Entity Details

Primary name MTD2L_HUMAN
Entity type UniProt
Source Source Link

Details

AccessionQ9H903
EntryNameMTD2L_HUMAN
FullNameProbable bifunctional methylenetetrahydrofolate dehydrogenase/cyclohydrolase 2
TaxID9606
Evidenceevidence at protein level
Length347
SequenceStatuscomplete
DateCreated2008-05-20
DateModified2021-06-02

Ontological Relatives

GenesMTHFD2L

GO terms

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GOName
GO:0000105 histidine biosynthetic process
GO:0004477 methenyltetrahydrofolate cyclohydrolase activity
GO:0004487 methylenetetrahydrofolate dehydrogenase (NAD+) activity
GO:0004488 methylenetetrahydrofolate dehydrogenase (NADP+) activity
GO:0005739 mitochondrion
GO:0005743 mitochondrial inner membrane
GO:0005759 mitochondrial matrix
GO:0006164 purine nucleotide biosynthetic process
GO:0009086 methionine biosynthetic process
GO:0009256 10-formyltetrahydrofolate metabolic process
GO:0035999 tetrahydrofolate interconversion
GO:0046655 folic acid metabolic process

Subcellular Location

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Subcellular Location
Mitochondrion inner membrane

Domains

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DomainNameCategoryType
IPR000672 Tetrahydrofolate dehydrogenase/cyclohydrolaseFamilyFamily
IPR020630 Tetrahydrofolate dehydrogenase/cyclohydrolase, catalytic domainDomainDomain
IPR020631 Tetrahydrofolate dehydrogenase/cyclohydrolase, NAD(P)-binding domainDomainDomain
IPR020867 Tetrahydrofolate dehydrogenase/cyclohydrolase, conserved siteSiteConserved site
IPR036291 NAD(P)-binding domain superfamilyFamilyHomologous superfamily

Diseases

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Interactions

1 interaction

InteractorPartnerSourcesPublicationsLink
MTD2L_HUMANNTAQ1_HUMANBioGRID, IntAct32296183 details