Entity Details

Primary name M3K3_HUMAN
Entity type UniProt
Source Source Link

Details

AccessionQ99759
EntryNameM3K3_HUMAN
FullNameMitogen-activated protein kinase kinase kinase 3
TaxID9606
Evidenceevidence at protein level
Length626
SequenceStatuscomplete
DateCreated1997-11-01
DateModified2021-06-02

Ontological Relatives

GenesMAP3K3

GO terms

Show/Hide Table
GOName
GO:0000165 MAPK cascade
GO:0001568 blood vessel development
GO:0004672 protein kinase activity
GO:0004709 MAP kinase kinase kinase activity
GO:0005524 ATP binding
GO:0005829 cytosol
GO:0035556 intracellular signal transduction
GO:0043123 positive regulation of I-kappaB kinase/NF-kappaB signaling
GO:0046777 protein autophosphorylation
GO:0046872 metal ion binding
GO:0070498 interleukin-1-mediated signaling pathway
GO:0071864 positive regulation of cell proliferation in bone marrow
GO:0090050 positive regulation of cell migration involved in sprouting angiogenesis
GO:0106310 protein serine kinase activity
GO:0106311 protein threonine kinase activity
GO:1900745 positive regulation of p38MAPK cascade
GO:2000773 negative regulation of cellular senescence

Subcellular Location

Show/Hide Table

Domains

Show/Hide Table
DomainNameCategoryType
IPR000270 PB1 domainDomainDomain
IPR000719 Protein kinase domainDomainDomain
IPR011009 Protein kinase-like domain superfamilyFamilyHomologous superfamily
IPR034879 Mitogen-activated protein kinase kinase kinase 2/3, PB1 domainDomainDomain

