Entity Details

Primary name SPI1
Entity type gene
Source Source Link

Details

PrimaryID6688
RefseqGene
SymbolSPI1
NameSpi-1 proto-oncogene
Chromosome11
Location11p11.2
TaxID9606
Statuslive
SourceGenomegenomic
SourceOriginnatural
CreationDate1989-06-02
ModificationDate2021-06-11

Ontological Relatives

UniProt IDsSPI1_HUMAN

GO terms

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GOName
GO:0000122 negative regulation of transcription by RNA polymerase II
GO:0000785 chromatin
GO:0000976 transcription cis-regulatory region binding
GO:0000978 RNA polymerase II cis-regulatory region sequence-specific DNA binding
GO:0000981 DNA-binding transcription factor activity, RNA polymerase II-specific
GO:0000987 cis-regulatory region sequence-specific DNA binding
GO:0001216 DNA-binding transcription activator activity
GO:0001217 DNA-binding transcription repressor activity
GO:0001227 DNA-binding transcription repressor activity, RNA polymerase II-specific
GO:0001228 DNA-binding transcription activator activity, RNA polymerase II-specific
GO:0002314 germinal center B cell differentiation
GO:0002316 follicular B cell differentiation
GO:0002327 immature B cell differentiation
GO:0002357 defense response to tumor cell
GO:0002572 pro-T cell differentiation
GO:0002573 myeloid leukocyte differentiation
GO:0003682 chromatin binding
GO:0003700 DNA-binding transcription factor activity
GO:0003723 RNA binding
GO:0005634 nucleus
GO:0005654 nucleoplasm
GO:0005667 transcription regulator complex
GO:0006355 regulation of transcription, DNA-templated
GO:0006357 regulation of transcription by RNA polymerase II
GO:0007179 transforming growth factor beta receptor signaling pathway
GO:0008134 transcription factor binding
GO:0010628 positive regulation of gene expression
GO:0010629 negative regulation of gene expression
GO:0030154 cell differentiation
GO:0030218 erythrocyte differentiation
GO:0030225 macrophage differentiation
GO:0030851 granulocyte differentiation
GO:0031663 lipopolysaccharide-mediated signaling pathway
GO:0032088 negative regulation of NF-kappaB transcription factor activity
GO:0034401 chromatin organization involved in regulation of transcription
GO:0035019 somatic stem cell population maintenance
GO:0036462 TRAIL-activated apoptotic signaling pathway
GO:0042826 histone deacetylase binding
GO:0043011 myeloid dendritic cell differentiation
GO:0043314 negative regulation of neutrophil degranulation
GO:0043966 histone H3 acetylation
GO:0044027 hypermethylation of CpG island
GO:0045347 negative regulation of MHC class II biosynthetic process
GO:0045646 regulation of erythrocyte differentiation
GO:0045814 negative regulation of gene expression, epigenetic
GO:0045892 negative regulation of transcription, DNA-templated
GO:0045944 positive regulation of transcription by RNA polymerase II
GO:0051090 regulation of DNA-binding transcription factor activity
GO:0051525 NFAT protein binding
GO:0060033 anatomical structure regression
GO:0070102 interleukin-6-mediated signaling pathway
GO:0071361 cellular response to ethanol
GO:0090241 negative regulation of histone H4 acetylation
GO:0090402 oncogene-induced cell senescence
GO:0098508 endothelial to hematopoietic transition
GO:0120186 negative regulation of protein localization to chromatin
GO:0140297 DNA-binding transcription factor binding
GO:0140311 protein sequestering activity
GO:1900745 positive regulation of p38MAPK cascade
GO:1901223 negative regulation of NIK/NF-kappaB signaling
GO:1901674 regulation of histone H3-K27 acetylation
GO:1902262 apoptotic process involved in blood vessel morphogenesis
GO:1902895 positive regulation of pri-miRNA transcription by RNA polymerase II
GO:1904151 positive regulation of microglial cell mediated cytotoxicity
GO:1904178 negative regulation of adipose tissue development
GO:1904238 pericyte cell differentiation
GO:1905036 positive regulation of antifungal innate immune response
GO:1905453 regulation of myeloid progenitor cell differentiation
GO:2000529 positive regulation of myeloid dendritic cell chemotaxis

