Entity Details

Primary name S12A1_HUMAN
Entity type UniProt
Source Source Link

Details

AccessionQ13621
EntryNameS12A1_HUMAN
FullNameSolute carrier family 12 member 1
TaxID9606
Evidenceevidence at protein level
Length1099
SequenceStatuscomplete
DateCreated2001-01-11
DateModified2021-06-02

Ontological Relatives

GenesSLC12A1

GO terms

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GOName
GO:0005886 plasma membrane
GO:0006811 ion transport
GO:0006884 cell volume homeostasis
GO:0008511 sodium:potassium:chloride symporter activity
GO:0015379 potassium:chloride symporter activity
GO:0016020 membrane
GO:0016021 integral component of membrane
GO:0016324 apical plasma membrane
GO:0034220 ion transmembrane transport
GO:0035725 sodium ion transmembrane transport
GO:0055064 chloride ion homeostasis
GO:0055075 potassium ion homeostasis
GO:0055078 sodium ion homeostasis
GO:0070062 extracellular exosome
GO:1902476 chloride transmembrane transport
GO:1990573 potassium ion import across plasma membrane

Subcellular Location

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Subcellular Location
Apical cell membrane

Domains

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DomainNameCategoryType
IPR002443 Solute carrier family 12 member 1/2FamilyFamily
IPR002445 Solute carrier family 12 member 1FamilyFamily
IPR004841 Amino acid permease/ SLC12A domainDomainDomain
IPR004842 SLC12A transporter familyFamilyFamily
IPR013612 Amino acid permease, N-terminalDomainDomain
IPR018491 SLC12A transporter, C-terminalDomainDomain

Diseases

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Drugs

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DrugNameSourceType
DB00214 TorasemideDrugbanksmall molecule
DB00232 MethyclothiazideDrugbanksmall molecule
DB00310 ChlorthalidoneDrugbanksmall molecule
DB00534 ChlormerodrinDrugbanksmall molecule
DB00695 FurosemideDrugbanksmall molecule
DB00761 Potassium chlorideDrugbanksmall molecule
DB00774 HydroflumethiazideDrugbanksmall molecule
DB00887 BumetanideDrugbanksmall molecule
DB00903 Etacrynic acidDrugbanksmall molecule
DB01325 QuinethazoneDrugbanksmall molecule
DB02925 PiretanideDrugbanksmall molecule
DB11098 Potassium bicarbonateSwissprotsmall molecule
DB13620 Potassium gluconateSwissprotsmall molecule
DB14500 PotassiumDrugbanksmall molecule

Interactions

3 interactions