Entity Details

Primary name MAGI2_HUMAN
Entity type UniProt
Source Source Link

Details

AccessionQ86UL8
EntryNameMAGI2_HUMAN
FullNameMembrane-associated guanylate kinase, WW and PDZ domain-containing protein 2
TaxID9606
Evidenceevidence at protein level
Length1455
SequenceStatuscomplete
DateCreated2003-10-03
DateModified2021-06-02

Ontological Relatives

GenesMAGI2

GO terms

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GOName
GO:0002092 positive regulation of receptor internalization
GO:0003402 planar cell polarity pathway involved in axis elongation
GO:0005634 nucleus
GO:0005737 cytoplasm
GO:0005770 late endosome
GO:0005886 plasma membrane
GO:0005911 cell-cell junction
GO:0005923 bicellular tight junction
GO:0007165 signal transduction
GO:0007399 nervous system development
GO:0008285 negative regulation of cell population proliferation
GO:0010976 positive regulation of neuron projection development
GO:0014069 postsynaptic density
GO:0019902 phosphatase binding
GO:0030159 signaling receptor complex adaptor activity
GO:0030336 negative regulation of cell migration
GO:0030425 dendrite
GO:0031697 beta-1 adrenergic receptor binding
GO:0032516 positive regulation of phosphoprotein phosphatase activity
GO:0032926 negative regulation of activin receptor signaling pathway
GO:0032991 protein-containing complex
GO:0036057 slit diaphragm
GO:0038180 nerve growth factor signaling pathway
GO:0043113 receptor clustering
GO:0045202 synapse
GO:0046332 SMAD binding
GO:0048471 perinuclear region of cytoplasm
GO:0051898 negative regulation of protein kinase B signaling
GO:0060395 SMAD protein signal transduction
GO:0070699 type II activin receptor binding
GO:0072015 glomerular visceral epithelial cell development
GO:1990090 cellular response to nerve growth factor stimulus

Subcellular Location

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Subcellular Location
Cell junction
Cell membrane
Cytoplasm
Late endosome

Domains

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DomainNameCategoryType
IPR001202 WW domainDomainDomain
IPR001478 PDZ domainDomainDomain
IPR008144 Guanylate kinase-like domainDomainDomain
IPR008145 Guanylate kinase/L-type calcium channel beta subunitDomainDomain
IPR020590 Guanylate kinase, conserved siteSiteConserved site
IPR027417 P-loop containing nucleoside triphosphate hydrolaseFamilyHomologous superfamily
IPR030036 Membrane-associated guanylate kinase, WW and PDZ domain-containing protein 2FamilyFamily
IPR036020 WW domain superfamilyFamilyHomologous superfamily
IPR036034 PDZ superfamilyFamilyHomologous superfamily

Diseases

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Interactions

31 interactions

InteractorPartnerSourcesPublicationsLink
MAGI2_HUMANDSCL1_HUMANBioGRID, HPRD, IntAct12421765 details
MAGI2_HUMANPLXB3_HUMANBioGRID, HPRD, IntAct12421765 details
MAGI2_HUMANRPGF2_HUMANHPRD, MINT10548487 details
MAGI2_HUMANADRB1_HUMANBioGRID, HPRD, IntAct, MINT11526121 16316992 16533813 details
MAGI2_HUMANTGFA_HUMANHPRD, MINT15652357 details
MAGI2_HUMANARRD3_HUMANBioGRID, IntAct23236378 details
MAGI2_HUMANPDZ11_HUMANBioGRID, IntAct32296183 details
MAGI2_HUMANDLGP2_HUMANIntAct32296183 details
MAGI2_HUMANDLGP3_HUMANBioGRID, IntAct32296183 details
MAGI2_HUMANPKHF2_HUMANBioGRID, IntAct32296183 details
MAGI2_HUMANRSMB_HUMANBioGRID, IntAct32296183 details
MAGI2_HUMANMORN4_HUMANBioGRID, IntAct32296183 details
MAGI2_HUMANATN1_HUMANBioGRID, HPRD9647693 details
MAGI2_HUMANAVR2A_HUMANBioGRID, HPRD10681527 15451561 details
MAGI2_HUMANAGRB1_HUMANBioGRID23782696 details
MAGI2_HUMANPTEN_HUMANBioGRID, HPRD10760291 11707428 details
MAGI2_HUMANKS6A1_HUMANBioGRID30726710 details
MAGI2_HUMANCRFR1_HUMANBioGRID23576434 details
MAGI2_HUMANDLGP1_HUMANBioGRID32296183 details
MAGI2_HUMANTMG4_HUMANBioGRID23873930 details
MAGI2_HUMANGRID2_HUMANHPRD12589829 details
MAGI2_HUMANMAGI2_HUMANHPRD10681527 10760291 details
MAGI2_HUMANDLL1_HUMANHPRD14529612 details
MAGI2_HUMANAMOL1_HUMANIntAct17353931 details
MAGI2_HUMANRPB1_HUMANIntAct17353931 details
MAGI2_HUMANRPB2_HUMANIntAct17353931 details
MAGI2_HUMANEPHA4_HUMANIntAct31413325 details
MAGI2_HUMANCTNB1_HUMANBioGRID, HPRD11526121 11826105 details
MAGI2_HUMANERBB4_HUMANBioGRID17579610 details
MAGI2_HUMANSMAD3_HUMANHPRD10681527 details
MAGI2_HUMANCTND2_HUMANHPRD10080919 details