Entity Details

Primary name MRP5_HUMAN
Entity type UniProt
Source Source Link

Details

AccessionO15440
EntryNameMRP5_HUMAN
FullNameMultidrug resistance-associated protein 5
TaxID9606
Evidenceevidence at protein level
Length1437
SequenceStatuscomplete
DateCreated1998-07-15
DateModified2021-06-02

Ontological Relatives

GenesABCC5

GO terms

Show/Hide Table
GOName
GO:0005524 ATP binding
GO:0005796 Golgi lumen
GO:0005886 plasma membrane
GO:0005887 integral component of plasma membrane
GO:0008514 organic anion transmembrane transporter activity
GO:0008559 ABC-type xenobiotic transporter activity
GO:0010008 endosome membrane
GO:0015216 purine nucleotide transmembrane transporter activity
GO:0015232 heme transmembrane transporter activity
GO:0015562 efflux transmembrane transporter activity
GO:0015865 purine nucleotide transport
GO:0016020 membrane
GO:0016323 basolateral plasma membrane
GO:0016324 apical plasma membrane
GO:0030213 hyaluronan biosynthetic process
GO:0034634 glutathione transmembrane transporter activity
GO:0034775 glutathione transmembrane transport
GO:0035351 heme transmembrane transport
GO:0042626 ATPase-coupled transmembrane transporter activity
GO:0042908 xenobiotic transport
GO:0042910 xenobiotic transmembrane transporter activity
GO:0055085 transmembrane transport
GO:0070730 cAMP transport
GO:0070731 cGMP transport
GO:0098838 folate transmembrane transport
GO:0140115 export across plasma membrane
GO:0150104 transport across blood-brain barrier

Subcellular Location

Show/Hide Table
Subcellular Location
Basolateral cell membrane
Cytoplasmic granule
Endosome membrane
Golgi apparatus lumen

Domains

Show/Hide Table
DomainNameCategoryType
IPR003439 ABC transporter-like, ATP-binding domainDomainDomain
IPR003593 AAA+ ATPase domainDomainDomain
IPR011527 ABC transporter type 1, transmembrane domainDomainDomain
IPR017871 ABC transporter-like, conserved siteSiteConserved site
IPR027417 P-loop containing nucleoside triphosphate hydrolaseFamilyHomologous superfamily
IPR030238 Multidrug resistance-associated protein 5FamilyFamily
IPR036640 ABC transporter type 1, transmembrane domain superfamilyFamilyHomologous superfamily

Diseases

Show/Hide Table

Drugs

Show/Hide Table
DrugNameSourceType
DB00143 GlutathioneDrugbanksmall molecule
DB00203 SildenafilDrugbanksmall molecule
DB00495 ZidovudineDrugbanksmall molecule
DB00515 CisplatinDrugbanksmall molecule
DB00544 FluorouracilDrugbanksmall molecule
DB00718 Adefovir dipivoxilDrugbanksmall molecule
DB00770 AlprostadilDrugbanksmall molecule
DB00917 DinoprostoneDrugbanksmall molecule
DB00975 DipyridamoleDrugbanksmall molecule
DB01032 ProbenecidDrugbanksmall molecule
DB01033 MercaptopurineDrugbanksmall molecule
DB01045 RifampicinDrugbanksmall molecule
DB01076 AtorvastatinDrugbanksmall molecule
DB01138 SulfinpyrazoneDrugbanksmall molecule
DB02527 Cyclic adenosine monophosphateDrugbanksmall molecule
DB11672 CurcuminDrugbanksmall molecule
DB14635 Curcumin sulfateDrugbanksmall molecule

Interactions

4 interactions

InteractorPartnerSourcesPublicationsLink
MRP5_HUMANSMC2_HUMANBioGRID, IntAct21988832 details
MRP5_HUMANKAD2_HUMANBioGRID, IntAct21988832 details
MRP5_HUMANRET5_HUMANBioGRID, IntAct21988832 details
MRP5_HUMANAACT_HUMANBioGRID, IntAct21988832 details