Entity Details

Primary name TERT_HUMAN
Entity type UniProt
Source Source Link

Details

AccessionO14746
EntryNameTERT_HUMAN
FullNameTelomerase reverse transcriptase
TaxID9606
Evidenceevidence at protein level
Length1132
SequenceStatuscomplete
DateCreated2000-05-30
DateModified2021-06-02

Ontological Relatives

GenesTERT

GO terms

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GOName
GO:0000049 tRNA binding
GO:0000333 telomerase catalytic core complex
GO:0000723 telomere maintenance
GO:0000781 chromosome, telomeric region
GO:0000783 nuclear telomere cap complex
GO:0001172 transcription, RNA-templated
GO:0001223 transcription coactivator binding
GO:0003677 DNA binding
GO:0003720 telomerase activity
GO:0003721 telomerase RNA reverse transcriptase activity
GO:0003723 RNA binding
GO:0003964 RNA-directed DNA polymerase activity
GO:0003968 RNA-directed 5'-3' RNA polymerase activity
GO:0005634 nucleus
GO:0005654 nucleoplasm
GO:0005697 telomerase holoenzyme complex
GO:0005730 nucleolus
GO:0005829 cytosol
GO:0005886 plasma membrane
GO:0006278 RNA-dependent DNA biosynthetic process
GO:0007004 telomere maintenance via telomerase
GO:0007005 mitochondrion organization
GO:0008022 protein C-terminus binding
GO:0010629 negative regulation of gene expression
GO:0016605 PML body
GO:0016607 nuclear speck
GO:0022616 DNA strand elongation
GO:0030177 positive regulation of Wnt signaling pathway
GO:0030422 production of siRNA involved in RNA interference
GO:0031379 RNA-directed RNA polymerase complex
GO:0031647 regulation of protein stability
GO:0032092 positive regulation of protein binding
GO:0042162 telomeric DNA binding
GO:0042635 positive regulation of hair cycle
GO:0042645 mitochondrial nucleoid
GO:0042802 identical protein binding
GO:0042803 protein homodimerization activity
GO:0043524 negative regulation of neuron apoptotic process
GO:0045766 positive regulation of angiogenesis
GO:0046326 positive regulation of glucose import
GO:0046686 response to cadmium ion
GO:0046872 metal ion binding
GO:0047485 protein N-terminus binding
GO:0051000 positive regulation of nitric-oxide synthase activity
GO:0051087 chaperone binding
GO:0062103 double-stranded RNA biosynthetic process
GO:0070034 telomerase RNA binding
GO:0070200 establishment of protein localization to telomere
GO:0071456 cellular response to hypoxia
GO:0071897 DNA biosynthetic process
GO:0090399 replicative senescence
GO:0098680 template-free RNA nucleotidyltransferase
GO:1900087 positive regulation of G1/S transition of mitotic cell cycle
GO:1902895 positive regulation of pri-miRNA transcription by RNA polymerase II
GO:1903620 positive regulation of transdifferentiation
GO:1903704 negative regulation of production of siRNA involved in RNA interference
GO:1903799 negative regulation of production of miRNAs involved in gene silencing by miRNA
GO:1904707 positive regulation of vascular associated smooth muscle cell proliferation
GO:1904751 positive regulation of protein localization to nucleolus
GO:1904754 positive regulation of vascular associated smooth muscle cell migration
GO:1904837 beta-catenin-TCF complex assembly
GO:1990572 TERT-RMRP complex
GO:2000352 negative regulation of endothelial cell apoptotic process
GO:2000648 positive regulation of stem cell proliferation
GO:2000773 negative regulation of cellular senescence
GO:2001240 negative regulation of extrinsic apoptotic signaling pathway in absence of ligand

Subcellular Location

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Subcellular Location
Chromosome
Cytoplasm
Nucleus

Domains

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DomainNameCategoryType
IPR000477 Reverse transcriptase domainDomainDomain
IPR003545 Telomerase reverse transcriptaseFamilyFamily
IPR021891 Telomerase ribonucleoprotein complex - RNA-binding domainDomainDomain
IPR043502 DNA/RNA polymerase superfamilyFamilyHomologous superfamily

