Entity Details

Primary name NANO1_HUMAN
Entity type UniProt
Source Source Link

Details

AccessionQ8WY41
EntryNameNANO1_HUMAN
FullNameNanos homolog 1
TaxID9606
Evidenceevidence at protein level
Length292
SequenceStatuscomplete
DateCreated2004-02-02
DateModified2021-06-02

Ontological Relatives

GenesNANOS1

GO terms

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GOName
GO:0001558 regulation of cell growth
GO:0001894 tissue homeostasis
GO:0003729 mRNA binding
GO:0005737 cytoplasm
GO:0008270 zinc ion binding
GO:0010608 posttranscriptional regulation of gene expression
GO:0010631 epithelial cell migration
GO:0016477 cell migration
GO:0017148 negative regulation of translation
GO:0030371 translation repressor activity
GO:0048471 perinuclear region of cytoplasm
GO:0048477 oogenesis
GO:0098749 cerebellar neuron development
GO:1900153 positive regulation of nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay

Subcellular Location

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Subcellular Location
Cytoplasm

Domains

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DomainNameCategoryType
IPR008705 Nanos/Xcat2FamilyFamily
IPR024161 Zinc finger, nanos-typeDomainDomain
IPR038129 Nanos domain superfamilyFamilyHomologous superfamily

Diseases

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Disease IDSourceNameDescription
615413 OMIMSpermatogenic failure 12 (SPGF12)An infertility disorder caused by spermatogenesis defects. It results in decreased sperm motility, concentration, and multiple sperm structural defects. Non-obstructive azoospermia, oligozoospermia and oligo-astheno-teratozoospermia are features observed in SPGF12 patients. The disease is caused by variants affecting the gene represented in this entry.