAPK8BCAR1BioGRID11432831 details
MAPK8SNCGBioGRID, HPRD12121974 details
MAPK8SNCABioGRID12121974 details
MAPK8JUNBBioGRID, HPRD8917518 9405416 9889198 details
MAPK8MAP3K2BioGRID, HPRD10713157 details
MAPK8HDAC1BioGRID16611996 details
MAPK8NFATC2BioGRID15184502 details
MAPK8KRT8BioGRID, HPRD11781324 11788583 9211903 details
MAPK8MTORBioGRID22493283 details
MAPK8TRAF2BioGRID9692890 details
MAPK8STAB2BioGRID18387958 details
MAPK8DCP1ABioGRID19910486 details
MAPK8RB1BioGRID11566021 details
MAPK8ATF7BioGRID11566021 details
MAPK8VANGL2BioGRID26754771 details
MAPK8MAPK14BioGRID, HPRD15778365 18586681 details
MAPK8BANPBioGRID28617439 details
MAPK8HSP90AA1BioGRID17891170 details
MAPK8PTK2BioGRID16141199 details
MAPK8BAXBioGRID19910452 details
MAPK8BAK1BioGRID19910452 details
MAPK8SH3RF3BioGRID32427938 details
MAPK8RETHPRD16153436 details
MAPK8HRASHPRD11525649 16810318 8137421 details
MAPK8ELK3HPRD11042694 details
MAPK8PPARGHPRD9030579 details
MAPK8TNFSF11HPRD9396779 details
MAPK8EEF2KHPRD12171600 details
MAPK8IL27RAHPRD12734330 details
MAPK8MAPK8IP2HPRD10490659 10756100 details
MAPK8DUSP22HPRD12138158 details
MAPK8JDP2HPRD11602244 12225289 details
MAPK8MAPKBP1HPRD10471813 details
MAPK8COPS2HPRD10585392 details
MAPK8DUSP7HPRD9788880 details
MAPK8MAPK3HPRD15778365 details
MAPK8MAPK1HPRD15778365 details
MAPK8SMAD2HPRD15326485 details
MAPK8HSF4HPRD16581800 details
MAPK8RASSF1HPRD16810318 details
MAPK8SHC1HPRD15688026 details
MAPK8TP73HPRD15483136 details
MAPK8TRAF6HPRD10346818 details
MAPK8NR3C1HPRD12351702 9199329 details
MAPK8XRCC6HPRD11749722 details
MAPK8MAP1BHPRD12689591 details
MAPK8VRK2BioGRID, IntAct18286207 details
MAPK8DAB2UniProt15894542 details
MAPK8MAPK9BioGRID, IntAct23602568 25284480 26186194 28514442 details
MAPK8CDC42BioGRID, IntAct25241761 25284480 details
MAPK8MAP3K11IntAct25284480 details
MAPK8RAC1IntAct25284480 details
MAPK8TCP1BioGRID, IntAct25852190 details
MAPK8NUP98BioGRID, IntAct25852190 details
MAPK8TKTBioGRID, IntAct25852190 details
MAPK8SUN2BioGRID, IntAct25852190 details
MAPK8CCT8BioGRID, IntAct25852190 details
MAPK8CCT6ABioGRID, IntAct25852190 details
MAPK8CCT3BioGRID, IntAct25852190 details
MAPK8CCT2BioGRID, IntAct25852190 details
MAPK8CCT4BioGRID, IntAct25852190 details
MAPK8PHLPP1BioGRID, IntAct26496610 details
MAPK8H2AC20IntAct26496610 details
MAPK8RABL3BioGRID, IntAct26496610 details
MAPK8COG2BioGRID, IntAct26496610 details
MAPK8CTSCBioGRID, IntAct26496610 details
MAPK8PSMD2BioGRID, IntAct26496610 details
MAPK8CRTC3BioGRID, IntAct26496610 details
MAPK8WDCPBioGRID, IntAct26496610 details
MAPK8CSNK2A2BioGRID, IntAct26496610 details
MAPK8STK11IPBioGRID, IntAct26496610 details
MAPK8TAF1DBioGRID, IntAct26496610 details
MAPK8BLMHBioGRID, IntAct26496610 details
MAPK8PRR3BioGRID, IntAct26496610 details
MAPK8BCL7ABioGRID, IntAct26496610 details
MAPK8TJP2BioGRID, IntAct26496610 details
MAPK8LAMP3BioGRID, IntAct28514442 details
MAPK8ATE1BioGRID, IntAct26186194 28514442 details
MAPK8KCNAB3BioGRID, IntAct26186194 28514442 details
MAPK8NEK4BioGRID, MINT25798074 details
MAPK8PRPSAP1BioGRID, IntAct31980649 details
MAPK8RUVBL1BioGRID, IntAct31980649 details
MAPK8ANKRD28BioGRID, IntAct31980649 details
MAPK8PPM1BBioGRID26344197 details
MAPK8ANXA7BioGRID26496610 details
MAPK8SF1BioGRID26496610 details
MAPK8H2AC18BioGRID26496610 details
MAPK8CTBP2BioGRID30585266 details