Entity Details

Primary name P2RX4_HUMAN
Entity type UniProt
Source Source Link

Details

AccessionQ99571
EntryNameP2RX4_HUMAN
FullNameP2X purinoceptor 4
TaxID9606
Evidenceevidence at protein level
Length388
SequenceStatuscomplete
DateCreated1997-11-01
DateModified2021-06-02

Ontological Relatives

GenesP2RX4

GO terms

Show/Hide Table
GOName
GO:0001614 purinergic nucleotide receptor activity
GO:0001894 tissue homeostasis
GO:0002028 regulation of sodium ion transport
GO:0002931 response to ischemia
GO:0004931 extracellularly ATP-gated cation channel activity
GO:0005102 signaling receptor binding
GO:0005507 copper ion binding
GO:0005524 ATP binding
GO:0005639 integral component of nuclear inner membrane
GO:0005765 lysosomal membrane
GO:0005886 plasma membrane
GO:0005887 integral component of plasma membrane
GO:0007165 signal transduction
GO:0007596 blood coagulation
GO:0008217 regulation of blood pressure
GO:0008270 zinc ion binding
GO:0010524 positive regulation of calcium ion transport into cytosol
GO:0010614 negative regulation of cardiac muscle hypertrophy
GO:0014069 postsynaptic density
GO:0016020 membrane
GO:0019228 neuronal action potential
GO:0019233 sensory perception of pain
GO:0019722 calcium-mediated signaling
GO:0030054 cell junction
GO:0032308 positive regulation of prostaglandin secretion
GO:0033198 response to ATP
GO:0034220 ion transmembrane transport
GO:0034405 response to fluid shear stress
GO:0035590 purinergic nucleotide receptor signaling pathway
GO:0042118 endothelial cell activation
GO:0042802 identical protein binding
GO:0043025 neuronal cell body
GO:0043195 terminal bouton
GO:0043197 dendritic spine
GO:0043536 positive regulation of blood vessel endothelial cell migration
GO:0044297 cell body
GO:0045296 cadherin binding
GO:0045429 positive regulation of nitric oxide biosynthetic process
GO:0048266 behavioral response to pain
GO:0048471 perinuclear region of cytoplasm
GO:0048678 response to axon injury
GO:0050850 positive regulation of calcium-mediated signaling
GO:0050920 regulation of chemotaxis
GO:0050975 sensory perception of touch
GO:0051897 positive regulation of protein kinase B signaling
GO:0051899 membrane depolarization
GO:0051928 positive regulation of calcium ion transport
GO:0055117 regulation of cardiac muscle contraction
GO:0055119 relaxation of cardiac muscle
GO:0070062 extracellular exosome
GO:0070588 calcium ion transmembrane transport
GO:0071294 cellular response to zinc ion
GO:0071318 cellular response to ATP
GO:0097190 apoptotic signaling pathway
GO:0099604 ligand-gated calcium channel activity
GO:1904124 microglial cell migration
GO:1904141 positive regulation of microglial cell migration
GO:2001028 positive regulation of endothelial cell chemotaxis

Subcellular Location

Show/Hide Table
Subcellular Location
Membrane

Domains

Show/Hide Table
DomainNameCategoryType
IPR001429 P2X purinoreceptorFamilyFamily
IPR003047 P2X4 purinoceptorFamilyFamily
IPR027309 P2X purinoreceptor extracellular domain superfamilyFamilyHomologous superfamily

Diseases

Show/Hide Table

Drugs

Show/Hide Table
DrugNameSourceType
DB01069 PromethazineDrugbanksmall molecule
DB09119 Eslicarbazepine acetateDrugbanksmall molecule
DB14575 EslicarbazepineDrugbanksmall molecule