Diseases

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Drugs

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DrugNameSourceType
DB00495 ZidovudineDrugbanksmall molecule
DB05036 Grn163lDrugbanksmall molecule
DB12747 TertomotideDrugbankbiotech

Interactions

104 interactions

InteractorPartnerSourcesPublicationsLink
TERT_HUMANRUVB1_HUMANBioGRID, HPRD, IntAct18358808 details
TERT_HUMANAKT1_HUMANBioGRID, HPRD, MINT10224060 15843522 18775701 28205554 details
TERT_HUMANSMG5_HUMANbhf-ucl, BioGRID, HPRD12699629 details
TERT_HUMANEST1A_HUMANbhf-ucl, BioGRID, HPRD12699629 22011238 details
TERT_HUMANPINX1_HUMANbhf-ucl, BioGRID, HPRD, UniProt11701125 15381700 28255170 details
TERT_HUMANSMCA4_HUMANDIP, MINT19571879 24550003 details
TERT_HUMANTPP1_HUMANBioGRID, DIP, HPRD17237767 25172512 details
TERT_HUMANTERT_HUMANDIP, HPRD11029039 11751869 23474713 details
TERT_HUMANNUCL_HUMANBioGRID, HPRD15371412 details
TERT_HUMANMCRS1_HUMANBioGRID, HPRD15044100 details
TERT_HUMANHS90A_HUMANBioGRID, HPRD10197982 11274138 12586360 15843522 19751963 20959453 details
TERT_HUMANXRCC5_HUMANBioGRID, HPRD12377759 21855630 details
TERT_HUMANXRCC6_HUMANBioGRID, HPRD12377759 details
TERT_HUMAN1433Z_HUMANBioGRID10835362 details
TERT_HUMAN1433T_HUMANBioGRID, HPRD10835362 details
TERT_HUMANMDM2_HUMANBioGRID20453884 26370108 details
TERT_HUMANTERF1_HUMANBioGRID19487455 details
TERT_HUMANTEBP_HUMANBioGRID, HPRD10197982 11274138 19751963 20959453 details
TERT_HUMANCIB1_HUMANBioGRID, HPRD15190070 20959453 details
TERT_HUMANCHIP_HUMANBioGRID20959453 details
TERT_HUMANDYRK2_HUMANBioGRID23362280 details
TERT_HUMANXCT_HUMANBioGRID23741361 details
TERT_HUMANUB2D3_HUMANBioGRID23741361 details
TERT_HUMANSR140_HUMANBioGRID23741361 details
TERT_HUMANIREB2_HUMANBioGRID23741361 details
TERT_HUMANTGFR2_HUMANBioGRID23741361 details
TERT_HUMANAGAL_HUMANBioGRID23741361 details
TERT_HUMANPAIRB_HUMANBioGRID23741361 details
TERT_HUMANDYL1_HUMANBioGRID23741361 details
TERT_HUMANP20L1_HUMANBioGRID23741361 details
TERT_HUMANATPB_HUMANBioGRID23741361 details
TERT_HUMANFAP24_HUMANBioGRID23741361 details
TERT_HUMANPFD1_HUMANBioGRID23741361 details
TERT_HUMANTCPE_HUMANBioGRID23741361 details
TERT_HUMANIF2A_HUMANBioGRID23741361 details
TERT_HUMANTIM21_HUMANBioGRID23741361 details
TERT_HUMANTBA1B_HUMANBioGRID23741361 details
TERT_HUMANPABP1_HUMANBioGRID23741361 details
TERT_HUMANANXA2_HUMANBioGRID23741361 details
TERT_HUMANDDX51_HUMANBioGRID23741361 details
TERT_HUMANTOPK_HUMANBioGRID23741361 details
TERT_HUMANSTEA4_HUMANBioGRID23741361 details
TERT_HUMANTHIM_HUMANBioGRID23741361 details
TERT_HUMANENOA_HUMANBioGRID23741361 details
TERT_HUMANPPIA_HUMANBioGRID23741361 details
