Entity Details

Primary name GDF5
Entity type gene
Source Source Link

Details

PrimaryID8200
RefseqGeneNG_008076
SymbolGDF5
Namegrowth differentiation factor 5
Chromosome20
Location20q11.22
TaxID9606
Statuslive
SourceGenomegenomic
SourceOriginnatural
CreationDate1998-11-25
ModificationDate2021-06-19

Ontological Relatives

UniProt IDsGDF5_HUMAN

GO terms

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GOName
GO:0005125 cytokine activity
GO:0005576 extracellular region
GO:0005615 extracellular space
GO:0005886 plasma membrane
GO:0007179 transforming growth factor beta receptor signaling pathway
GO:0007267 cell-cell signaling
GO:0008083 growth factor activity
GO:0009612 response to mechanical stimulus
GO:0010862 positive regulation of pathway-restricted SMAD protein phosphorylation
GO:0030326 embryonic limb morphogenesis
GO:0030509 BMP signaling pathway
GO:0030513 positive regulation of BMP signaling pathway
GO:0032331 negative regulation of chondrocyte differentiation
GO:0032332 positive regulation of chondrocyte differentiation
GO:0035136 forelimb morphogenesis
GO:0035137 hindlimb morphogenesis
GO:0036122 BMP binding
GO:0040014 regulation of multicellular organism growth
GO:0042802 identical protein binding
GO:0043524 negative regulation of neuron apoptotic process
GO:0043932 ossification involved in bone remodeling
GO:0045666 positive regulation of neuron differentiation
GO:0050680 negative regulation of epithelial cell proliferation
GO:0060390 regulation of SMAD protein signal transduction
GO:0060395 SMAD protein signal transduction
GO:0060591 chondroblast differentiation
GO:2001054 negative regulation of mesenchymal cell apoptotic process

Diseases

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Interactions

33 interactions

InteractorPartnerSourcesPublicationsLink
GDF5BMPR1BBioGRID, HPRD, MINT, UniProt11282024 16127465 19229295 9525338 details
GDF5BMPR2BioGRID, HPRD, MINT19229295 9525338 details
GDF5BMPR1ABioGRID, HPRD, IntAct, MINT, UniProt11282024 16127465 19229295 21543859 9525338 details
GDF5NOGUniProt16127465 details
GDF5GDF5MINT25174448 details
GDF5ACVR2ABioGRID, HPRD8702914 details
GDF5ACVR2BBioGRID, HPRD8702914 details
GDF5ACVR1BioGRID, HPRD8702914 details
GDF5HTRA1HPRD14973287 details
GDF5CHRDL2HPRD14660436 details
GDF5PKP3BioGRID, IntAct28514442 details
GDF5SERPINB13BioGRID, IntAct28514442 details
GDF5CALML5BioGRID, IntAct28514442 details
GDF5SNRKBioGRID, IntAct28514442 details
GDF5RAB3IPBioGRID, IntAct28514442 details
GDF5LRRC15BioGRID, IntAct28514442 details
GDF5RAB3IL1BioGRID, IntAct28514442 details
GDF5TMEM102BioGRID, IntAct28514442 details
GDF5VSIG8BioGRID, IntAct28514442 details
GDF5KPRPBioGRID, IntAct28514442 details
GDF5SELENBP1BioGRID, IntAct28514442 details
GDF5PLCD1BioGRID, IntAct28514442 details
GDF5SERPINB5BioGRID, IntAct28514442 details
GDF5CRABP2BioGRID, IntAct28514442 details
GDF5CALML3BioGRID, IntAct28514442 details
GDF5FABP4BioGRID, IntAct28514442 details
GDF5SERPINB2BioGRID, IntAct28514442 details
GDF5CRYABBioGRID, IntAct28514442 details
GDF5DUSP14BioGRID, IntAct28514442 details
GDF5SERPINB7BioGRID, IntAct28514442 details
GDF5PSIP1BioGRID, IntAct30021884 details
GDF5RPS6KB2BioGRID25324306 details
GDF5CTBP2BioGRID30585266 details