Entity Details

Primary name SHRPN_HUMAN
Entity type UniProt
Source Source Link

Details

AccessionQ9H0F6
EntryNameSHRPN_HUMAN
FullNameSharpin
TaxID9606
Evidenceevidence at protein level
Length387
SequenceStatuscomplete
DateCreated2007-03-20
DateModified2021-06-02

Ontological Relatives

GenesSHARPIN

GO terms

Show/Hide Table
GOName
GO:0000151 ubiquitin ligase complex
GO:0004842 ubiquitin-protein transferase activity
GO:0005829 cytosol
GO:0007005 mitochondrion organization
GO:0007249 I-kappaB kinase/NF-kappaB signaling
GO:0007420 brain development
GO:0010803 regulation of tumor necrosis factor-mediated signaling pathway
GO:0014069 postsynaptic density
GO:0030262 apoptotic nuclear changes
GO:0030425 dendrite
GO:0031424 keratinization
GO:0031593 polyubiquitin modification-dependent protein binding
GO:0042802 identical protein binding
GO:0043123 positive regulation of I-kappaB kinase/NF-kappaB signaling
GO:0043130 ubiquitin binding
GO:0043161 proteasome-mediated ubiquitin-dependent protein catabolic process
GO:0044877 protein-containing complex binding
GO:0046872 metal ion binding
GO:0050728 negative regulation of inflammatory response
GO:0071797 LUBAC complex
GO:0097039 protein linear polyubiquitination
GO:2000348 regulation of CD40 signaling pathway

Subcellular Location

Show/Hide Table
Subcellular Location
Cell junction
Cytoplasm

Domains

Show/Hide Table
DomainNameCategoryType
IPR001876 Zinc finger, RanBP2-typeDomainDomain
IPR011993 PH-like domain superfamilyFamilyHomologous superfamily
IPR026261 RanBP-type and C3HC4-type zinc finger-containing protein 1/SHARPINFamilyFamily
IPR029071 Ubiquitin-like domain superfamilyFamilyHomologous superfamily
IPR031912 Sharpin, PH domainDomainDomain
IPR036443 Zinc finger, RanBP2-type superfamilyFamilyHomologous superfamily

Diseases

Show/Hide Table

Interactions

50 interactions

InteractorPartnerSourcesPublicationsLink
SHRPN_HUMANTHIOM_HUMANBioGRID, IntAct21988832 details
SHRPN_HUMANITA2_HUMANBioGRID, IntAct21947080 28775156 details
SHRPN_HUMANITA5_HUMANBioGRID, IntAct21947080 26600301 details
SHRPN_HUMANNEMO_HUMANBioGRID, DIP, IntAct, MINT21455180 21709223 23032186 23986494 27893701 28249776 30561431 30913450 details
SHRPN_HUMANHOIL1_HUMANBioGRID, DIP, IntAct, MINT21455180 21455181 23032186 24726327 26670046 28978479 30561431 30804189 31067453 33329596 details
SHRPN_HUMANRNF31_HUMANBioGRID, DIP, InnateDB, IntAct, MINT21455180 21455181 22158122 22791023 23032186 23104095 23746843 24141947 24726327 26600301 26670046 27307491 27545878 27591049 28514442 28775156 28978479 30561431 30804189 31067453 32019898 32122970 33329596 details
SHRPN_HUMANAP2C_HUMANIntAct24835590 details
SHRPN_HUMANBKRB2_HUMANIntAct24211782 details
SHRPN_HUMANUBP54_HUMANBioGRID, IntAct32296183 details
SHRPN_HUMANKRA62_HUMANBioGRID, IntAct32296183 details
SHRPN_HUMANKRA71_HUMANBioGRID, IntAct32296183 details
SHRPN_HUMANPCH2_HUMANBioGRID, IntAct32296183 details
SHRPN_HUMANSHAN1_HUMANBioGRID, HPRD11178875 12753155 details
SHRPN_HUMANITA1_HUMANBioGRID21947080 details
SHRPN_HUMANSHAN2_HUMANBioGRID23897824 details
SHRPN_HUMANITAL_HUMANBioGRID24210817 26600301 details
SHRPN_HUMANITAM_HUMANBioGRID24210817 details
SHRPN_HUMANITAD_HUMANBioGRID24210817 details
SHRPN_HUMANITB2_HUMANBioGRID26600301 details
SHRPN_HUMANTRAF1_HUMANBioGRID25996949 27893701 details
SHRPN_HUMANUBC_HUMANBioGRID28190767 29694895 details
SHRPN_HUMANOTU1_HUMANBioGRID28244869 details
SHRPN_HUMANARP2_HUMANBioGRID28775156 details
SHRPN_HUMANARP3_HUMANBioGRID28775156 details
SHRPN_HUMANPPIL3_HUMANBioGRID30348973 details
SHRPN_HUMANITA2B_HUMANBioGRID30804189 details
SHRPN_HUMANZBT32_HUMANBioGRID32296183 details
SHRPN_HUMANITB1_HUMANIntAct21947080 details
SHRPN_HUMANIL1A_HUMANIntAct21947080 details
SHRPN_HUMANTNFA_HUMANBioGRID, DIP, InnateDB, IntAct, MINT23032186 23032187 23104095 23955153 26670046 27307491 27458237 27545878 27560715 30420664 30561431 31898971 details
SHRPN_HUMANMALT1_HUMANBioGRID, IntAct27070702 33329596 details
SHRPN_HUMANSHRPN_HUMANBioGRID, HPRD, IntAct11178875 28775156 30561431 details
SHRPN_HUMANNOD2_HUMANBioGRID, IntAct22607974 23818254 26670046 details
SHRPN_HUMANFMR1_HUMANMINT21653829 details
SHRPN_HUMANFXR1_HUMANMINT21653829 details
SHRPN_HUMANSHAN3_HUMANMINT21653829 details
SHRPN_HUMANPTEN_HUMANBioGRID20458142 25152374 details
SHRPN_HUMANOTUL_HUMANBioGRID23746843 24726323 26670046 27591049 28919039 details
SHRPN_HUMANTNR1A_HUMANBioGRID23746843 27552911 30420664 details
SHRPN_HUMANCYLD_HUMANBioGRID26670046 27591049 31067453 details
SHRPN_HUMANPDLI7_HUMANBioGRID27903798 details
SHRPN_HUMANTLR3_HUMANBioGRID27810922 details
SHRPN_HUMANMDM2_HUMANBioGRID28063307 details
SHRPN_HUMANSPAT2_HUMANBioGRID27307491 27591049 details
SHRPN_HUMANESR1_HUMANBioGRID29100376 details
SHRPN_HUMANANM5_HUMANBioGRID29227283 details
SHRPN_HUMANSKI_HUMANBioGRID29227283 details
SHRPN_HUMANUBP20_HUMANBioGRID30354204 details
SHRPN_HUMANHD_HUMANBioGRID30886048 details
SHRPN_HUMANCASP1_HUMANBioGRID32122970 details