Diseases

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Interactions

71 interactions

InteractorPartnerSourcesPublicationsLink
SPI1TMX1BioGRID, IntAct21988832 details
SPI1PRKDCIntAct21575865 details
SPI1GFI1BioGRID, UniProt17197705 details
SPI1GATA2BioGRID, DIP, HPRD10364157 10411939 18250304 details
SPI1CSNK2A1BioGRID8632909 details
SPI1MAPK8BioGRID8632909 details
SPI1CREMBioGRID, HPRD7730336 details
SPI1ATF1BioGRID, HPRD7730336 details
SPI1ETS1BioGRID9681824 details
SPI1ETS2BioGRID9681824 details
SPI1ETV1BioGRID9681824 details
SPI1FOSBioGRID9681824 details
SPI1JUNBioGRID, HPRD12091339 9681824 details
SPI1CEBPBBioGRID, HPRD7594592 details
SPI1FUSBioGRID, HPRD9478924 details
SPI1SPIBBioGRID, HPRD10196196 details
SPI1NONOBioGRID, HPRD8626664 details
SPI1MITFBioGRID, HPRD9918847 details
SPI1IRF4BioGRID, HPRD10022840 12372320 details
SPI1NFYABioGRID9668064 details
SPI1CEBPABioGRID, HPRD12091339 16983342 details
SPI1MECP2BioGRID14647463 16331260 details
SPI1HDAC1BioGRID11593411 14647463 16331260 details
SPI1DNMT3ABioGRID, HPRD16331260 details
SPI1DNMT3BBioGRID, HPRD16331260 details
SPI1BCL6BioGRID19564417 details
SPI1TBPBioGRID, HPRD11593411 8434021 details
SPI1SIN3ABioGRID11593411 details
SPI1SKIBioGRID17621263 details
SPI1GATA1BioGRID, HPRD10364157 12202480 details
SPI1IRF1BioGRID11483597 9593745 details
SPI1IRF8BioGRID, HPRD10734131 11483597 17200120 9593745 details
SPI1RB1BioGRID, HPRD8434021 details
SPI1GATA3BioGRID10364157 details
SPI1RUNX1BioGRID10207087 details
SPI1IRF2BioGRID17200120 details
SPI1CREBBPHPRD10050886 details
SPI1HOXA10BioGRID, HPRD, IntAct18692240 details
SPI1PRKCDMINT24996056 details
SPI1HDAC3BioGRID17621263 details
SPI1RARABioGRID20159610 details
SPI1PMLBioGRID20159610 details
SPI1VAV1BioGRID19747912 details
SPI1ERGHPRD9681824 details
SPI1CEBPEHPRD12202480 details
SPI1NFATC1HPRD15304486 details
SPI1PIPHPRD11133986 details
SPI1SSRP1HPRD7594592 details
SPI1CEBPDHPRD7594592 details
SPI1KAT6AHPRD16702405 details
SPI1NFKB1HPRD9094628 details
SPI1XRCC5IntAct21575865 details
SPI1PARP1IntAct21575865 details
SPI1XRCC6IntAct21575865 details
SPI1YTHDC1BioGRID, IntAct30021884 details
SPI1DCPSBioGRID29478914 details
SPI1APBB1IPIntAct20159610 details
SPI1CSF3RIntAct20159610 details
SPI1FESIntAct20159610 details
SPI1FTLIntAct20159610 details
SPI1PSMB10IntAct20159610 details
SPI1TNFRSF18IntAct20159610 details
SPI1HCKIntAct20159610 details
SPI1KLF4IntAct17762869 details
SPI1CXCL14IntAct33179750 details
SPI1CXCL17IntAct33179750 details
SPI1IL12BIntAct33179750 details
SPI1IL27IntAct33179750 details
SPI1IL33IntAct33179750 details
SPI1LTBIntAct33179750 details
SPI1XCL2IntAct33179750 details