Entity Details

Primary name MYD88_HUMAN
Entity type UniProt
Source Source Link

Details

AccessionQ99836
EntryNameMYD88_HUMAN
FullNameMyeloid differentiation primary response protein MyD88
TaxID9606
Evidenceevidence at protein level
Length296
SequenceStatuscomplete
DateCreated2001-10-18
DateModified2021-06-02

Ontological Relatives

GenesMYD88

GO terms

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GOName
GO:0002224 toll-like receptor signaling pathway
GO:0002238 response to molecule of fungal origin
GO:0002269 leukocyte activation involved in inflammatory response
GO:0002283 neutrophil activation involved in immune response
GO:0002755 MyD88-dependent toll-like receptor signaling pathway
GO:0005121 Toll binding
GO:0005123 death receptor binding
GO:0005149 interleukin-1 receptor binding
GO:0005634 nucleus
GO:0005737 cytoplasm
GO:0005829 cytosol
GO:0005886 plasma membrane
GO:0006909 phagocytosis
GO:0006915 apoptotic process
GO:0007165 signal transduction
GO:0007166 cell surface receptor signaling pathway
GO:0007254 JNK cascade
GO:0008063 Toll signaling pathway
GO:0009615 response to virus
GO:0009682 induced systemic resistance
GO:0010008 endosome membrane
GO:0010628 positive regulation of gene expression
GO:0014069 postsynaptic density
GO:0016064 immunoglobulin mediated immune response
GO:0031663 lipopolysaccharide-mediated signaling pathway
GO:0032481 positive regulation of type I interferon production
GO:0032494 response to peptidoglycan
GO:0032722 positive regulation of chemokine production
GO:0032740 positive regulation of interleukin-17 production
GO:0032747 positive regulation of interleukin-23 production
GO:0032755 positive regulation of interleukin-6 production
GO:0032757 positive regulation of interleukin-8 production
GO:0032760 positive regulation of tumor necrosis factor production
GO:0032991 protein-containing complex
GO:0034162 toll-like receptor 9 signaling pathway
GO:0035325 Toll-like receptor binding
GO:0042742 defense response to bacterium
GO:0042802 identical protein binding
GO:0042832 defense response to protozoan
GO:0043066 negative regulation of apoptotic process
GO:0043123 positive regulation of I-kappaB kinase/NF-kappaB signaling
GO:0043621 protein self-association
GO:0045087 innate immune response
GO:0046330 positive regulation of JNK cascade
GO:0048661 positive regulation of smooth muscle cell proliferation
GO:0050671 positive regulation of lymphocyte proliferation
GO:0050727 regulation of inflammatory response
GO:0050830 defense response to Gram-positive bacterium
GO:0051092 positive regulation of NF-kappaB transcription factor activity
GO:0060337 type I interferon signaling pathway
GO:0070498 interleukin-1-mediated signaling pathway
GO:0070555 response to interleukin-1
GO:0070935 3'-UTR-mediated mRNA stabilization
GO:0070944 neutrophil-mediated killing of bacterium
GO:0070976 TIR domain binding
GO:0071222 cellular response to lipopolysaccharide
GO:0071260 cellular response to mechanical stimulus
GO:0090557 establishment of endothelial intestinal barrier
GO:0140052 cellular response to oxidised low-density lipoprotein particle stimulus
GO:1900017 positive regulation of cytokine production involved in inflammatory response
GO:1902622 regulation of neutrophil migration
GO:2000338 regulation of chemokine (C-X-C motif) ligand 1 production
GO:2000341 regulation of chemokine (C-X-C motif) ligand 2 production

Subcellular Location

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Subcellular Location
Cytoplasm
Nucleus

Domains

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DomainNameCategoryType
IPR000157 Toll/interleukin-1 receptor homology (TIR) domainDomainDomain
IPR000488 Death domainDomainDomain
IPR011029 Death-like domain superfamilyFamilyHomologous superfamily
IPR017281 Myeloid differentiation primary response protein MyD88FamilyFamily
IPR034249 MyD88, death domainDomainDomain
IPR035897 Toll/interleukin-1 receptor homology (TIR) domain superfamilyFamilyHomologous superfamily

