Entity Details

Primary name ZC12A_HUMAN
Entity type UniProt
Source Source Link

Details

AccessionQ5D1E8
EntryNameZC12A_HUMAN
FullNameEndoribonuclease ZC3H12A
TaxID9606
Evidenceevidence at protein level
Length599
SequenceStatuscomplete
DateCreated2008-06-10
DateModified2021-06-02

Ontological Relatives

GenesZC3H12A

GO terms

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GOName
GO:0000294 nuclear-transcribed mRNA catabolic process, endonucleolytic cleavage-dependent decay
GO:0000932 P-body
GO:0001525 angiogenesis
GO:0001933 negative regulation of protein phosphorylation
GO:0002230 positive regulation of defense response to virus by host
GO:0002757 immune response-activating signal transduction
GO:0003677 DNA binding
GO:0003682 chromatin binding
GO:0003723 RNA binding
GO:0003729 mRNA binding
GO:0003730 mRNA 3'-UTR binding
GO:0004521 endoribonuclease activity
GO:0004532 exoribonuclease activity
GO:0004540 ribonuclease activity
GO:0005634 nucleus
GO:0005654 nucleoplasm
GO:0005737 cytoplasm
GO:0005791 rough endoplasmic reticulum
GO:0005856 cytoskeleton
GO:0006915 apoptotic process
GO:0006954 inflammatory response
GO:0006974 cellular response to DNA damage stimulus
GO:0007399 nervous system development
GO:0010468 regulation of gene expression
GO:0010508 positive regulation of autophagy
GO:0010595 positive regulation of endothelial cell migration
GO:0010628 positive regulation of gene expression
GO:0010629 negative regulation of gene expression
GO:0010656 negative regulation of muscle cell apoptotic process
GO:0010884 positive regulation of lipid storage
GO:0010942 positive regulation of cell death
GO:0016032 viral process
GO:0016579 protein deubiquitination
GO:0030154 cell differentiation
GO:0030867 rough endoplasmic reticulum membrane
GO:0032088 negative regulation of NF-kappaB transcription factor activity
GO:0032689 negative regulation of interferon-gamma production
GO:0032691 negative regulation of interleukin-1 beta production
GO:0032715 negative regulation of interleukin-6 production
GO:0032720 negative regulation of tumor necrosis factor production
GO:0032991 protein-containing complex
GO:0034599 cellular response to oxidative stress
GO:0035198 miRNA binding
GO:0035613 RNA stem-loop binding
GO:0035925 mRNA 3'-UTR AU-rich region binding
GO:0036464 cytoplasmic ribonucleoprotein granule
GO:0042149 cellular response to glucose starvation
GO:0042307 positive regulation of protein import into nucleus
GO:0042406 extrinsic component of endoplasmic reticulum membrane
GO:0043022 ribosome binding
GO:0043031 negative regulation of macrophage activation
GO:0043124 negative regulation of I-kappaB kinase/NF-kappaB signaling
GO:0044828 negative regulation by host of viral genome replication
GO:0045019 negative regulation of nitric oxide biosynthetic process
GO:0045600 positive regulation of fat cell differentiation
GO:0045766 positive regulation of angiogenesis
GO:0045944 positive regulation of transcription by RNA polymerase II
GO:0046872 metal ion binding
GO:0050852 T cell receptor signaling pathway
GO:0051259 protein complex oligomerization
GO:0051607 defense response to virus
GO:0055118 negative regulation of cardiac muscle contraction
GO:0061014 positive regulation of mRNA catabolic process
GO:0061158 3'-UTR-mediated mRNA destabilization
GO:0071222 cellular response to lipopolysaccharide
GO:0071347 cellular response to interleukin-1
GO:0071356 cellular response to tumor necrosis factor
GO:0090501 RNA phosphodiester bond hydrolysis
GO:0090502 RNA phosphodiester bond hydrolysis, endonucleolytic
GO:0098586 cellular response to virus
GO:1900016 negative regulation of cytokine production involved in inflammatory response
GO:1900119 positive regulation of execution phase of apoptosis
GO:1900745 positive regulation of p38MAPK cascade
GO:1901223 negative regulation of NIK/NF-kappaB signaling
GO:1903003 positive regulation of protein deubiquitination
GO:1903799 negative regulation of production of miRNAs involved in gene silencing by miRNA
GO:1903936 cellular response to sodium arsenite
GO:1904637 cellular response to ionomycin
GO:1990869 cellular response to chemokine
GO:2000320 negative regulation of T-helper 17 cell differentiation
GO:2000379 positive regulation of reactive oxygen species metabolic process
GO:2000627 positive regulation of miRNA catabolic process

Subcellular Location

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Subcellular Location
Cytoplasm
Cytoplasmic granule
Nucleus
Rough endoplasmic reticulum membrane

Domains

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DomainNameCategoryType
IPR021869 Ribonuclease Zc3h12a-like, NYN domainDomainDomain
IPR040546 Rege-1, UBA-like domainDomainDomain
IPR040757 Endoribonuclease Regnase 1/ZC3H12, C-terminal domainDomainDomain

Diseases

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Interactions

28 interactions

InteractorPartnerSourcesPublicationsLink
ZC12A_HUMANTANK_HUMANBioGRID, HPRD, IntAct16189514 25861989 details
ZC12A_HUMANAHSP_HUMANBioGRID, HPRD, IntAct16189514 25416956 details
ZC12A_HUMANEP300_HUMANBioGRID, IntAct21988832 details
ZC12A_HUMANIMA1_HUMANBioGRID, IntAct21988832 details
ZC12A_HUMANSMAD3_HUMANBioGRID, IntAct21988832 details
ZC12A_HUMANFBW1A_HUMANBioGRID, IntAct, MINT21900206 21988832 24270572 details
ZC12A_HUMANCYFP2_HUMANBioGRID, IntAct21988832 details
ZC12A_HUMANAIMP2_HUMANBioGRID, MINT21900206 details
ZC12A_HUMANIRAK2_HUMANBioGRID, IntAct21903422 details
ZC12A_HUMANNEMO_HUMANBioGRID, MINT24270572 25861989 details
ZC12A_HUMANP4HA3_HUMANBioGRID, IntAct25416956 32296183 details
ZC12A_HUMANDJB13_HUMANBioGRID, IntAct32296183 details
ZC12A_HUMANTRI63_HUMANBioGRID, IntAct31391242 details
ZC12A_HUMANTRI55_HUMANBioGRID, IntAct31391242 details
ZC12A_HUMANUBC_HUMANBioGRID21115689 24270572 details
ZC12A_HUMANZC12A_HUMANBioGRID19909337 23355615 29471506 29743536 details
ZC12A_HUMANZC12D_HUMANBioGRID26134560 details
ZC12A_HUMANHIF1A_HUMANBioGRID24048733 details
ZC12A_HUMANIL6_HUMANBioGRID29743536 details
ZC12A_HUMANSHBG_HUMANHPRD15862967 details
ZC12A_HUMANIKKB_HUMANInnateDB22037600 details
ZC12A_HUMANUBP10_HUMANBioGRID, MINT24270572 25861989 details
ZC12A_HUMANTRAF6_HUMANBioGRID25861989 details
ZC12A_HUMANMAVS_HUMANBioGRID29920243 details
ZC12A_HUMANTRAF3_HUMANBioGRID29920243 details
ZC12A_HUMANTBK1_HUMANBioGRID29920243 details
ZC12A_HUMANIKKE_HUMANBioGRID29920243 details
ZC12A_HUMANIRF3_HUMANBioGRID29920243 details