Diseases

Show/Hide Table

Drugs

Show/Hide Table
DrugNameSourceType
DB12010 FostamatinibDrugbanksmall molecule

Interactions

190 interactions

InteractorPartnerSourcesPublicationsLink
M3K3_HUMANM3K2_HUMANBioGRID, IntAct14743216 24975362 26496610 details
M3K3_HUMANM3K3_HUMANBioGRID, HPRD, IntAct10593883 14743216 15001576 16407301 details
M3K3_HUMAN1433E_HUMANBioGRID, HPRD, IntAct, MINT12392720 14743216 16407301 9452471 details
M3K3_HUMANMP2K5_HUMANBioGRID, IntAct11073940 12813044 14743216 16861740 19903815 24975362 25241761 28514442 details
M3K3_HUMANZBT16_HUMANBioGRID, HPRD, IntAct16169070 details
M3K3_HUMAN2A5A_HUMANMINT16407301 details
M3K3_HUMAN2A5D_HUMANMINT16407301 details
M3K3_HUMANMK01_HUMANMINT16407301 details
M3K3_HUMANMK03_HUMANMINT16407301 details
M3K3_HUMANCSN5_HUMANBioGRID, IntAct20936779 details
M3K3_HUMANVWF_HUMANBioGRID, IntAct20936779 details
M3K3_HUMANGTF2I_HUMANBioGRID, IntAct21988832 details
M3K3_HUMANTM1L1_HUMANBioGRID, MINT21900206 details
M3K3_HUMANTRAF6_HUMANBioGRID, HPRD, IntAct14661019 19843958 19903815 25241761 details
M3K3_HUMANEGFR_HUMANBioGRID, IntAct24658140 25402006 31980649 details
M3K3_HUMANCCM2_HUMANDIP25982527 27027284 details
M3K3_HUMANGLRX3_HUMANBioGRID, IntAct25416956 29892012 details
M3K3_HUMANBRCA1_HUMANBioGRID, HPRD15205325 details
M3K3_HUMANGAB1_HUMANBioGRID, HPRD12065326 details
M3K3_HUMANSQSTM_HUMANBioGRID19843958 19903815 details
M3K3_HUMANNEDD4_HUMANBioGRID19953087 details
M3K3_HUMANNED4L_HUMANBioGRID19953087 details
M3K3_HUMANSMUF1_HUMANBioGRID19318350 details
M3K3_HUMANM3K7_HUMANBioGRID, HPRD16260783 19843958 details
M3K3_HUMANMP2K4_HUMANBioGRID25043814 9162092 details
M3K3_HUMANMP2K3_HUMANBioGRID9162092 details
M3K3_HUMANXIAP_HUMANBioGRID24975362 details
M3K3_HUMANBIRC2_HUMANBioGRID24975362 details
M3K3_HUMANMBP_HUMANBioGRID24975362 details
M3K3_HUMANMP2K7_HUMANBioGRID24975362 details
M3K3_HUMANGLI1_HUMANBioGRID29662197 details
M3K3_HUMANTRAF7_HUMANBioGRID, HPRD, IntAct14743216 15001576 details
M3K3_HUMANPFD1_HUMANIntAct14743216 details
M3K3_HUMANBAG2_HUMANIntAct14743216 details
M3K3_HUMANAIFM1_HUMANIntAct14743216 details
M3K3_HUMANRPAP3_HUMANIntAct14743216 details
M3K3_HUMANNEMO_HUMANIntAct14743216 details
M3K3_HUMANADSV_HUMANIntAct14743216 details
M3K3_HUMANHS71L_HUMANIntAct14743216 details
M3K3_HUMANTCPQ_HUMANIntAct14743216 details
M3K3_HUMANGBB2_HUMANIntAct14743216 details
M3K3_HUMANBIP_HUMANIntAct14743216 details
M3K3_HUMANDREB_HUMANIntAct14743216 details
M3K3_HUMANDNJB4_HUMANIntAct14743216 details
M3K3_HUMANTMOD3_HUMANIntAct14743216 details
M3K3_HUMANIKKA_HUMANBioGRID, IntAct14743216 25241761 details
M3K3_HUMANPFD6_HUMANIntAct14743216 details
M3K3_HUMANUBL4A_HUMANIntAct14743216 details
M3K3_HUMANCAZA1_HUMANIntAct14743216 details
M3K3_HUMANRS27L_HUMANIntAct14743216 details
M3K3_HUMANADT2_HUMANIntAct14743216 details
M3K3_HUMANHSP72_HUMANHPRD, IntAct1474216 14743216 details
M3K3_HUMANBAG5_HUMANIntAct14743216 details
M3K3_HUMANSYMC_HUMANIntAct14743216 details
M3K3_HUMANCOR1C_HUMANIntAct14743216 details
