Entity Details

Primary name CHM4B_HUMAN
Entity type UniProt
Source Source Link

Details

AccessionQ9H444
EntryNameCHM4B_HUMAN
FullNameCharged multivesicular body protein 4b
TaxID9606
Evidenceevidence at protein level
Length224
SequenceStatuscomplete
DateCreated2002-11-01
DateModified2021-06-02

Ontological Relatives

GenesCHMP4B

GO terms

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GOName
GO:0000281 mitotic cytokinesis
GO:0000815 ESCRT III complex
GO:0005634 nucleus
GO:0005635 nuclear envelope
GO:0005737 cytoplasm
GO:0005768 endosome
GO:0005771 multivesicular body
GO:0005829 cytosol
GO:0006620 posttranslational protein targeting to endoplasmic reticulum membrane
GO:0006900 vesicle budding from membrane
GO:0006914 autophagy
GO:0006997 nucleus organization
GO:0007080 mitotic metaphase plate congression
GO:0007084 mitotic nuclear membrane reassembly
GO:0009898 cytoplasmic side of plasma membrane
GO:0010458 exit from mitosis
GO:0010824 regulation of centrosome duplication
GO:0016197 endosomal transport
GO:0016236 macroautophagy
GO:0019058 viral life cycle
GO:0030117 membrane coat
GO:0030496 midbody
GO:0031468 nuclear membrane reassembly
GO:0031902 late endosome membrane
GO:0031982 vesicle
GO:0032511 late endosome to vacuole transport via multivesicular body sorting pathway
GO:0036258 multivesicular body assembly
GO:0036438 maintenance of lens transparency
GO:0039702 viral budding via host ESCRT complex
GO:0042802 identical protein binding
GO:0042803 protein homodimerization activity
GO:0045296 cadherin binding
GO:0046755 viral budding
GO:0050792 regulation of viral process
GO:0051258 protein polymerization
GO:0060548 negative regulation of cell death
GO:0061952 midbody abscission
GO:0070062 extracellular exosome
GO:0090148 membrane fission
GO:0090611 ubiquitin-independent protein catabolic process via the multivesicular body sorting pathway
GO:1901215 negative regulation of neuron death
GO:1901673 regulation of mitotic spindle assembly
GO:1902188 positive regulation of viral release from host cell
GO:1902902 negative regulation of autophagosome assembly

Subcellular Location

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Subcellular Location
Cytoplasm
Late endosome membrane
Midbody
Nucleus envelope

Domains

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DomainNameCategoryType
IPR005024 Snf7 familyFamilyFamily

Diseases

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Disease IDSourceNameDescription
605387 OMIMCataract 31, multiple types (CTRCT31)An opacification of the crystalline lens of the eye that frequently results in visual impairment or blindness. Opacities vary in morphology, are often confined to a portion of the lens, and may be static or progressive. In general, the more posteriorly located and dense an opacity, the greater the impact on visual function. CTRCT31 includes posterior polar, progressive posterior subcapsular, nuclear, and anterior subcapsular cataracts. The disease is caused by variants affecting the gene represented in this entry.

Interactions

32 interactions

InteractorPartnerSourcesPublicationsLink
CHM4B_HUMANUBC9_HUMANBioGRID, HPRD, IntAct16189514 16730941 32296183 details
CHM4B_HUMANSTABP_HUMANBioGRID, HPRD, IntAct, UniProt16730941 17711858 details
CHM4B_HUMANUBP8_HUMANMINT19302785 details
CHM4B_HUMANUBP54_HUMANMINT19302785 details
CHM4B_HUMANPTN23_HUMANBioGRID, DIP, MINT17174262 18434552 26866605 details
CHM4B_HUMANHD_HUMANIntAct17500595 32814053 details
CHM4B_HUMANCHMP3_HUMANBioGRID, HPRD, IntAct14505570 16730941 23051622 26344197 26496610 details
CHM4B_HUMANC2D1A_HUMANBioGRID, IntAct16730941 26496610 31586073 details
CHM4B_HUMANCHM2A_HUMANBioGRID, IntAct23051622 26040713 26496610 details
CHM4B_HUMANCHMP5_HUMANBioGRID, HPRD, IntAct16730941 26344197 26496610 details
CHM4B_HUMANCHM1B_HUMANBioGRID, HPRD, IntAct16730941 26344197 26496610 31586073 details
CHM4B_HUMANPDC6I_HUMANBioGRID, DIP, HPRD, IntAct12860994 14505570 14678797 17174262 18434552 18511562 20929444 21889351 22484091 23895345 26490116 26496610 31586073 details
CHM4B_HUMANCHM2B_HUMANBioGRID, IntAct23051622 26344197 26496610 details
CHM4B_HUMANCHM4A_HUMANBioGRID, HPRD, IntAct16730941 32296183 details
CHM4B_HUMANCHM4B_HUMANBioGRID, DIP, HPRD, IntAct16730941 19523902 31586073 details
CHM4B_HUMANCHMP6_HUMANBioGRID, HPRD, IntAct14505570 15511219 16730941 details
CHM4B_HUMANVPS4A_HUMANBioGRID, HPRD, IntAct12860994 16730941 details
CHM4B_HUMANCHM4C_HUMANBioGRID, HPRD, IntAct14505570 16730941 31586073 details
CHM4B_HUMANPIAS2_HUMANBioGRID, HPRD, IntAct16730941 details
CHM4B_HUMANEXOS9_HUMANBioGRID, HPRD, IntAct16730941 details
CHM4B_HUMANHIPK2_HUMANBioGRID, HPRD, IntAct16730941 details
CHM4B_HUMANCHD3_HUMANIntAct16730941 details
CHM4B_HUMANCHMP7_HUMANIntAct16856878 details
CHM4B_HUMANPLIN3_HUMANBioGRID, IntAct32296183 details
CHM4B_HUMANBROX_HUMANBioGRID, DIP19403673 22484091 details
CHM4B_HUMANNOD2_HUMANBioGRID27812135 details
CHM4B_HUMANKAP0_HUMANIntAct20195357 details
CHM4B_HUMANNOLC1_HUMANBioGRID21264300 31586073 details
CHM4B_HUMANVATB1_HUMANBioGRID21674799 details
CHM4B_HUMANITA4_HUMANBioGRID22623428 details
CHM4B_HUMANBIN1_HUMANBioGRID28806752 details
CHM4B_HUMANSH3K1_HUMANBioGRID25005938 details