Entity Details

Primary name MED12_HUMAN
Entity type UniProt
Source Source Link

Details

AccessionQ93074
EntryNameMED12_HUMAN
FullNameMediator of RNA polymerase II transcription subunit 12
TaxID9606
Evidenceevidence at protein level
Length2177
SequenceStatuscomplete
DateCreated1997-11-01
DateModified2021-06-02

Ontological Relatives

GenesMED12

GO terms

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GOName
GO:0000151 ubiquitin ligase complex
GO:0000978 RNA polymerase II cis-regulatory region sequence-specific DNA binding
GO:0001843 neural tube closure
GO:0003682 chromatin binding
GO:0003712 transcription coregulator activity
GO:0003713 transcription coactivator activity
GO:0005634 nucleus
GO:0005654 nucleoplasm
GO:0006357 regulation of transcription by RNA polymerase II
GO:0007492 endoderm development
GO:0007507 heart development
GO:0008013 beta-catenin binding
GO:0008022 protein C-terminus binding
GO:0014003 oligodendrocyte development
GO:0014044 Schwann cell development
GO:0016020 membrane
GO:0016592 mediator complex
GO:0019827 stem cell population maintenance
GO:0019904 protein domain specific binding
GO:0021510 spinal cord development
GO:0030374 nuclear receptor coactivator activity
GO:0036342 post-anal tail morphogenesis
GO:0042809 vitamin D receptor binding
GO:0045893 positive regulation of transcription, DNA-templated
GO:0045944 positive regulation of transcription by RNA polymerase II
GO:0046966 thyroid hormone receptor binding
GO:0048702 embryonic neurocranium morphogenesis
GO:0060070 canonical Wnt signaling pathway
GO:0060071 Wnt signaling pathway, planar cell polarity pathway
GO:0060260 regulation of transcription initiation from RNA polymerase II promoter
GO:0060261 positive regulation of transcription initiation from RNA polymerase II promoter
GO:0061630 ubiquitin protein ligase activity
GO:0090245 axis elongation involved in somitogenesis
GO:1990403 embryonic brain development

Subcellular Location

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Subcellular Location
Nucleus

Domains

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DomainNameCategoryType
IPR019035 Mediator complex, subunit Med12DomainDomain
IPR021989 Mediator complex, subunit Med12, catenin-bindingDomainDomain
IPR021990 Mediator complex, subunit Med12, LCEWAV-domainDomainDomain