M3K3_HUMANRUVB2_HUMANIntAct14743216 details
M3K3_HUMANSGT1_HUMANIntAct14743216 details
M3K3_HUMANIQGA1_HUMANIntAct14743216 details
M3K3_HUMANRL23_HUMANIntAct14743216 details
M3K3_HUMANMYO1C_HUMANIntAct14743216 details
M3K3_HUMANHAX1_HUMANIntAct14743216 details
M3K3_HUMANTCPE_HUMANIntAct14743216 details
M3K3_HUMANEPIPL_HUMANIntAct14743216 details
M3K3_HUMANSERA_HUMANIntAct14743216 details
M3K3_HUMANCRCM_HUMANIntAct14743216 details
M3K3_HUMANHSP76_HUMANIntAct14743216 details
M3K3_HUMANDNJA1_HUMANIntAct14743216 details
M3K3_HUMANSYIC_HUMANIntAct14743216 details
M3K3_HUMANACTN4_HUMANIntAct14743216 details
M3K3_HUMANHNRH1_HUMANIntAct14743216 details
M3K3_HUMANMYO1B_HUMANIntAct14743216 details
M3K3_HUMANC1QBP_HUMANIntAct14743216 details
M3K3_HUMANEF1A2_HUMANIntAct14743216 details
M3K3_HUMANSCO2_HUMANIntAct14743216 details
M3K3_HUMANSPTN1_HUMANIntAct14743216 details
M3K3_HUMANPFD4_HUMANIntAct14743216 details
M3K3_HUMANDNJB1_HUMANIntAct14743216 details
M3K3_HUMANATPA_HUMANIntAct14743216 details
M3K3_HUMANMATR3_HUMANIntAct14743216 details
M3K3_HUMANTCPA_HUMANIntAct14743216 details
M3K3_HUMANTCPH_HUMANIntAct14743216 details
M3K3_HUMANTFG_HUMANIntAct14743216 details
M3K3_HUMANMYH10_HUMANIntAct14743216 details
M3K3_HUMANPYR1_HUMANIntAct14743216 details
M3K3_HUMANRUVB1_HUMANIntAct14743216 details
M3K3_HUMANACTG_HUMANIntAct14743216 details
M3K3_HUMANRMP_HUMANIntAct14743216 details
M3K3_HUMANTERA_HUMANIntAct14743216 details
M3K3_HUMANCNOT9_HUMANIntAct14743216 details
M3K3_HUMANTIM50_HUMANIntAct14743216 details
M3K3_HUMANCLH1_HUMANIntAct14743216 details
M3K3_HUMANIKKB_HUMANHPRD, IntAct11429546 14743216 details
M3K3_HUMANCHIP_HUMANIntAct14743216 details
M3K3_HUMAN2AAB_HUMANIntAct14743216 details
M3K3_HUMANGNAI2_HUMANIntAct14743216 details
M3K3_HUMANCAPZB_HUMANIntAct14743216 details
M3K3_HUMANGBB1_HUMANIntAct14743216 details
M3K3_HUMANFAS_HUMANIntAct14743216 details
M3K3_HUMANTCPG_HUMANIntAct14743216 details
M3K3_HUMANXPOT_HUMANIntAct14743216 details
M3K3_HUMANPLOD1_HUMANIntAct14743216 details
M3K3_HUMANPP1A_HUMANIntAct14743216 details
M3K3_HUMANTCPZ_HUMANIntAct14743216 details
M3K3_HUMANPFD5_HUMANIntAct14743216 details
M3K3_HUMANTBB2B_HUMANIntAct14743216 details
M3K3_HUMANF10A1_HUMANIntAct14743216 details
M3K3_HUMANTBB6_HUMANIntAct14743216 details
M3K3_HUMANHSP7C_HUMANIntAct14743216 details
M3K3_HUMANUBB_HUMANIntAct14743216 details
M3K3_HUMANNUDC_HUMANIntAct14743216 details
M3K3_HUMANMYO6_HUMANIntAct14743216 details
M3K3_HUMANCALM2_HUMANIntAct14743216 details
M3K3_HUMANRL40_HUMANIntAct14743216 details
M3K3_HUMANS10A8_HUMANIntAct14743216 details
M3K3_HUMAN2AAA_HUMANIntAct14743216 details
M3K3_HUMANPIHD1_HUMANIntAct14743216 details
M3K3_HUMANTBB5_HUMANIntAct14743216 details
M3K3_HUMANPFKAL_HUMANIntAct14743216 details
M3K3_HUMANRN126_HUMANIntAct14743216 details
M3K3_HUMANTBB4A_HUMANIntAct14743216 details
M3K3_HUMANCCAR2_HUMANIntAct14743216 details
M3K3_HUMANMPRIP_HUMANIntAct14743216 details
M3K3_HUMANSCRIB_HUMANIntAct14743216 details
M3K3_HUMANUXT_HUMANIntAct14743216 details
M3K3_HUMANUACA_HUMANIntAct14743216 details
