Entity Details

Primary name FERM2_HUMAN
Entity type UniProt
Source Source Link

Details

AccessionQ96AC1
EntryNameFERM2_HUMAN
FullNameFermitin family homolog 2
TaxID9606
Evidenceevidence at protein level
Length680
SequenceStatuscomplete
DateCreated2003-11-07
DateModified2021-06-02

Ontological Relatives

GenesFERMT2

GO terms

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GOName
GO:0001725 stress fiber
GO:0003779 actin binding
GO:0005178 integrin binding
GO:0005547 phosphatidylinositol-3,4,5-trisphosphate binding
GO:0005634 nucleus
GO:0005654 nucleoplasm
GO:0005737 cytoplasm
GO:0005829 cytosol
GO:0005886 plasma membrane
GO:0005912 adherens junction
GO:0005925 focal adhesion
GO:0005938 cell cortex
GO:0007155 cell adhesion
GO:0007160 cell-matrix adhesion
GO:0007179 transforming growth factor beta receptor signaling pathway
GO:0007229 integrin-mediated signaling pathway
GO:0008360 regulation of cell shape
GO:0009986 cell surface
GO:0010718 positive regulation of epithelial to mesenchymal transition
GO:0016055 Wnt signaling pathway
GO:0019901 protein kinase binding
GO:0022604 regulation of cell morphogenesis
GO:0030054 cell junction
GO:0030055 cell-substrate junction
GO:0030335 positive regulation of cell migration
GO:0031234 extrinsic component of cytoplasmic side of plasma membrane
GO:0031258 lamellipodium membrane
GO:0031674 I band
GO:0033622 integrin activation
GO:0033625 positive regulation of integrin activation
GO:0034329 cell junction assembly
GO:0034334 adherens junction maintenance
GO:0034446 substrate adhesion-dependent cell spreading
GO:0034713 type I transforming growth factor beta receptor binding
GO:0035505 positive regulation of myosin light chain kinase activity
GO:0043116 negative regulation of vascular permeability
GO:0043547 positive regulation of GTPase activity
GO:0045599 negative regulation of fat cell differentiation
GO:0045669 positive regulation of osteoblast differentiation
GO:0046332 SMAD binding
GO:0048041 focal adhesion assembly
GO:0051015 actin filament binding
GO:0051496 positive regulation of stress fiber assembly
GO:0051894 positive regulation of focal adhesion assembly
GO:0051897 positive regulation of protein kinase B signaling
GO:0060173 limb development
GO:0060548 negative regulation of cell death
GO:0070374 positive regulation of ERK1 and ERK2 cascade
GO:0072657 protein localization to membrane
GO:1900026 positive regulation of substrate adhesion-dependent cell spreading
GO:1900182 positive regulation of protein localization to nucleus
GO:1902414 protein localization to cell junction
GO:1902462 positive regulation of mesenchymal stem cell proliferation
GO:1903691 positive regulation of wound healing, spreading of epidermal cells

Subcellular Location

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Subcellular Location
Cell junction
Cell projection
Cell surface
Cytoplasm
Membrane
Nucleus

Domains

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DomainNameCategoryType
IPR001849 Pleckstrin homology domainDomainDomain
IPR011993 PH-like domain superfamilyFamilyHomologous superfamily
IPR019748 FERM central domainDomainDomain
IPR019749 Band 4.1 domainDomainDomain
IPR035963 FERM superfamily, second domainFamilyHomologous superfamily
IPR037837 Kindlin/fermitin, PH domainDomainDomain
IPR037843 Kindlin/fermitinFamilyFamily
IPR040790 Kindlin-2, N-terminalDomainDomain

Diseases

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