Diseases

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Interactions

56 interactions

InteractorPartnerSourcesPublicationsLink
MED12_HUMANMED29_HUMANBioGRID, IntAct15175163 15989967 20133760 22939629 24981860 26496610 details
MED12_HUMANESR2_HUMANBioGRID, IntAct11867769 21182203 details
MED12_HUMANA4_HUMANMINT21293490 details
MED12_HUMANAPLP1_HUMANMINT21293490 details
MED12_HUMANAPLP2_HUMANMINT21293490 details
MED12_HUMANMED18_HUMANBioGRID, IntAct, MINT15989967 20133760 24981860 26344197 26496610 28514442 details
MED12_HUMANESR1_HUMANBioGRID, IntAct11867769 26487511 31527615 details
MED12_HUMANMED28_HUMANBioGRID15175163 15989967 20133760 24981860 details
MED12_HUMANPRGC1_HUMANBioGRID14636573 details
MED12_HUMANVDR_HUMANBioGRID10198638 10235266 details
MED12_HUMANSOX9_HUMANBioGRID, HPRD12136106 details
MED12_HUMANLYST_HUMANBioGRID, HPRD11984006 details
MED12_HUMANNANOG_HUMANBioGRID19036726 details
MED12_HUMANGLI3_HUMANBioGRID17000779 details
MED12_HUMANEHMT2_HUMANBioGRID18691967 details
MED12_HUMANSRBP1_HUMANBioGRID10235267 11834832 16799563 details
MED12_HUMANMED10_HUMANBioGRID, DIP, IntAct10882111 14576168 15175163 15989967 17404243 20133760 24981860 26344197 26496610 details
MED12_HUMANMED26_HUMANBioGRID, HPRD, IntAct15175163 21729782 23563140 24981860 details
MED12_HUMANMED19_HUMANBioGRID, IntAct14576168 15175163 21729782 23563140 24981860 26186194 26344197 28514442 details
MED12_HUMANCDK19_HUMANBioGRID, IntAct, MINT15175163 20133760 23602568 23746844 23749998 24981860 26186194 26496610 28514442 30099503 details
MED12_HUMANMED4_HUMANBioGRID, IntAct, MINT20133760 21293490 22939629 24981860 25281560 26344197 26496610 details
MED12_HUMANCDK8_HUMANBioGRID, DIP, HPRD, IntAct, MINT10198638 10882111 11867769 15175163 19047373 20098423 20720539 23322298 23602568 23746844 23749998 24981860 26186194 26496610 27684187 28514442 29568061 30099503 30695077 details
MED12_HUMANTGFR2_HUMANIntAct23178117 details
MED12_HUMANCCNC_HUMANBioGRID, IntAct, MINT19047373 20133760 24981860 26186194 28514442 30099503 details
MED12_HUMANMED30_HUMANBioGRID, IntAct, MINT15989967 18691967 20133760 24981860 26496610 30099503 details
MED12_HUMANMED1_HUMANBioGRID, DIP, HPRD, IntAct15175163 15989967 20098423 20133760 23322298 23563140 24981860 26344197 26496610 27684187 28514442 details
MED12_HUMANMED24_HUMANBioGRID, IntAct20133760 22939629 24981860 26496610 details
MED12_HUMANMED8_HUMANBioGRID, HPRD, IntAct12584197 20133760 22939629 24981860 26344197 26496610 27684187 details
MED12_HUMANMED20_HUMANBioGRID, IntAct, MINT20133760 24981860 25281560 26496610 27684187 details
MED12_HUMANMED27_HUMANBioGRID, IntAct20133760 22939629 24981860 26344197 26496610 27684187 details
MED12_HUMANMED13_HUMANBioGRID, HPRD, IntAct15175163 20133760 24981860 26344197 26496610 27684187 29568061 details
MED12_HUMANMED11_HUMANBioGRID, IntAct20133760 22939629 24981860 26496610 details
MED12_HUMANMED16_HUMANBioGRID, IntAct20133760 22939629 24981860 26344197 26496610 details
MED12_HUMANMED23_HUMANBioGRID, IntAct, MINT20133760 25281560 26496610 30099503 details
MED12_HUMANMED6_HUMANBioGRID, IntAct20133760 22939629 24981860 26344197 26496610 27684187 details
MED12_HUMANMED31_HUMANBioGRID, IntAct, MINT20133760 24981860 26496610 details
MED12_HUMANMED14_HUMANBioGRID, IntAct20133760 23563140 24981860 26344197 26496610 27684187 details
MED12_HUMANMED21_HUMANBioGRID, IntAct, MINT20133760 22939629 24981860 26496610 28514442 details
MED12_HUMANMED25_HUMANBioGRID, IntAct14657022 20133760 26496610 details
MED12_HUMANMED15_HUMANBioGRID, IntAct14657022 20133760 24981860 26496610 details
MED12_HUMANMED17_HUMANBioGRID, IntAct20133760 24981860 26344197 26496610 details
MED12_HUMANTHA_HUMANBioGRID10198638 8710870 details
MED12_HUMANBRD4_HUMANBioGRID16109376 32416067 details
MED12_HUMANTRRAP_HUMANBioGRID18418385 details
MED12_HUMANSUPT3_HUMANBioGRID17967894 details
MED12_HUMANMED22_HUMANBioGRID20133760 24981860 26496610 details
MED12_HUMANRCOR1_HUMANBioGRID20133760 details
MED12_HUMANRPAB1_HUMANBioGRID20133760 24981860 details
MED12_HUMANCDK9_HUMANBioGRID20133760 details
MED12_HUMANZC3HD_HUMANBioGRID20133760 details
MED12_HUMANTRIP4_HUMANBioGRID20133760 details
MED12_HUMANSTN1_HUMANBioGRID20133760 details
MED12_HUMANQKI_HUMANBioGRID20133760 details
MED12_HUMANPTEN_HUMANBioGRID15717329 details
MED12_HUMANFBXW7_HUMANBioGRID23322298 25720964 details
MED12_HUMANMED12_HUMANHPRD14638676 details