Entity Details

Primary name ABCA3_HUMAN
Entity type UniProt
Source Source Link

Details

AccessionQ99758
EntryNameABCA3_HUMAN
FullNamePhospholipid-transporting ATPase ABCA3
TaxID9606
Evidenceevidence at protein level
Length1704
SequenceStatuscomplete
DateCreated2000-05-30
DateModified2021-06-02

Ontological Relatives

GenesABCA3

GO terms

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GOName
GO:0005319 lipid transporter activity
GO:0005524 ATP binding
GO:0005615 extracellular space
GO:0005765 lysosomal membrane
GO:0005770 late endosome
GO:0005886 plasma membrane
GO:0006855 drug transmembrane transport
GO:0006869 lipid transport
GO:0008559 ABC-type xenobiotic transporter activity
GO:0010875 positive regulation of cholesterol efflux
GO:0015914 phospholipid transport
GO:0016021 integral component of membrane
GO:0016887 ATP hydrolysis activity
GO:0030324 lung development
GO:0030659 cytoplasmic vesicle membrane
GO:0032464 positive regulation of protein homooligomerization
GO:0032585 multivesicular body membrane
GO:0042493 response to drug
GO:0042599 lamellar body
GO:0042626 ATPase-coupled transmembrane transporter activity
GO:0042908 xenobiotic transport
GO:0043129 surfactant homeostasis
GO:0043231 intracellular membrane-bounded organelle
GO:0044267 cellular protein metabolic process
GO:0046470 phosphatidylcholine metabolic process
GO:0046471 phosphatidylglycerol metabolic process
GO:0046618 drug export
GO:0046890 regulation of lipid biosynthetic process
GO:0051384 response to glucocorticoid
GO:0055091 phospholipid homeostasis
GO:0070925 organelle assembly
GO:0097208 alveolar lamellar body
GO:0097232 lamellar body membrane
GO:0097233 alveolar lamellar body membrane
GO:0120019 phosphatidylcholine transfer activity
GO:0140345 phosphatidylcholine flippase activity
GO:0150172 regulation of phosphatidylcholine metabolic process
GO:1902995 positive regulation of phospholipid efflux
GO:2001140 positive regulation of phospholipid transport

Subcellular Location

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Subcellular Location
Cytoplasmic vesicle membrane
Endosome
Late endosome membrane
Lysosome membrane

Domains

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DomainNameCategoryType
IPR003439 ABC transporter-like, ATP-binding domainDomainDomain
IPR003593 AAA+ ATPase domainDomainDomain
IPR017871 ABC transporter-like, conserved siteSiteConserved site
IPR026082 ABC transporter AFamilyFamily
IPR027417 P-loop containing nucleoside triphosphate hydrolaseFamilyHomologous superfamily

Diseases

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Drugs

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DrugNameSourceType
DB00619 ImatinibDrugbanksmall molecule

Interactions

4 interactions