M3K3_HUMANRAI14_HUMANIntAct14743216 details
M3K3_HUMANALK_HUMANIntAct14743216 details
M3K3_HUMANTBB3_HUMANIntAct14743216 details
M3K3_HUMANDNJA3_HUMANIntAct14743216 details
M3K3_HUMANRS27A_HUMANIntAct14743216 details
M3K3_HUMANFLNA_HUMANBioGRID, IntAct14743216 25241761 details
M3K3_HUMANMYPT1_HUMANIntAct14743216 details
M3K3_HUMANMYH9_HUMANIntAct14743216 details
M3K3_HUMANLYN_HUMANIntAct14743216 details
M3K3_HUMANTCPB_HUMANIntAct14743216 details
M3K3_HUMANSMRC2_HUMANIntAct14743216 details
M3K3_HUMANPFD3_HUMANIntAct14743216 details
M3K3_HUMANVIME_HUMANIntAct14743216 details
M3K3_HUMANH4_HUMANIntAct14743216 details
M3K3_HUMANSPTB2_HUMANIntAct14743216 details
M3K3_HUMANADT3_HUMANIntAct14743216 details
M3K3_HUMANLONM_HUMANIntAct14743216 details
M3K3_HUMANST134_HUMANIntAct14743216 details
M3K3_HUMANPYGM_HUMANIntAct14743216 details
M3K3_HUMANPP1G_HUMANIntAct14743216 details
M3K3_HUMANTBA3C_HUMANIntAct14743216 details
M3K3_HUMANTBA3D_HUMANIntAct14743216 details
M3K3_HUMANPRKDC_HUMANIntAct14743216 details
M3K3_HUMANMYL6_HUMANIntAct14743216 details
M3K3_HUMANDLG1_HUMANIntAct14743216 details
M3K3_HUMANDDB1_HUMANIntAct14743216 details
M3K3_HUMANG3P_HUMANIntAct14743216 details
M3K3_HUMANLEG7_HUMANIntAct14743216 details
M3K3_HUMANSC16A_HUMANIntAct14743216 details
M3K3_HUMANS10A7_HUMANIntAct14743216 details
M3K3_HUMANCOF2_HUMANIntAct14743216 details
M3K3_HUMANAKP8L_HUMANIntAct14743216 details
M3K3_HUMANCPVL_HUMANIntAct14743216 details
M3K3_HUMANDNJC7_HUMANIntAct14743216 details
M3K3_HUMANTCPD_HUMANIntAct14743216 details
M3K3_HUMANMYO1A_HUMANIntAct14743216 details
M3K3_HUMANLIMA1_HUMANIntAct14743216 details
M3K3_HUMANHS90B_HUMANHPRD, IntAct14743216 details
M3K3_HUMANML12A_HUMANIntAct14743216 details
M3K3_HUMANGNAI3_HUMANIntAct14743216 details
M3K3_HUMANIQGA2_HUMANIntAct14743216 details
M3K3_HUMANRS16_HUMANIntAct14743216 details
M3K3_HUMANRS27_HUMANIntAct14743216 details
M3K3_HUMANMYLK2_HUMANIntAct14743216 details
M3K3_HUMANMYO1D_HUMANIntAct14743216 details
M3K3_HUMANTBA1A_HUMANIntAct14743216 details
M3K3_HUMAN1433Z_HUMANHPRD, IntAct14743216 28514442 details
M3K3_HUMAN1433B_HUMANHPRD, IntAct, MINT14743216 18308725 28514442 details
M3K3_HUMAN1433F_HUMANHPRD, IntAct14743216 28514442 details
M3K3_HUMAN1433T_HUMANHPRD, IntAct14743216 28514442 details
M3K3_HUMANGRP75_HUMANIntAct14743216 details
M3K3_HUMANHS90A_HUMANBioGRID, HPRD, IntAct14743216 19560753 details
M3K3_HUMANKAPCA_HUMANBioGRID, HPRD, IntAct12392720 25241761 details
M3K3_HUMANCBY1_HUMANBioGRID, IntAct27173435 unassigned1312 details
M3K3_HUMANJIP4_HUMANBioGRID, HPRD12391307 details
M3K3_HUMANPP2AA_HUMANBioGRID20448038 details
M3K3_HUMANRIPK1_HUMANBioGRID, HPRD11429546 details
M3K3_HUMANIRAK1_HUMANBioGRID17197697 details
M3K3_HUMANNBR1_HUMANBioGRID25043814 details
M3K3_HUMANMTOR_HUMANBioGRID26279575 details
M3K3_HUMANSUFU_HUMANBioGRID29662197 details
M3K3_HUMANM3K5_HUMANHPRD12912994 details
M3K3_HUMANRCAN1_HUMANHPRD16126726 details
M3K3_HUMANIKBA_HUMANHPRD10085062 details
M3K3_HUMANWNK1_HUMANHPRD14681216 details