Diseases

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Interactions

72 interactions

InteractorPartnerSourcesPublicationsLink
MYD88_HUMANIRAK4_HUMANBioGRID, DIP, HPRD, IntAct11960013 12538665 12860405 17548806 18221795 20485341 22011580 24316379 24735611 25416956 25502805 25910212 26871637 31515488 32296183 details
MYD88_HUMANFADD_HUMANBioGRID, HPRD, IntAct10880445 11828002 21988832 details
MYD88_HUMANTIRAP_HUMANBioGRID, DIP, HPRD, IntAct, MINT, UniProt11544529 17258210 17583698 18221795 20048342 21334391 24316379 28483816 details
MYD88_HUMANMYD88_HUMANBioGRID, DIP, HPIDb, HPRD, IntAct, MINT11544529 11909531 17258210 17548806 21516116 21988832 22155231 24316379 25416956 25910212 27107012 29892012 31930677 32296183 9575168 details
MYD88_HUMANSPOP_HUMANBioGRID, HPRD, IntAct16189514 21988832 26186194 28514442 31776466 details
MYD88_HUMANTLR2_HUMANBioGRID, HPRD, IntAct, MINT, UniProt15107846 16293622 16482509 17126326 29990310 details
MYD88_HUMANTLR4_HUMANBioGRID, HPRD, IntAct, MINT10952994 11743586 12646618 15107846 15728506 17126326 17258210 18221795 20048342 21829704 21911421 33052227 details
MYD88_HUMANTLR5_HUMANBioGRID, HPRD, MINT15107846 16482509 17583698 details
MYD88_HUMANSTAP2_HUMANBioGRID, HPRD, IntAct16365431 details
MYD88_HUMANTR13B_HUMANBioGRID, InnateDB20676093 details
MYD88_HUMANMDM2_HUMANBioGRID, IntAct21988832 details
MYD88_HUMANPRDX1_HUMANBioGRID, IntAct21988832 details
MYD88_HUMANPFKAL_HUMANBioGRID, IntAct21988832 details
MYD88_HUMANMBIP1_HUMANBioGRID, IntAct21988832 details
MYD88_HUMANSMAD3_HUMANBioGRID, IntAct21988832 details
MYD88_HUMANMAL_HUMANBioGRID, IntAct21988832 details
MYD88_HUMANTHIO_HUMANBioGRID, IntAct21988832 details
MYD88_HUMANSIAH2_HUMANBioGRID, IntAct21988832 details
MYD88_HUMANSIAH1_HUMANBioGRID, IntAct21988832 32117091 details
MYD88_HUMANUBP7_HUMANBioGRID, IntAct21988832 details
MYD88_HUMANRPAC1_HUMANBioGRID, IntAct21988832 details
MYD88_HUMANC1QR1_HUMANBioGRID, IntAct21988832 details
MYD88_HUMANTLR7_HUMANBioGRID, HPRD, IntAct16482509 21988832 details
MYD88_HUMANSARM1_HUMANBioGRID, IntAct17258210 26592460 details
MYD88_HUMANZNF35_HUMANBioGRID, IntAct32296183 details
MYD88_HUMANRNF4_HUMANBioGRID, IntAct32296183 details
MYD88_HUMANNTAQ1_HUMANBioGRID, IntAct32296183 details
MYD88_HUMANSPOPL_HUMANBioGRID, IntAct32296183 details
MYD88_HUMANTLR9_HUMANBioGRID15107846 21911421 details
MYD88_HUMANTLR3_HUMANBioGRID, HPRD12646618 details
MYD88_HUMANRAC1_HUMANBioGRID11416133 details
MYD88_HUMANIRF7_HUMANBioGRID, HPRD15361868 16484229 details
MYD88_HUMANCISH_HUMANBioGRID16961462 details
MYD88_HUMANIRF5_HUMANBioGRID, HPRD15665823 details
MYD88_HUMANNEMO_HUMANBioGRID23986494 details
MYD88_HUMANRN152_HUMANBioGRID31930677 details
MYD88_HUMANPELI2_HUMANHPRD12860405 details
MYD88_HUMANTLR8_HUMANHPRD16482509 details
MYD88_HUMANIRAK3_HUMANBioGRID, HPRD, MINT10383454 details
MYD88_HUMANIRAK1_HUMANBioGRID, DIP, HPIDb, HPRD, MINT10383454 10854325 11544529 11960013 11976320 12538665 16024789 16461741 16951688 17276401 17548806 17567694 17920759 21179087 21903422 22011580 31776466 33052227 details
MYD88_HUMANIRAK2_HUMANBioGRID, DIP, HPRD, MINT10383454 12659850 20485341 22011580 9374458 details
MYD88_HUMANILRL1_HUMANBioGRID, HPRD, UniProt15004556 16286016 details
MYD88_HUMANTRAF6_HUMANBioGRID, InnateDB16517750 20676093 22011580 23381138 23831471 31243359 31268348 33052227 details
MYD88_HUMANDOCK8_HUMANInnateDB22581261 details
MYD88_HUMANFAK2_HUMANInnateDB22581261 details
MYD88_HUMANCYH2_HUMANBioGRID, DIP23143332 details
MYD88_HUMANTLR10_HUMANHPRD, IntAct15728506 details
MYD88_HUMANHDAC6_HUMANBioGRID, IntAct20837465 29281743 31268348 details
MYD88_HUMANIL1R1_HUMANBioGRID, HPRD10854325 12609980 12659850 22904187 24735611 9374458 9575168 details
MYD88_HUMANLRRF1_HUMANBioGRID19265123 details
MYD88_HUMANLRRF2_HUMANBioGRID19265123 details
MYD88_HUMANFLII_HUMANBioGRID, HPRD16424162 19265123 details
MYD88_HUMANSQSTM_HUMANBioGRID20837465 details
MYD88_HUMANCBLB_HUMANBioGRID20639876 details
MYD88_HUMANTNIP1_HUMANBioGRID22011580 details
MYD88_HUMANTRAF3_HUMANBioGRID22011580 details
MYD88_HUMANBTK_HUMANBioGRID, HPRD12724322 details
MYD88_HUMANPELI1_HUMANBioGRID16951688 details
MYD88_HUMANSMAD6_HUMANBioGRID21897371 details
MYD88_HUMANSMUF1_HUMANBioGRID21897371 details
MYD88_HUMANBST2_HUMANBioGRID23221546 details
MYD88_HUMANIKKE_HUMANBioGRID23453969 details
MYD88_HUMANSASH1_HUMANBioGRID23776175 details
MYD88_HUMANKSYK_HUMANBioGRID23962979 details
MYD88_HUMANIRF4_HUMANBioGRID, HPRD16236719 24670424 details
MYD88_HUMANCYLD_HUMANBioGRID26719415 details
MYD88_HUMANUBAP1_HUMANBioGRID28483816 details
MYD88_HUMANTS101_HUMANBioGRID28483816 details
MYD88_HUMANBCAP_HUMANBioGRID27909057 details
MYD88_HUMANATG5_HUMANBioGRID23831471 details
MYD88_HUMANBANK1_HUMANBioGRID31243359 details
MYD88_HUMANIL1AP_HUMANHPRD11880380 details