TERT_HUMANHSP74_HUMANBioGRID11274138 details
TERT_HUMANFOXO3_HUMANBioGRID26370108 details
TERT_HUMANFZR1_HUMANBioGRID28205554 details
TERT_HUMANMYC_HUMANBioGRID28205554 32140074 details
TERT_HUMANMERL_HUMANBioGRID28205554 details
TERT_HUMANBECN1_HUMANBioGRID28205554 details
TERT_HUMANBRAF_HUMANBioGRID28205554 details
TERT_HUMANCBLC_HUMANBioGRID28205554 details
TERT_HUMANCCND2_HUMANBioGRID28205554 details
TERT_HUMANCDK4_HUMANBioGRID28205554 details
TERT_HUMANCDK6_HUMANBioGRID28205554 details
TERT_HUMANCDN2A_HUMANBioGRID28205554 details
TERT_HUMANARF_HUMANBioGRID28205554 details
TERT_HUMANDACH1_HUMANBioGRID28205554 details
TERT_HUMANGLIS2_HUMANBioGRID28205554 details
TERT_HUMANGRM1_HUMANBioGRID28205554 details
TERT_HUMANMP2K5_HUMANBioGRID28205554 details
TERT_HUMANM3K5_HUMANBioGRID28205554 details
TERT_HUMANMET_HUMANBioGRID28205554 details
TERT_HUMANPGFRA_HUMANBioGRID28205554 details
TERT_HUMANRAF1_HUMANBioGRID28205554 details
TERT_HUMANRASF1_HUMANBioGRID28205554 details
TERT_HUMANSOX3_HUMANBioGRID28205554 details
TERT_HUMANSOX4_HUMANBioGRID28205554 details
TERT_HUMANCCNE1_HUMANBioGRID28205554 details
TERT_HUMANCDN2B_HUMANBioGRID28205554 details
TERT_HUMANFGFR4_HUMANBioGRID28205554 details
TERT_HUMANMP2K3_HUMANBioGRID28205554 details
TERT_HUMANSTK11_HUMANBioGRID28205554 details
TERT_HUMANTEAD2_HUMANBioGRID28205554 details
TERT_HUMANNSD3_HUMANBioGRID28205554 details
TERT_HUMANXPO1_HUMANHPRD10835362 details
TERT_HUMANRUVB2_HUMANBioGRID, HPRD, IntAct18358808 details
TERT_HUMANRENT1_HUMANMINT21829167 details
TERT_HUMANPML_HUMANbhf-ucl, BioGRID19567472 details
TERT_HUMANTERF2_HUMANMINT24550003 details
TERT_HUMANCOIL_HUMANMINT24550003 details
TERT_HUMANGNL3_HUMANMINT24550003 details
TERT_HUMANAGO2_HUMANMINT24550003 details
TERT_HUMANCTNB1_HUMANDIP19571879 details
TERT_HUMANACD_HUMANDIP23103865 details
TERT_HUMANNPM_HUMANUniProt28255170 details
TERT_HUMANTEP1_HUMANBioGRID, HPRD11029039 9389643 details
TERT_HUMANTF65_HUMANBioGRID, HPRD12517770 details
TERT_HUMANMTOR_HUMANBioGRID, HPRD15843522 details
TERT_HUMANKS6B1_HUMANBioGRID, HPRD15843522 details
TERT_HUMANMKRN1_HUMANBioGRID15805468 details
TERT_HUMANNAT10_HUMANBioGRID18082603 details
TERT_HUMANGNL3L_HUMANBioGRID19487455 details
TERT_HUMANPOTE1_HUMANBioGRID21855630 details
TERT_HUMANHS71A_HUMANBioGRID20959453 details
TERT_HUMANHS71B_HUMANBioGRID20959453 details
TERT_HUMANUBR5_HUMANBioGRID23362280 details
TERT_HUMANDDB1_HUMANBioGRID23362280 details
TERT_HUMANDCAF1_HUMANBioGRID23362280 23612978 details
TERT_HUMANDAXX_HUMANBioGRID25416818 details
TERT_HUMANKPCA_HUMANHPRD9837921 details
TERT_HUMANSRC_HUMANHPRD12808100 details
TERT_HUMANABL1_HUMANHPRD10837221 details