Entity Details

Primary name PGAP1_HUMAN
Entity type UniProt
Source Source Link

Details

AccessionQ75T13
EntryNamePGAP1_HUMAN
FullNameGPI inositol-deacylase
TaxID9606
Evidenceevidence at protein level
Length922
SequenceStatuscomplete
DateCreated2007-02-06
DateModified2021-06-02

Ontological Relatives

GenesPGAP1

GO terms

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GOName
GO:0005783 endoplasmic reticulum
GO:0005789 endoplasmic reticulum membrane
GO:0006505 GPI anchor metabolic process
GO:0006888 endoplasmic reticulum to Golgi vesicle-mediated transport
GO:0007605 sensory perception of sound
GO:0009880 embryonic pattern specification
GO:0009948 anterior/posterior axis specification
GO:0015031 protein transport
GO:0016021 integral component of membrane
GO:0016255 attachment of GPI anchor to protein
GO:0021871 forebrain regionalization
GO:0050185 phosphatidylinositol deacylase activity
GO:1902953 positive regulation of ER to Golgi vesicle-mediated transport

Subcellular Location

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Subcellular Location
Endoplasmic reticulum membrane

Domains

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DomainNameCategoryType
IPR012908 GPI inositol-deacylase PGAP1-likeFamilyFamily
IPR029058 Alpha/Beta hydrolase foldFamilyHomologous superfamily
IPR039529 GPI inositol-deacylaseFamilyFamily

Diseases

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Disease IDSourceNameDescription
615802 OMIMMental retardation, autosomal recessive 42 (MRT42)A disorder characterized by significantly below average general intellectual functioning associated with impairments in adaptive behavior and manifested during the developmental period. The disease is caused by variants affecting the gene represented in this entry.

Interactions

2 interactions

InteractorPartnerSourcesPublicationsLink
PGAP1_HUMANMYC_HUMANIntAct17353931 details
PGAP1_HUMANMLP3A_HUMANBioGRID22963397 details