Entity Details

Primary name ABCG8_HUMAN
Entity type UniProt
Source Source Link

Details

AccessionQ9H221
EntryNameABCG8_HUMAN
FullNameATP-binding cassette sub-family G member 8
TaxID9606
Evidenceevidence at protein level
Length673
SequenceStatuscomplete
DateCreated2001-12-05
DateModified2021-06-02

Ontological Relatives

GenesABCG8

GO terms

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GOName
GO:0005524 ATP binding
GO:0005886 plasma membrane
GO:0005887 integral component of plasma membrane
GO:0006869 lipid transport
GO:0007584 response to nutrient
GO:0007588 excretion
GO:0010949 negative regulation of intestinal phytosterol absorption
GO:0014850 response to muscle activity
GO:0015914 phospholipid transport
GO:0015918 sterol transport
GO:0016324 apical plasma membrane
GO:0030299 intestinal cholesterol absorption
GO:0030522 intracellular receptor signaling pathway
GO:0033344 cholesterol efflux
GO:0038183 bile acid signaling pathway
GO:0042493 response to drug
GO:0042626 ATPase-coupled transmembrane transporter activity
GO:0042632 cholesterol homeostasis
GO:0043190 ATP-binding cassette (ABC) transporter complex
GO:0043235 receptor complex
GO:0045796 negative regulation of intestinal cholesterol absorption
GO:0046872 metal ion binding
GO:0046982 protein heterodimerization activity
GO:0070328 triglyceride homeostasis
GO:0120020 cholesterol transfer activity

Subcellular Location

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Subcellular Location
Apical cell membrane
Cell membrane

Domains

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DomainNameCategoryType
IPR003439 ABC transporter-like, ATP-binding domainDomainDomain
IPR013525 ABC-2 type transporterDomainDomain
IPR017871 ABC transporter-like, conserved siteSiteConserved site
IPR027417 P-loop containing nucleoside triphosphate hydrolaseFamilyHomologous superfamily
IPR043926 ABC transporter family G domainDomainDomain

Diseases

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Drugs

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DrugNameSourceType
DB11635 TocofersolanDrugbanksmall molecule

Interactions

9 interactions