Entity Details

Primary name NPC1_HUMAN
Entity type UniProt
Source Source Link

Details

AccessionO15118
EntryNameNPC1_HUMAN
FullNameNPC intracellular cholesterol transporter 1
TaxID9606
Evidenceevidence at protein level
Length1278
SequenceStatuscomplete
DateCreated2000-05-30
DateModified2021-06-02

Ontological Relatives

GenesNPC1

GO terms

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GOName
GO:0001618 virus receptor activity
GO:0004888 transmembrane signaling receptor activity
GO:0005576 extracellular region
GO:0005635 nuclear envelope
GO:0005764 lysosome
GO:0005765 lysosomal membrane
GO:0005783 endoplasmic reticulum
GO:0005794 Golgi apparatus
GO:0005887 integral component of plasma membrane
GO:0006486 protein glycosylation
GO:0006897 endocytosis
GO:0006914 autophagy
GO:0007041 lysosomal transport
GO:0007628 adult walking behavior
GO:0008203 cholesterol metabolic process
GO:0008206 bile acid metabolic process
GO:0010467 gene expression
GO:0015248 sterol transporter activity
GO:0015485 cholesterol binding
GO:0016020 membrane
GO:0016021 integral component of membrane
GO:0016242 negative regulation of macroautophagy
GO:0030301 cholesterol transport
GO:0031579 membrane raft organization
GO:0031902 late endosome membrane
GO:0032367 intracellular cholesterol transport
GO:0033344 cholesterol efflux
GO:0034383 low-density lipoprotein particle clearance
GO:0038023 signaling receptor activity
GO:0042493 response to drug
GO:0042632 cholesterol homeostasis
GO:0045121 membrane raft
GO:0046686 response to cadmium ion
GO:0046718 viral entry into host cell
GO:0048471 perinuclear region of cytoplasm
GO:0060548 negative regulation of cell death
GO:0070062 extracellular exosome
GO:0071383 cellular response to steroid hormone stimulus
GO:0071404 cellular response to low-density lipoprotein particle stimulus
GO:0090150 establishment of protein localization to membrane
GO:1905103 integral component of lysosomal membrane

Subcellular Location

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Subcellular Location
Late endosome membrane
Lysosome membrane

Domains

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DomainNameCategoryType
IPR000731 Sterol-sensing domainDomainDomain
IPR003392 Protein patched/dispatchedFamilyFamily
IPR004765 NPC1-likeFamilyFamily
IPR032190 Niemann-Pick C1, N-terminalDomainDomain

Diseases

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