Entity Details

Primary name IRF7_HUMAN
Entity type UniProt
Source Source Link

Details

AccessionQ92985
EntryNameIRF7_HUMAN
FullNameInterferon regulatory factor 7
TaxID9606
Evidenceevidence at protein level
Length503
SequenceStatuscomplete
DateCreated1997-11-01
DateModified2021-06-02

Ontological Relatives

GenesIRF7

GO terms

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GOName
GO:0000122 negative regulation of transcription by RNA polymerase II
GO:0000785 chromatin
GO:0000978 RNA polymerase II cis-regulatory region sequence-specific DNA binding
GO:0000981 DNA-binding transcription factor activity, RNA polymerase II-specific
GO:0002376 immune system process
GO:0002819 regulation of adaptive immune response
GO:0003677 DNA binding
GO:0005634 nucleus
GO:0005654 nucleoplasm
GO:0005737 cytoplasm
GO:0005829 cytosol
GO:0006357 regulation of transcription by RNA polymerase II
GO:0006974 cellular response to DNA damage stimulus
GO:0009615 response to virus
GO:0010008 endosome membrane
GO:0016064 immunoglobulin mediated immune response
GO:0019043 establishment of viral latency
GO:0032479 regulation of type I interferon production
GO:0032481 positive regulation of type I interferon production
GO:0032727 positive regulation of interferon-alpha production
GO:0032728 positive regulation of interferon-beta production
GO:0034124 regulation of MyD88-dependent toll-like receptor signaling pathway
GO:0034127 regulation of MyD88-independent toll-like receptor signaling pathway
GO:0035666 TRIF-dependent toll-like receptor signaling pathway
GO:0039530 MDA-5 signaling pathway
GO:0045087 innate immune response
GO:0045655 regulation of monocyte differentiation
GO:0045893 positive regulation of transcription, DNA-templated
GO:0045944 positive regulation of transcription by RNA polymerase II
GO:0050776 regulation of immune response
GO:0051607 defense response to virus
GO:0060333 interferon-gamma-mediated signaling pathway
GO:0060337 type I interferon signaling pathway
GO:0060340 positive regulation of type I interferon-mediated signaling pathway
GO:1990837 sequence-specific double-stranded DNA binding
GO:2000110 negative regulation of macrophage apoptotic process

Subcellular Location

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Subcellular Location
Cytoplasm
Nucleus

Domains

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DomainNameCategoryType
IPR001346 Interferon regulatory factor DNA-binding domainDomainDomain
IPR008984 SMAD/FHA domain superfamilyFamilyHomologous superfamily
IPR017855 SMAD-like domain superfamilyFamilyHomologous superfamily
IPR019471 Interferon regulatory factor-3DomainDomain
IPR019817 Interferon regulatory factor, conserved siteSiteConserved site
IPR036388 Winged helix-like DNA-binding domain superfamilyFamilyHomologous superfamily
IPR036390 Winged helix DNA-binding domain superfamilyFamilyHomologous superfamily

Diseases

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Interactions

47 interactions

InteractorPartnerSourcesPublicationsLink
IRF7_HUMANTBK1_HUMANBioGRID, MINT17599067 details
IRF7_HUMANUBE2B_HUMANIntAct19549727 details
IRF7_HUMANACADS_HUMANBioGRID, IntAct21988832 details
IRF7_HUMANGSH0_HUMANBioGRID, IntAct21988832 details
IRF7_HUMANINSR_HUMANBioGRID, IntAct21988832 details
IRF7_HUMANTRAF6_HUMANBioGRID, HPRD, InnateDB15361868 18710948 21183682 21743479 22095711 26224488 30927622 details
IRF7_HUMANIRAK1_HUMANBioGRID, HPRD, IntAct15767370 21903422 details
IRF7_HUMANPALD_HUMANBioGRID, IntAct21903422 details
IRF7_HUMANCCD47_HUMANBioGRID, IntAct21903422 details
IRF7_HUMANARAF_HUMANBioGRID, IntAct21903422 details
IRF7_HUMANAIP_HUMANBioGRID, IntAct21903422 details
IRF7_HUMANTLK2_HUMANBioGRID, IntAct21903422 details
IRF7_HUMANLTN1_HUMANBioGRID, IntAct21903422 details
IRF7_HUMANTR61B_HUMANBioGRID, IntAct21903422 30833792 details
IRF7_HUMANIKKA_HUMANUniProt18922877 details
IRF7_HUMANP53_HUMANBioGRID, IntAct18307271 25505178 details
IRF7_HUMANIRF3_HUMANBioGRID, HPRD11162841 18641315 details
IRF7_HUMANIRF7_HUMANBioGRID11162841 22588174 details
IRF7_HUMANTANK_HUMANBioGRID17823124 details
IRF7_HUMANMYD88_HUMANBioGRID, HPRD15361868 16484229 details
IRF7_HUMANEP300_HUMANBioGRID, HPRD12604599 details
IRF7_HUMANCBP_HUMANBioGRID, HPRD12604599 details
IRF7_HUMANTIF1B_HUMANBioGRID21940674 details
IRF7_HUMANSMAD3_HUMANBioGRID14729983 details
IRF7_HUMANSMAD4_HUMANBioGRID14729983 details
IRF7_HUMANSMAD2_HUMANBioGRID14729983 details
IRF7_HUMANSOCS1_HUMANBioGRID29712772 details
IRF7_HUMANSOCS3_HUMANBioGRID29712772 details
IRF7_HUMANTCAM1_HUMANHPRD14739303 details
IRF7_HUMANPIAS4_HUMANBioGRID, HPRD, MINT15251447 details
IRF7_HUMANMAFB_HUMANBioGRID, InnateDB20581830 details
IRF7_HUMANIKKE_HUMANUniProt19153231 details
IRF7_HUMANALK_HUMANBioGRID14968112 details
IRF7_HUMANFADD_HUMANBioGRID21183682 details
IRF7_HUMANTNAP3_HUMANBioGRID20392859 details
IRF7_HUMANRO52_HUMANBioGRID20668674 details
IRF7_HUMANMAVS_HUMANBioGRID, HPRD16153868 details
IRF7_HUMANDEAF1_HUMANBioGRID23846693 details
IRF7_HUMANNMI_HUMANBioGRID23956435 details
IRF7_HUMANSUMO2_HUMANBioGRID24267727 details
IRF7_HUMANSUMO3_HUMANBioGRID24267727 details
IRF7_HUMANRNF31_HUMANBioGRID27903798 details
IRF7_HUMANOTUD1_HUMANBioGRID30100102 details
IRF7_HUMANTRBP2_HUMANBioGRID30927622 details
IRF7_HUMANKAT2A_HUMANHPRD12374802 details
IRF7_HUMANKAT2B_HUMANHPRD12374802 details
IRF7_HUMANTCAM2_HUMANHPRD14517278 details