Entity Details

Primary name WAS
Entity type gene
Source Source Link

Details

PrimaryID7454
RefseqGeneNG_007877
SymbolWAS
NameWASP actin nucleation promoting factor
ChromosomeX
LocationXp11.23
TaxID9606
Statuslive
SourceGenomegenomic
SourceOriginnatural
CreationDate2000-11-17
ModificationDate2021-06-11

Ontological Relatives

UniProt IDsWASP_HUMAN

GO terms

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GOName
GO:0002625 regulation of T cell antigen processing and presentation
GO:0003779 actin binding
GO:0005634 nucleus
GO:0005829 cytosol
GO:0005884 actin filament
GO:0005886 plasma membrane
GO:0005911 cell-cell junction
GO:0006952 defense response
GO:0006955 immune response
GO:0007596 blood coagulation
GO:0008064 regulation of actin polymerization or depolymerization
GO:0008154 actin polymerization or depolymerization
GO:0008544 epidermis development
GO:0010591 regulation of lamellipodium assembly
GO:0012506 vesicle membrane
GO:0015629 actin cytoskeleton
GO:0016197 endosomal transport
GO:0017124 SH3 domain binding
GO:0019901 protein kinase binding
GO:0030041 actin filament polymerization
GO:0030048 actin filament-based movement
GO:0030695 GTPase regulator activity
GO:0031267 small GTPase binding
GO:0032488 Cdc42 protein signal transduction
GO:0035861 site of double-strand break
GO:0038096 Fc-gamma receptor signaling pathway involved in phagocytosis
GO:0042110 T cell activation
GO:0042802 identical protein binding
GO:0043274 phospholipase binding
GO:0045335 phagocytic vesicle
GO:0045944 positive regulation of transcription by RNA polymerase II
GO:0050852 T cell receptor signaling pathway
GO:0051492 regulation of stress fiber assembly
GO:0051497 negative regulation of stress fiber assembly
GO:0065003 protein-containing complex assembly
GO:0070062 extracellular exosome
GO:0071346 cellular response to interferon-gamma
GO:1905168 positive regulation of double-strand break repair via homologous recombination
GO:2000146 negative regulation of cell motility
GO:2000601 positive regulation of Arp2/3 complex-mediated actin nucleation

