Entity Details

Primary name IASPP_HUMAN
Entity type UniProt
Source Source Link

Details

AccessionQ8WUF5
EntryNameIASPP_HUMAN
FullNameRelA-associated inhibitor
TaxID9606
Evidenceevidence at protein level
Length828
SequenceStatuscomplete
DateCreated2003-08-15
DateModified2021-06-02

Ontological Relatives

GenesPPP1R13L

GO terms

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GOName
GO:0000122 negative regulation of transcription by RNA polymerase II
GO:0003215 cardiac right ventricle morphogenesis
GO:0003229 ventricular cardiac muscle tissue development
GO:0003714 transcription corepressor activity
GO:0005634 nucleus
GO:0005654 nucleoplasm
GO:0005829 cytosol
GO:0006351 transcription, DNA-templated
GO:0006357 regulation of transcription by RNA polymerase II
GO:0006915 apoptotic process
GO:0008134 transcription factor binding
GO:0009791 post-embryonic development
GO:0030054 cell junction
GO:0031076 embryonic camera-type eye development
GO:0035264 multicellular organism growth
GO:0042633 hair cycle
GO:0042802 identical protein binding
GO:0045171 intercellular bridge
GO:0045296 cadherin binding
GO:0045597 positive regulation of cell differentiation
GO:0048871 multicellular organismal homeostasis
GO:0060048 cardiac muscle contraction
GO:1901796 regulation of signal transduction by p53 class mediator

Subcellular Location

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Subcellular Location
Cytoplasm
Nucleus

Domains

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DomainNameCategoryType
IPR001452 SH3 domainDomainDomain
IPR002110 Ankyrin repeatRepeatRepeat
IPR020683 Ankyrin repeat-containing domainDomainDomain
IPR028320 RelA-associated inhibitorFamilyFamily
IPR036028 SH3-like domain superfamilyFamilyHomologous superfamily
IPR036770 Ankyrin repeat-containing domain superfamilyFamilyHomologous superfamily
IPR042722 RelA-associated inhibitor, SH3 domainDomainDomain

Diseases

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Interactions

25 interactions

InteractorPartnerSourcesPublicationsLink
IASPP_HUMANP53_HUMANBioGRID, DIP, HPRD, IntAct, MINT12524540 17906639 18275817 19246451 20840860 21513714 23443559 23623661 details
IASPP_HUMANPP1A_HUMANBioGRID, HPRD, IntAct, MINT15231748 21998301 22321011 23088536 26186194 27173435 27880917 28330616 28514442 29743530 unassigned1312 details
IASPP_HUMANPP1B_HUMANBioGRID, IntAct, MINT21998301 26496610 27173435 27880917 28330616 29743530 unassigned1312 details
IASPP_HUMANIASPP_HUMANDIP, HPRD, IntAct10336463 12134007 18275817 23623661 details
IASPP_HUMANRAN_HUMANIntAct24855949 details
IASPP_HUMANP63_HUMANDIP18275817 details
IASPP_HUMANP73_HUMANDIP18275817 details
IASPP_HUMANTF65_HUMANBioGRID, HPRD10336463 12134007 details
IASPP_HUMANSP1_HUMANBioGRID, HPRD12134007 details
IASPP_HUMANSRPK2_HUMANBioGRID26167880 details
IASPP_HUMANKEAP1_HUMANBioGRID29033244 details
IASPP_HUMANEP300_HUMANBioGRID, MINT21513714 25675294 details
IASPP_HUMANCDK1_HUMANIntAct23623661 details
IASPP_HUMANMARE1_HUMANBioGRID, IntAct26186194 26496610 28514442 29162697 29743530 34079125 details
IASPP_HUMANPP1R7_HUMANBioGRID, IntAct27173435 unassigned1312 details
IASPP_HUMANSHAN3_HUMANMINT21653829 details
IASPP_HUMANCBP_HUMANBioGRID25675294 details
IASPP_HUMANPPR3A_HUMANBioGRID24366813 29743530 details
IASPP_HUMANNF2L2_HUMANBioGRID29033244 details
IASPP_HUMANCEP55_HUMANBioGRID29743530 details
IASPP_HUMANNFKB2_HUMANBioGRID29743530 details
IASPP_HUMANMARE3_HUMANBioGRID29743530 details
IASPP_HUMANNFKB1_HUMANBioGRID29743530 details
IASPP_HUMANATG5_HUMANBioGRID24777476 details
IASPP_HUMANA16L1_HUMANBioGRID24777476 details