Entity Details

Primary name HMCN1_HUMAN
Entity type UniProt
Source Source Link

Details

AccessionQ96RW7
EntryNameHMCN1_HUMAN
FullNameHemicentin-1
TaxID9606
Evidenceevidence at protein level
Length5635
SequenceStatuscomplete
DateCreated2006-01-10
DateModified2021-06-02

Ontological Relatives

GenesHMCN1

GO terms

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GOName
GO:0005201 extracellular matrix structural constituent
GO:0005509 calcium ion binding
GO:0005604 basement membrane
GO:0005912 adherens junction
GO:0005938 cell cortex
GO:0007049 cell cycle
GO:0007156 homophilic cell adhesion via plasma membrane adhesion molecules
GO:0007157 heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules
GO:0007601 visual perception
GO:0009617 response to bacterium
GO:0032154 cleavage furrow
GO:0051301 cell division
GO:0062023 collagen-containing extracellular matrix
GO:0070062 extracellular exosome

Subcellular Location

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Subcellular Location
Cell junction
Cleavage furrow
Cytoplasm
Secreted

Domains

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DomainNameCategoryType
IPR000152 EGF-type aspartate/asparagine hydroxylation sitePTMPTM
IPR000742 EGF-like domainDomainDomain
IPR000884 Thrombospondin type-1 (TSP1) repeatRepeatRepeat
IPR001881 EGF-like calcium-binding domainDomainDomain
IPR003598 Immunoglobulin subtype 2DomainDomain
IPR003599 Immunoglobulin subtypeDomainDomain
IPR006605 G2 nidogen/fibulin G2FDomainDomain
IPR007110 Immunoglobulin-like domainDomainDomain
IPR009017 Green fluorescent proteinFamilyHomologous superfamily
IPR009030 Growth factor receptor cysteine-rich domain superfamilyFamilyHomologous superfamily
IPR013098 Immunoglobulin I-setDomainDomain
IPR013106 Immunoglobulin V-set domainDomainDomain
IPR013783 Immunoglobulin-like foldFamilyHomologous superfamily
IPR018097 EGF-like calcium-binding, conserved siteSiteConserved site
IPR026823 Complement Clr-like EGF domainDomainDomain
IPR036179 Immunoglobulin-like domain superfamilyFamilyHomologous superfamily
IPR036383 Thrombospondin type-1 (TSP1) repeat superfamilyFamilyHomologous superfamily
IPR036465 von Willebrand factor A-like domain superfamilyFamilyHomologous superfamily

Diseases

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Disease IDSourceNameDescription
603075 OMIMMacular degeneration, age-related, 1 (ARMD1)A form of age-related macular degeneration, a multifactorial eye disease and the most common cause of irreversible vision loss in the developed world. In most patients, the disease is manifest as ophthalmoscopically visible yellowish accumulations of protein and lipid that lie beneath the retinal pigment epithelium and within an elastin-containing structure known as Bruch membrane. The disease is caused by variants affecting the gene represented in this entry.

Interactions

1 interaction

InteractorPartnerSourcesPublicationsLink
HMCN1_HUMANARMS2_HUMANIntAct19696174 details