Diseases

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Interactions

96 interactions

InteractorPartnerSourcesPublicationsLink
WASCDC42BioGRID, DIP, HPRD, IntAct, mbinfo, MINT10068673 10360578 10360579 10684602 10713100 10724160 10802735 12235133 12769846 15075243 15361624 20936779 22252508 25502805 28539360 31515488 8625410 8643625 9422512 9660763 9742969 details
WASFGRBioGRID, HPRD, MINT10358777 7565724 8805332 8824280 details
WASNCK1BioGRID, HPRD, MINT10747096 11340081 12135674 24287595 7565724 details
WASFYNBioGRID, HPRD, MINT10224664 10532312 12431372 14707117 7565724 8805332 details
WASARPC1BHPRD, mbinfo, MINT10861055 11943145 details
WASHCKBioGRID, HPRD, mbinfo, MINT10068673 12029088 12235133 12769846 19234535 9742969 details
WASPSTPIP1BioGRID, HPRD, MINT14707117 19041431 9488710 details
WASPTPN12HPRD, IntAct, MINT11711533 14707117 15588985 19167335 details
WASWASDIP, HPRD, IntAct10724160 12769847 18650809 details
WASCSNK2A1BioGRID, HPRD, IntAct12769847 details
WASARPC3BioGRID, IntAct12769847 23148219 9889097 details
WASWIPF1BioGRID, DIP, HPRD, IntAct, mbinfo10202051 12591280 16055720 16488394 17213309 19805221 19817875 21988832 25416956 32296183 9405671 9694849 details
WASGAS7BioGRID, MINT16055720 26506240 details
WASWBP4BioGRID, MINT16055720 details
WASPTPRCIntAct19167335 details
WASPTPRGIntAct19167335 details
WASPTPRZ1IntAct19167335 details
WASPTPRBIntAct19167335 details
WASPTPRJIntAct19167335 details
WASPTPROIntAct19167335 details
WASPTPN22IntAct19167335 details
WASLCKBioGRID, MINT16107303 16293614 details
WASSNX9BioGRID, DIP, MINT17242350 19487689 details
WASDVL2BioGRID, MINT21516116 details
WASABI3BioGRID, IntAct, MINT21516116 25416956 details
WASFCHSD2BioGRID, IntAct21988832 details
WASRGS14BioGRID, IntAct21988832 details
WASWIPF2BioGRID, HPRD, IntAct12213210 16055720 21988832 details
WASRHOJBioGRID, HPRD, mbinfo10967094 14521508 details
WASROBO4mbinfo18948384 details
WASBTKbhf-ucl, BioGRID, HPRD10068673 10427990 12235133 12769846 8892607 9742969 details
WASPLCG1bhf-ucl, BioGRID, HPRD8805332 8824280 8892607 details
WASITKbhf-ucl, BioGRID, HPRD8810341 8892607 details
WASTECbhf-ucl, BioGRID, HPRD8892607 details
WASGRB2bhf-ucl, BioGRID, HPRD10224664 8805332 8892607 9307968 details
WASNCK2BioGRID, IntAct24287595 25416956 details
WASSORBS2BioGRID, IntAct25416956 details
WASAPPBP2BioGRID, IntAct25416956 details
WASUBASH3ABioGRID, IntAct32296183 details
WASTRIP10BioGRID, HPRD10713100 21516116 details
WASPIK3R1BioGRID, HPRD10358777 17242350 8805332 details
WASSRCBioGRID, HPRD8805332 8824280 details
WASCRKLBioGRID, HPRD11313252 details
WASVASPBioGRID, HPRD11598004 16055720 details
WASRAC1BioGRID, HPRD8643625 details
WASITSN2BioGRID, HPRD11748279 22558309 details
WASTNK2BioGRID16257963 details
WASARPC2BioGRID11943145 details
WASBAIAP2L1BioGRID22921828 details
WASTCERG1BioGRID16055720 details
WASPRPF40ABioGRID16055720 details
WASAPBB1BioGRID16055720 details
WASRANBP2BioGRID26261240 details
WASC5AR1BioGRID, HPRD12600272 details
WASCREBBPBioGRID32238831 details
WASARHGAP1HPRD8805223 details
WASCIB1HPRD16582881 details
WASSNX33MINT19487689 details
WASCTTNmbinfo15169891 details
WASRAC2mbinfo14521508 details
WASRAC3mbinfo14521508 details
WASRHOQmbinfo14521508 details
WASHCLS1HPRD, mbinfo15166239 21398607 details
WASEGFRBioGRID9307968 details
WASFYB1BioGRID, HPRD10747096 details
WASLCP2BioGRID, HPRD10747096 details
WASPACSIN1BioGRID19041431 details
WASPACSIN2BioGRID19041431 details
WASPACSIN3BioGRID19041431 details
WASFNBP1BioGRID16418535 19041431 details
WASSRGAP2BioGRID19041431 details
WASRBBP5BioGRID20574068 details
WASJMJD6BioGRID20574068 details
WASKDM4ABioGRID20574068 details
WASKDM6BBioGRID20574068 details
WASITSN1BioGRID15824104 18539136 details
WASCBLBioGRID23684068 details
WASCBLBBioGRID23684068 details
WASCSNK2A2HPRD12769847 details
WASACTC1HPRD12029088 details
WASDLG1HPRD15699074 details
WASNCKIPSDHPRD14559906 details
WASARHGEF7HPRD14559906 details
WASEVLHPRD16055720 details
WASENAHHPRD16055720 details
WASARPC4BioGRID, IntAct12769847 details
WASACTR3IntAct12769847 details
WASACTR2IntAct12769847 details
WASLRPPRCBioGRID, IntAct26496610 details
WASSAE1BioGRID26261240 details
WASUBA2BioGRID26261240 details
WASUBE2IBioGRID26261240 details
WASRELABioGRID26261240 details
WASATG16L1BioGRID30196744 details
WASCUL4BBioGRID30945288 details
WASRBM39BioGRID28302793 details