Entity Details

Primary name BTK
Entity type gene
Source Source Link

Details

PrimaryID695
RefseqGeneNG_009616
SymbolBTK
NameBruton tyrosine kinase
ChromosomeX
LocationXq22.1
TaxID9606
Statuslive
SourceGenomegenomic
SourceOriginnatural
CreationDate1998-08-06
ModificationDate2021-06-20

Ontological Relatives

UniProt IDsBTK_HUMAN

GO terms

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GOName
GO:0001805 positive regulation of type III hypersensitivity
GO:0001812 positive regulation of type I hypersensitivity
GO:0001818 negative regulation of cytokine production
GO:0002250 adaptive immune response
GO:0002344 B cell affinity maturation
GO:0002553 histamine secretion by mast cell
GO:0002721 regulation of B cell cytokine production
GO:0002755 MyD88-dependent toll-like receptor signaling pathway
GO:0002902 regulation of B cell apoptotic process
GO:0004713 protein tyrosine kinase activity
GO:0004714 transmembrane receptor protein tyrosine kinase activity
GO:0004715 non-membrane spanning protein tyrosine kinase activity
GO:0005524 ATP binding
GO:0005547 phosphatidylinositol-3,4,5-trisphosphate binding
GO:0005634 nucleus
GO:0005737 cytoplasm
GO:0005829 cytosol
GO:0005886 plasma membrane
GO:0006468 protein phosphorylation
GO:0007186 G protein-coupled receptor signaling pathway
GO:0007249 I-kappaB kinase/NF-kappaB signaling
GO:0007498 mesoderm development
GO:0016004 phospholipase activator activity
GO:0018108 peptidyl-tyrosine phosphorylation
GO:0019722 calcium-mediated signaling
GO:0030889 negative regulation of B cell proliferation
GO:0031410 cytoplasmic vesicle
GO:0034614 cellular response to reactive oxygen species
GO:0035556 intracellular signal transduction
GO:0038095 Fc-epsilon receptor signaling pathway
GO:0042113 B cell activation
GO:0042802 identical protein binding
GO:0043274 phospholipase binding
GO:0045087 innate immune response
GO:0045121 membrane raft
GO:0045579 positive regulation of B cell differentiation
GO:0046777 protein autophosphorylation
GO:0046872 metal ion binding
GO:0048469 cell maturation
GO:0048471 perinuclear region of cytoplasm
GO:0050853 B cell receptor signaling pathway
GO:0051092 positive regulation of NF-kappaB transcription factor activity
GO:0071226 cellular response to molecule of fungal origin
GO:0097190 apoptotic signaling pathway
GO:0098761 cellular response to interleukin-7

