Entity Details

Primary name CLOCK_HUMAN
Entity type UniProt
Source Source Link

Details

AccessionO15516
EntryNameCLOCK_HUMAN
FullNameCircadian locomoter output cycles protein kaput
TaxID9606
Evidenceevidence at protein level
Length846
SequenceStatuscomplete
DateCreated1999-07-15
DateModified2021-06-02

Ontological Relatives

GenesCLOCK

GO terms

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GOName
GO:0000077 DNA damage checkpoint signaling
GO:0000785 chromatin
GO:0000978 RNA polymerase II cis-regulatory region sequence-specific DNA binding
GO:0000981 DNA-binding transcription factor activity, RNA polymerase II-specific
GO:0001228 DNA-binding transcription activator activity, RNA polymerase II-specific
GO:0003677 DNA binding
GO:0003700 DNA-binding transcription factor activity
GO:0004402 histone acetyltransferase activity
GO:0005634 nucleus
GO:0005654 nucleoplasm
GO:0005667 transcription regulator complex
GO:0005694 chromosome
GO:0005829 cytosol
GO:0006355 regulation of transcription, DNA-templated
GO:0006357 regulation of transcription by RNA polymerase II
GO:0006473 protein acetylation
GO:0007165 signal transduction
GO:0007283 spermatogenesis
GO:0007623 circadian rhythm
GO:0009648 photoperiodism
GO:0031490 chromatin DNA binding
GO:0032922 circadian regulation of gene expression
GO:0033391 chromatoid body
GO:0042634 regulation of hair cycle
GO:0042752 regulation of circadian rhythm
GO:0043161 proteasome-mediated ubiquitin-dependent protein catabolic process
GO:0043231 intracellular membrane-bounded organelle
GO:0043565 sequence-specific DNA binding
GO:0045892 negative regulation of transcription, DNA-templated
GO:0045893 positive regulation of transcription, DNA-templated
GO:0045944 positive regulation of transcription by RNA polymerase II
GO:0046983 protein dimerization activity
GO:0050729 positive regulation of inflammatory response
GO:0050796 regulation of insulin secretion
GO:0051092 positive regulation of NF-kappaB transcription factor activity
GO:0051775 response to redox state
GO:0070888 E-box binding
GO:0071479 cellular response to ionizing radiation
GO:1990513 CLOCK-BMAL transcription complex
GO:1990837 sequence-specific double-stranded DNA binding
GO:2000074 regulation of type B pancreatic cell development
GO:2000323 negative regulation of glucocorticoid receptor signaling pathway

Subcellular Location

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Subcellular Location
Cytoplasm
Nucleus

Domains

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DomainNameCategoryType
IPR000014 PAS domainDomainDomain
IPR001067 Nuclear translocatorFamilyFamily
IPR001610 PAC motifRepeatRepeat
IPR011598 Myc-type, basic helix-loop-helix (bHLH) domainDomainDomain
IPR013767 PAS foldDomainDomain
IPR035965 PAS domain superfamilyFamilyHomologous superfamily
IPR036638 Helix-loop-helix DNA-binding domain superfamilyFamilyHomologous superfamily

