Entity Details

Primary name FGF10_HUMAN
Entity type UniProt
Source Source Link

Details

AccessionO15520
EntryNameFGF10_HUMAN
FullNameFibroblast growth factor 10
TaxID9606
Evidenceevidence at protein level
Length208
SequenceStatuscomplete
DateCreated1999-07-15
DateModified2021-06-02

Ontological Relatives

GenesFGF10

GO terms

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GOName
GO:0000132 establishment of mitotic spindle orientation
GO:0000165 MAPK cascade
GO:0000187 obsolete activation of MAPK activity
GO:0001525 angiogenesis
GO:0001656 metanephros development
GO:0001759 organ induction
GO:0001823 mesonephros development
GO:0001934 positive regulation of protein phosphorylation
GO:0001974 blood vessel remodeling
GO:0003338 metanephros morphogenesis
GO:0005104 fibroblast growth factor receptor binding
GO:0005111 type 2 fibroblast growth factor receptor binding
GO:0005576 extracellular region
GO:0005615 extracellular space
GO:0005634 nucleus
GO:0005737 cytoplasm
GO:0005886 plasma membrane
GO:0007368 determination of left/right symmetry
GO:0007431 salivary gland development
GO:0008083 growth factor activity
GO:0008201 heparin binding
GO:0008284 positive regulation of cell population proliferation
GO:0008285 negative regulation of cell population proliferation
GO:0008543 fibroblast growth factor receptor signaling pathway
GO:0008589 regulation of smoothened signaling pathway
GO:0009880 embryonic pattern specification
GO:0009887 animal organ morphogenesis
GO:0009986 cell surface
GO:0010628 positive regulation of gene expression
GO:0010634 positive regulation of epithelial cell migration
GO:0010838 positive regulation of keratinocyte proliferation
GO:0021983 pituitary gland development
GO:0030154 cell differentiation
GO:0030334 regulation of cell migration
GO:0030538 embryonic genitalia morphogenesis
GO:0030878 thyroid gland development
GO:0030916 otic vesicle formation
GO:0030949 positive regulation of vascular endothelial growth factor receptor signaling pathway
GO:0031016 pancreas development
GO:0031069 hair follicle morphogenesis
GO:0031076 embryonic camera-type eye development
GO:0031532 actin cytoskeleton reorganization
GO:0032355 response to estradiol
GO:0032496 response to lipopolysaccharide
GO:0032781 positive regulation of ATPase activity
GO:0032808 lacrimal gland development
GO:0032925 regulation of activin receptor signaling pathway
GO:0034394 protein localization to cell surface
GO:0035019 somatic stem cell population maintenance
GO:0042056 chemoattractant activity
GO:0042060 wound healing
GO:0042246 tissue regeneration
GO:0042475 odontogenesis of dentin-containing tooth
GO:0042693 muscle cell fate commitment
GO:0043410 positive regulation of MAPK cascade
GO:0045596 negative regulation of cell differentiation
GO:0045739 positive regulation of DNA repair
GO:0045747 positive regulation of Notch signaling pathway
GO:0045944 positive regulation of transcription by RNA polymerase II
GO:0046579 positive regulation of Ras protein signal transduction
GO:0046877 regulation of saliva secretion
GO:0048146 positive regulation of fibroblast proliferation
GO:0048536 spleen development
GO:0048538 thymus development
GO:0048557 embryonic digestive tract morphogenesis
GO:0048754 branching morphogenesis of an epithelial tube
GO:0048807 female genitalia morphogenesis
GO:0048808 male genitalia morphogenesis
GO:0050671 positive regulation of lymphocyte proliferation
GO:0050673 epithelial cell proliferation
GO:0050674 urothelial cell proliferation
GO:0050677 positive regulation of urothelial cell proliferation
GO:0050679 positive regulation of epithelial cell proliferation
GO:0050731 positive regulation of peptidyl-tyrosine phosphorylation
GO:0050872 white fat cell differentiation
GO:0050918 positive chemotaxis
GO:0050930 induction of positive chemotaxis
GO:0051145 smooth muscle cell differentiation
GO:0051549 positive regulation of keratinocyte migration
GO:0051897 positive regulation of protein kinase B signaling
GO:0060019 radial glial cell differentiation
GO:0060054 positive regulation of epithelial cell proliferation involved in wound healing
GO:0060173 limb development
GO:0060174 limb bud formation
GO:0060428 lung epithelium development
GO:0060430 lung saccule development
GO:0060436 bronchiole morphogenesis
GO:0060447 bud outgrowth involved in lung branching
GO:0060449 bud elongation involved in lung branching
GO:0060496 mesenchymal-epithelial cell signaling involved in lung development
GO:0060510 type II pneumocyte differentiation
GO:0060513 prostatic bud formation
GO:0060595 fibroblast growth factor receptor signaling pathway involved in mammary gland specification
GO:0060615 mammary gland bud formation
GO:0060661 submandibular salivary gland formation
GO:0060664 epithelial cell proliferation involved in salivary gland morphogenesis
GO:0060665 regulation of branching involved in salivary gland morphogenesis by mesenchymal-epithelial signaling
GO:0060667 branch elongation involved in salivary gland morphogenesis
GO:0060879 semicircular canal fusion
GO:0060915 mesenchymal cell differentiation involved in lung development
GO:0061033 secretion by lung epithelial cell involved in lung growth
GO:0061115 lung proximal/distal axis specification
GO:0070075 tear secretion
GO:0070352 positive regulation of white fat cell proliferation
GO:0070371 ERK1 and ERK2 cascade
GO:0070374 positive regulation of ERK1 and ERK2 cascade
GO:0070384 Harderian gland development
GO:0071338 positive regulation of hair follicle cell proliferation
GO:0090263 positive regulation of canonical Wnt signaling pathway
GO:1900087 positive regulation of G1/S transition of mitotic cell cycle
GO:2001240 negative regulation of extrinsic apoptotic signaling pathway in absence of ligand

Subcellular Location

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Subcellular Location
Secreted

Domains

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DomainNameCategoryType
IPR002209 Fibroblast growth factor familyFamilyFamily
IPR008996 Cytokine IL1/FGFFamilyHomologous superfamily
IPR028252 Fibroblast growth factor 10FamilyFamily

Diseases

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Disease IDSourceNameDescription
180920 OMIMAplasia of lacrimal and salivary glands (ALSG)A rare condition characterized by dry conjunctival mucosae, irritable eyes, epiphora (constant tearing), and xerostomia (dryness of the mouth), which increases risk of dental erosion, dental caries, periodontal disease, and oral infections. ALSG has variable expressivity, and affected individuals may have aplasia or hypoplasia of the lacrimal, parotid, submandibular, and sublingual glands and absence of the lacrimal puncta. The disease is caused by variants affecting the gene represented in this entry.
149730 OMIMLacrimo-auriculo-dento-digital syndrome (LADDS)An autosomal dominant ectodermal dysplasia, a heterogeneous group of disorders due to abnormal development of two or more ectodermal structures. Lacrimo-auriculo-dento-digital syndrome is characterized by aplastic/hypoplastic lacrimal and salivary glands and ducts, cup-shaped ears, hearing loss, hypodontia and enamel hypoplasia, and distal limb segments anomalies. In addition to these cardinal features, facial dysmorphism, malformations of the kidney and respiratory system and abnormal genitalia have been reported. Craniosynostosis and severe syndactyly are not observed. The disease is caused by variants affecting the gene represented in this entry.