Diseases

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Interactions

124 interactions

InteractorPartnerSourcesPublicationsLink
BTKBTKBioGRID, HPRD, IntAct, MINT10427990 11231015 11373296 11527964 11577348 11598012 12445832 12573241 29290977 8629002 8630736 details
BTKBLNKBioGRID, HPRD, MINT10498607 10556826 12093870 16969585 21482705 21822214 details
BTKSH3BP5BioGRID, HPRD, IntAct10339589 9571151 details
BTKGTF2IBioGRID, HPRD, IntAct, MINT10373551 11313464 11373296 11934902 14623887 15096481 19214191 9012831 9837922 details
BTKIBTKBioGRID, HPRD, IntAct11577348 18596081 21482705 details
BTKMED28BioGRID, MINT16964398 details
BTKFASLGBioGRID, IntAct19807924 details
BTKGRB2BioGRID, IntAct19380743 20936779 details
BTKARRB1BioGRID, IntAct21988832 details
BTKPLAUBioGRID, IntAct21988832 details
BTKARBioGRID, IntAct24728074 details
BTKGAB1BioGRID, IntAct24728074 details
BTKMETBioGRID, IntAct24728074 details
BTKPIK3R3BioGRID, IntAct25814554 details
BTKBECN1BioGRID, IntAct25814554 details
BTKMRPS22BioGRID, IntAct25814554 details
BTKWASbhf-ucl, BioGRID, HPRD10068673 10427990 12235133 12769846 8892607 9742969 details
BTKMEOX2BioGRID, IntAct25910212 details
BTKGP6DIP19940238 details
BTKADAM15UniProt25825872 details
BTKPRKCBBioGRID, HPRD11598012 12679936 details
BTKPRKD1BioGRID, HPRD10561498 details
BTKKHDRBS1BioGRID, HPRD22745667 9201297 details
BTKRPS6KB1BioGRID16640565 details
BTKRPS6KB2BioGRID16640565 details
BTKFYNBioGRID8058772 details
BTKLYNBioGRID, HPRD11226282 11598012 8058772 8629002 8630736 details
BTKHCKBioGRID, HPRD8058772 details
BTKARHGAP17BioGRID, HPRD11431473 details
BTKCBLBioGRID, HPRD10427990 10826882 7629518 9408950 details
BTKGNAQBioGRID, HPRD9770463 details
BTKBCL2L11BioGRID15096481 details
BTKTLR8BioGRID, HPRD12724322 details
BTKTLR4BioGRID, HPRD12724322 details
BTKTLR6BioGRID, HPRD12724322 details
BTKTLR9BioGRID, HPRD12724322 details
BTKAPPBioGRID21832049 details
BTKSTAT5ABioGRID, HPRD11413148 7925280 8617237 details
BTKSMURF1BioGRID20804422 details
BTKAURKABioGRID28218735 details
BTKMDM2BioGRID29290977 details
BTKCOASYBioGRID19763791 details
BTKERBB3BioGRID22973453 details
BTKFCER1GIntAct11788586 details
BTKPRKCQHPRD, IntAct11788586 details
BTKARID3ABioGRID, HPRD, MINT15203319 19214191 details
BTKCD19HPRD, MINT10201980 19214191 details
BTKMALInnateDB22366891 details
BTKHSP90AB1IntAct22939624 details
BTKHSP90AA1BioGRID, IntAct22939624 28514442 details
BTKCAV1BioGRID, HPRD11751885 details
BTKJAK1BioGRID, HPRD9178903 details
BTKVAV1BioGRID, HPRD9201297 details
BTKEWSR1BioGRID, HPRD9201297 details
BTKPLCG2BioGRID, HPRD10981967 11507089 12093870 17290227 details
BTKCBLBBioGRID12093870 details
BTKMYD88BioGRID, HPRD12724322 details
BTKTIRAPBioGRID, HPRD12724322 16415872 16439361 details
BTKIRAK1BioGRID, HPRD12724322 details
BTKGNB1BioGRID11698416 details
BTKSYKBioGRID, HPRD10427990 11226282 11598012 8629002 8630736 details
BTKCORO1CBioGRID21080425 details
BTKTP53BioGRID, HPRD15355990 32807901 details
BTKITKHPRD11598012 12445832 12573241 8629002 8630736 details
BTKPRKCZHPRD11788586 7522330 details
BTKPRKCEHPRD11788586 7522330 details
BTKPRKCAHPRD11788586 7522330 details
BTKABL1HPRD11598012 12445832 12573241 8629002 8630736 details
BTKBMXHPRD12573241 details
BTKTECHPRD11598012 12445832 12573241 8629002 8630736 details
BTKGNA12HPRD9796816 details
BTKWASF2HPRD10427990 details
BTKSH2B2HPRD10872802 details
BTKGNG2HPRD11698416 7972043 details
BTKDAPP1HPRD11524430 details
BTKRELAHPRD15849198 details
BTKKITHPRD15007095 details
BTKPLCG1HPRD15184383 details
BTKPIP4K2BHPRD14614850 15046600 details
BTKPIP5K1AHPRD14614850 15046600 details
BTKTNFRSF10AHPRD15007095 details
BTKPIP5K1CHPRD14614850 15046600 details
BTKPIK3AP1HPRD11163197 details
BTKPIP4K2AHPRD14614850 15046600 details
BTKPIP4K2CHPRD14614850 15046600 details
BTKCMTM3HPRD15087455 details
BTKFASHPRD9751072 details
BTKRFTN1MINT19214191 details
BTKMYLK2BioGRID, IntAct21080425 details
BTKDDX3XBioGRID, IntAct21080425 details
BTKHRNRBioGRID, IntAct21080425 details
BTKRPS3BioGRID, IntAct21080425 details
BTKDBN1BioGRID, IntAct21080425 details
BTKACTA1BioGRID, IntAct21080425 details
BTKFLNABioGRID, IntAct21080425 details
BTKATP5F1ABioGRID, IntAct21080425 details
BTKTUBB4BBioGRID, IntAct21080425 details
BTKNDUFS1BioGRID, IntAct21080425 details
BTKHADHABioGRID, IntAct21080425 details
BTKAFG3L2BioGRID, IntAct21080425 details
BTKSPTA1BioGRID, IntAct21080425 details
BTKEEF1A2BioGRID, IntAct21080425 details
BTKGAPDHBioGRID, IntAct21080425 details
BTKKRT5BioGRID, IntAct21080425 details
BTKTWF1BioGRID, IntAct21080425 details
BTKACTN1BioGRID, IntAct21080425 details
BTKTUBA4ABioGRID, IntAct21080425 details
BTKATP5F1BBioGRID, IntAct21080425 details
BTKSFPQBioGRID, IntAct21080425 details
BTKMAP3K4BioGRID, IntAct28514442 details
BTKTTC9CBioGRID, IntAct28514442 details
BTKANKRD54BioGRID, IntAct28514442 details
BTKCDC37BioGRID, IntAct28514442 details
BTKKATNB1BioGRID, IntAct28514442 details
BTKMPP7BioGRID26344197 details
BTKHRASBioGRID30442766 details
BTKKRASBioGRID30442766 details
BTKNRASBioGRID30442766 details
BTKDCPSBioGRID29478914 details
BTKNR2C2BioGRID30463901 details
BTKNHLRC2BioGRID30397336 details
BTKKIF14BioGRID31586073 details
BTKPRC1BioGRID31586073 details
BTKDDX58BioGRID32513696 details