Entity Details

Primary name TGFB2
Entity type gene
Source Source Link

Details

PrimaryID7042
RefseqGeneNG_027721
SymbolTGFB2
Nametransforming growth factor beta 2
Chromosome1
Location1q41
TaxID9606
Statuslive
SourceGenomegenomic
SourceOriginnatural
CreationDate1990-03-05
ModificationDate2021-06-11

Ontological Relatives

UniProt IDsTGFB2_HUMAN

GO terms

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GOName
GO:0000902 cell morphogenesis
GO:0001501 skeletal system development
GO:0001540 amyloid-beta binding
GO:0001654 eye development
GO:0001666 response to hypoxia
GO:0001822 kidney development
GO:0001837 epithelial to mesenchymal transition
GO:0001843 neural tube closure
GO:0001942 hair follicle development
GO:0002576 platelet degranulation
GO:0003007 heart morphogenesis
GO:0003148 outflow tract septum morphogenesis
GO:0003149 membranous septum morphogenesis
GO:0003179 heart valve morphogenesis
GO:0003181 atrioventricular valve morphogenesis
GO:0003184 pulmonary valve morphogenesis
GO:0003203 endocardial cushion morphogenesis
GO:0003215 cardiac right ventricle morphogenesis
GO:0003222 ventricular trabecula myocardium morphogenesis
GO:0003274 endocardial cushion fusion
GO:0003289 atrial septum primum morphogenesis
GO:0003407 neural retina development
GO:0005102 signaling receptor binding
GO:0005114 type II transforming growth factor beta receptor binding
GO:0005125 cytokine activity
GO:0005160 transforming growth factor beta receptor binding
GO:0005576 extracellular region
GO:0005615 extracellular space
GO:0006468 protein phosphorylation
GO:0007179 transforming growth factor beta receptor signaling pathway
GO:0007435 salivary gland morphogenesis
GO:0007507 heart development
GO:0008083 growth factor activity
GO:0008219 cell death
GO:0008284 positive regulation of cell population proliferation
GO:0008285 negative regulation of cell population proliferation
GO:0008347 glial cell migration
GO:0008584 male gonad development
GO:0009611 response to wounding
GO:0009792 embryo development ending in birth or egg hatching
GO:0010002 cardioblast differentiation
GO:0010629 negative regulation of gene expression
GO:0010634 positive regulation of epithelial cell migration
GO:0010693 negative regulation of alkaline phosphatase activity
GO:0010718 positive regulation of epithelial to mesenchymal transition
GO:0010862 positive regulation of pathway-restricted SMAD protein phosphorylation
GO:0010936 negative regulation of macrophage cytokine production
GO:0014068 positive regulation of phosphatidylinositol 3-kinase signaling
GO:0016477 cell migration
GO:0016525 negative regulation of angiogenesis
GO:0030097 hemopoiesis
GO:0030199 collagen fibril organization
GO:0030307 positive regulation of cell growth
GO:0030308 negative regulation of cell growth
GO:0030326 embryonic limb morphogenesis
GO:0030424 axon
GO:0030509 BMP signaling pathway
GO:0030593 neutrophil chemotaxis
GO:0031069 hair follicle morphogenesis
GO:0031093 platelet alpha granule lumen
GO:0032147 activation of protein kinase activity
GO:0032570 response to progesterone
GO:0032874 positive regulation of stress-activated MAPK cascade
GO:0032909 regulation of transforming growth factor beta2 production
GO:0033630 positive regulation of cell adhesion mediated by integrin
GO:0034714 type III transforming growth factor beta receptor binding
GO:0035910 ascending aorta morphogenesis
GO:0042060 wound healing
GO:0042127 regulation of cell population proliferation
GO:0042416 dopamine biosynthetic process
GO:0042476 odontogenesis
GO:0042493 response to drug
GO:0042704 uterine wall breakdown
GO:0042803 protein homodimerization activity
GO:0043025 neuronal cell body
GO:0043525 positive regulation of neuron apoptotic process
GO:0045216 cell-cell junction organization
GO:0045726 positive regulation of integrin biosynthetic process
GO:0045747 positive regulation of Notch signaling pathway
GO:0045778 positive regulation of ossification
GO:0045787 positive regulation of cell cycle
GO:0045823 positive regulation of heart contraction
GO:0046580 negative regulation of Ras protein signal transduction
GO:0048103 somatic stem cell division
GO:0048566 embryonic digestive tract development
GO:0048666 neuron development
GO:0048699 generation of neurons
GO:0048839 inner ear development
GO:0050680 negative regulation of epithelial cell proliferation
GO:0050714 positive regulation of protein secretion
GO:0050778 positive regulation of immune response
GO:0051781 positive regulation of cell division
GO:0051794 regulation of timing of catagen
GO:0051795 positive regulation of timing of catagen
GO:0051891 positive regulation of cardioblast differentiation
GO:0060038 cardiac muscle cell proliferation
GO:0060065 uterus development
GO:0060317 cardiac epithelial to mesenchymal transition
GO:0060389 pathway-restricted SMAD protein phosphorylation
GO:0060395 SMAD protein signal transduction
GO:0060412 ventricular septum morphogenesis
GO:0060413 atrial septum morphogenesis
GO:0061626 pharyngeal arch artery morphogenesis
GO:0062009 secondary palate development
GO:0062023 collagen-containing extracellular matrix
GO:0097191 extrinsic apoptotic signaling pathway
GO:1902256 regulation of apoptotic process involved in outflow tract morphogenesis
GO:1902895 positive regulation of pri-miRNA transcription by RNA polymerase II
GO:1903701 substantia propria of cornea development
GO:1904888 cranial skeletal system development
GO:1905006 negative regulation of epithelial to mesenchymal transition involved in endocardial cushion formation
GO:1905007 positive regulation of epithelial to mesenchymal transition involved in endocardial cushion formation

Diseases

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Disease IDSourceNameDescription
614816 OMIMLoeys-Dietz syndrome 4 (LDS4)An aortic aneurysm syndrome with widespread systemic involvement. LDS4 is characterized by arterial tortuosity, aortic dissection, intracranial aneurysm and subarachnoid hemorrhage, hypertelorism, bifid uvula, pectus deformity, bicuspid aortic valve, arachnodactyly, scoliosis, foot deformities, dural ectasia, joint hyperflexibility, and thin skin with easy bruising and striae. The disease is caused by variants affecting the gene represented in this entry.