Entity Details

Primary name AAK1_HUMAN
Entity type UniProt
Source Source Link

Details

AccessionQ2M2I8
EntryNameAAK1_HUMAN
FullNameAP2-associated protein kinase 1
TaxID9606
Evidenceevidence at protein level
Length961
SequenceStatuscomplete
DateCreated2006-10-03
DateModified2021-06-02

Ontological Relatives

GenesAAK1

GO terms

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GOName
GO:0004674 protein serine/threonine kinase activity
GO:0005112 Notch binding
GO:0005524 ATP binding
GO:0005737 cytoplasm
GO:0005829 cytosol
GO:0005905 clathrin-coated pit
GO:0006468 protein phosphorylation
GO:0006897 endocytosis
GO:0019897 extrinsic component of plasma membrane
GO:0030136 clathrin-coated vesicle
GO:0031252 cell leading edge
GO:0032880 regulation of protein localization
GO:0035612 AP-2 adaptor complex binding
GO:0043195 terminal bouton
GO:0045747 positive regulation of Notch signaling pathway
GO:0046777 protein autophosphorylation
GO:0050821 protein stabilization
GO:0061024 membrane organization
GO:0106310 protein serine kinase activity
GO:0106311 protein threonine kinase activity
GO:2000369 regulation of clathrin-dependent endocytosis

Subcellular Location

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Subcellular Location
Cell junction
Cell membrane
Membrane

Domains

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DomainNameCategoryType
IPR000719 Protein kinase domainDomainDomain
IPR008271 Serine/threonine-protein kinase, active siteSiteActive site
IPR011009 Protein kinase-like domain superfamilyFamilyHomologous superfamily

Diseases

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Drugs

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DrugNameSourceType
DB12010 FostamatinibDrugbanksmall molecule