Diseases

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Interactions

61 interactions

InteractorPartnerSourcesPublicationsLink
CLOCK_HUMANBMAL1_HUMANBioGRID, HPRD, IntAct11018023 11439184 14701734 19922678 20551151 23555304 26164627 27173435 28388406 28514442 30287810 31515488 32296183 9576906 9989497 unassigned1312 details
CLOCK_HUMANBMAL2_HUMANBioGRID, HPRD, IntAct10864977 11018023 14701734 28514442 32296183 details
CLOCK_HUMANCIPC_HUMANBioGRID, IntAct23555304 26186194 28514442 details
CLOCK_HUMANCLOCK_HUMANDIP24737000 details
CLOCK_HUMANKMT2A_HUMANDIP25751424 details
CLOCK_HUMANCRY1_HUMANBioGRID, IntAct, MINT23555304 28388406 32538895 details
CLOCK_HUMANEP300_HUMANBioGRID14645221 details
CLOCK_HUMANKAT2B_HUMANBioGRID14645221 details
CLOCK_HUMANRXRA_HUMANBioGRID11439184 details
CLOCK_HUMANRARA_HUMANBioGRID11439184 details
CLOCK_HUMANSIR1_HUMANBioGRID18662547 details
CLOCK_HUMANCRY2_HUMANBioGRID23555304 31155351 details
CLOCK_HUMANBHE41_HUMANBioGRID23555304 details
CLOCK_HUMANNPAS2_HUMANBioGRID23555304 details
CLOCK_HUMAN2A5D_HUMANBioGRID23555304 details
CLOCK_HUMAN2A5E_HUMANBioGRID23555304 details
CLOCK_HUMANCSK2B_HUMANBioGRID23555304 details
CLOCK_HUMAN2AAB_HUMANBioGRID23555304 details
CLOCK_HUMANNR1D2_HUMANBioGRID23555304 details
CLOCK_HUMANPER2_HUMANBioGRID23555304 details
CLOCK_HUMANPP1A_HUMANBioGRID23555304 details
CLOCK_HUMANPP1B_HUMANBioGRID23555304 details
CLOCK_HUMANPP1G_HUMANBioGRID23555304 details
CLOCK_HUMANKC1E_HUMANBioGRID23555304 details
CLOCK_HUMANDBP_HUMANBioGRID23555304 details
CLOCK_HUMANRORG_HUMANBioGRID23555304 details
CLOCK_HUMANRHOA_HUMANBioGRID30287810 details
CLOCK_HUMANMAX_HUMANBioGRID, IntAct27173435 unassigned1312 details
CLOCK_HUMANYETS4_HUMANBioGRID, IntAct27173435 unassigned1312 details
CLOCK_HUMANKDM1A_HUMANBioGRID, IntAct27173435 unassigned1312 details
CLOCK_HUMANMS18B_HUMANBioGRID, IntAct27173435 unassigned1312 details
CLOCK_HUMANPSMD9_HUMANBioGRID, IntAct27173435 unassigned1312 details
CLOCK_HUMANRBG1L_HUMANBioGRID, IntAct27173435 unassigned1312 details
CLOCK_HUMANTFPT_HUMANBioGRID, IntAct27173435 unassigned1312 details
CLOCK_HUMANRCOR1_HUMANBioGRID, IntAct27173435 unassigned1312 details
CLOCK_HUMANVPS51_HUMANBioGRID, IntAct27173435 unassigned1312 details
CLOCK_HUMANHM20A_HUMANBioGRID, IntAct27173435 unassigned1312 details
CLOCK_HUMANTUFT1_HUMANBioGRID, IntAct27173435 unassigned1312 details
CLOCK_HUMANNCK5L_HUMANBioGRID, IntAct27173435 unassigned1312 details
CLOCK_HUMANNUF2_HUMANBioGRID, IntAct27173435 unassigned1312 details
CLOCK_HUMANTHA11_HUMANBioGRID, IntAct27173435 unassigned1312 details
CLOCK_HUMANPF21A_HUMANBioGRID, IntAct27173435 unassigned1312 details
CLOCK_HUMANCCHCR_HUMANBioGRID, IntAct27173435 unassigned1312 details
CLOCK_HUMANGOGA5_HUMANBioGRID, IntAct27173435 unassigned1312 details
CLOCK_HUMANDZIP3_HUMANBioGRID, IntAct27173435 unassigned1312 details
CLOCK_HUMANHAUS6_HUMANBioGRID, IntAct27173435 unassigned1312 details
CLOCK_HUMANPHLB3_HUMANBioGRID, IntAct27173435 unassigned1312 details
CLOCK_HUMANVPS53_HUMANBioGRID, IntAct27173435 unassigned1312 details
CLOCK_HUMANCCD93_HUMANBioGRID, IntAct27173435 unassigned1312 details
CLOCK_HUMANEIPR1_HUMANBioGRID, IntAct27173435 unassigned1312 details
CLOCK_HUMANGRAP1_HUMANBioGRID, IntAct27173435 unassigned1312 details
CLOCK_HUMANRABE1_HUMANBioGRID, IntAct27173435 unassigned1312 details
CLOCK_HUMANGIT2_HUMANBioGRID, IntAct27173435 unassigned1312 details
CLOCK_HUMANCAVN1_HUMANBioGRID, IntAct27173435 unassigned1312 details
CLOCK_HUMANPKN3_HUMANBioGRID, IntAct27173435 unassigned1312 details
CLOCK_HUMANVPS50_HUMANBioGRID, IntAct27173435 unassigned1312 details
CLOCK_HUMANRPR1A_HUMANBioGRID, IntAct27173435 unassigned1312 details
CLOCK_HUMANRABX5_HUMANBioGRID, IntAct27173435 unassigned1312 details
CLOCK_HUMANCBP_HUMANBioGRID26164627 details
CLOCK_HUMANCHIP_HUMANBioGRID32041778 details
CLOCK_HUMANPER3_HUMANHPRD14701732 details